中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (41): 7779-7782.doi: 10.3969/j.issn.1673-8225.2011.41.045

• 组织构建循证医学 evidence-based medicine in tissue construction • 上一篇    下一篇

应用表皮生长因子治疗深Ⅱ度烧伤创面疗效的Meta分析

张宪发，梁自乾，宗守凯，赵学凯   

  1. 广西医科大学第一附属医院烧伤整形外科，广西壮族自治区南宁市  530021
  • 收稿日期:2011-04-11 修回日期:2011-05-28 出版日期:2011-10-08 发布日期:2011-10-08
  • 通讯作者: 梁自乾，教授，硕士生导师，广西医科大学第一附属医院烧伤整形外科，广西壮族自治区南宁市 530021 Liangzqian@yahoo.com.cn
  • 作者简介:张宪发★，男，1983年生，山东省汶上县人，汉族，广西医科大学2009级在读硕士，主要从事烧伤免疫及创面修复重建方面的研究。 zxianfa2003@ qq.com
  • 基金资助:

    广西研究生教育创新计划基金(2010105981002M187)。

Effectiveness of epidermal growth factor for treating deep second-degree burns in China: A Meta analysis

Zhang Xian-fa, Liang Zi-qian, Zong Shou-kai, Zhao Xue-kai   

  1. Department of Burns and Plastic Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning  530021, Guangxi Zhuang Autonomous Region, China
  • Received:2011-04-11 Revised:2011-05-28 Online:2011-10-08 Published:2011-10-08
  • Contact: Liang Zi-qian, Professor, Master's supervisor, Department of Burns and Plastic Surgery, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China Liangzqian@yahoo.com.cn
  • About author:Zhang Xian-fa★, Studying for master's degree, Department of Burns and Plastic Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China zxianfa2003@qq.com
  • Supported by:

    Graduate Education Innovation Fund of Guangxi Zhuang Autonomous Region, No.2010105981002M187*

PDF

473

被引次数

27

摘要：

背景：中国应用表皮生长因子治疗烧伤创面的临床研究较为广泛，但缺少大样本随机对照研究。
目的：对中国应用表皮生长因子治疗深Ⅱ度烧伤创面的疗效进行系统评价。
方法：应用计算机检索中国生物医学文献数据库(CBM，1979/2010)、万方数据库(1982/2011)、重庆维普中文科技期刊全文数据库(VIP，1989/2010)和中国期刊全文数据库(CNKI，1979/2010)，以“表皮生长因子”和“深Ⅱ度烧伤”为检索词，收集有关表皮生长因子治疗深Ⅱ度烧伤与不采用表皮生长因子治疗相比较的随机对照实验。评价纳入研究的方法学质量并进行资料提取后，采用RevMan 5.0软件进行Meta分析。
结果与结论：共纳入10个随机对照研究，包括536例深Ⅱ度烧伤患者。Meta分析结果显示：表皮生长因子治疗组创面愈合时间少于对照组(P < 0.01)；第2周和第3周创面愈合率表皮生长因子治疗组与对照组差异有显著性意义(P=0.000 2，P=0.01)；表皮生长因子治疗组瘢痕增生与对照组比较明显减少(P < 0.000 01)；而在减少烧伤创面疼痛方面两者差异无显著性意义(P=0.16)。表明应用表皮生长因子能明显促进烧伤创面的愈合和减少瘢痕增生的形成，但对缓解创面疼痛程度无明显优势。

关键词: 表皮生长因子, 深Ⅱ度烧伤, 随机对照试验, 系统评价, Meta分析

Abstract:

BACKGROUND: Epidermal growth factor (EGF) is widely used in the treatment of burn wound, and many articles have confirmed the effectiveness of EGF treatment. However, the deficient number of cases impacts the credibility of the articles.
OBJECTIVE: To assess the effectiveness of EGF for treating deep second-degree burns in China.
METHODS: We searched CMB (1979 to 2010), Wanfang Data (1982 to 2011), VIP (1989 to 2010) and CNKI (1979 to 2010). All searches were updated on January 15, 2007. Randomized controlled trials (RCTs) of EGF for deep second-degree burns were collected. The methodological quality of the included studies was evaluated, and data analyses were performed using the Cochrane Collaboration’s software RevMan 5.0.
RESUITS AND CONCLUSION: A total of 10 RCTs involving 536 deep second-degree burns patients were included. A descriptive analysis of the results was presented: The wound healing time in the EGF treatment group was less than the control group (P < 0.000 01). The wound healing rate between EGF treatment and control groups were significantly different by the second and third weeks, the results were (P=0.000 2, P=0.01). Compared with the control group, the scar proliferation index was significantly lower (P < 0.000 01). But in relieving the pain, there was no statistical difference between the two groups (P=0.16). Results showed that according to the domestic evidence, treatment for second-degree burns with EGF can improve the wound healing rate and lower the scar proliferation index. However, the effectiveness for relieving pains is not obvious.

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