中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (41): 7775-7778.doi: 10.3969/j.issn.1673-8225.2011.41.044

• 组织构建学术探讨 tissue construction academic discussion • 上一篇    下一篇

肌肉萎缩与过氧化体增殖活化受体γ辅助活化因子1α的关系

杨  殊，文  野   

  1. 国家体育总局湛江潜水运动学校，广东省湛江市，524005
  • 收稿日期:2011-06-09 修回日期:2011-09-19 出版日期:2011-10-08 发布日期:2011-10-08
  • 通讯作者: 文野，男，1957生，四川省成都市人，副研究员，国家体育总局湛江潜水运动学校，广东省湛江市，524005 wenyebox@hotmail.com
  • 作者简介:杨殊，女，1957年生，四川省宜宾市人，副研究员，主要从事运动训练学与运动人体科学研究。 zhangjiangys_2008@126.com

Relationship between muscular atrophy and peroxisome proliferator-activated receptor γ coactivator 1 alpha

Yang Shu, Wen Ye   

  1. Zhanjiang Diving Sport School of Chinese General Administration of Sport, Zhanjiang 524005, Guangdong Province, China
  • Received:2011-06-09 Revised:2011-09-19 Online:2011-10-08 Published:2011-10-08
  • Contact: Wen Ye, Associate researcher, Zhanjiang Diving Sport School of Chinese General Administration of Sport, Zhanjiang 524005, Guangdong Province, China wenyebox@hotmail.com
  • About author:Yang Shu, Associate researcher, Zhanjiang Diving Sport School of Chinese General Administration of Sport, Zhanjiang 524005, Guangdong Province, China zhangjiangys_2008@126.com

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摘要：

背景：过氧化体增殖活化受体γ辅助活化因子1α(peroxisome proliferator-activated receptor γ coactivator 1α，PGC-1α)能调节骨骼肌的功能，包括有：线粒体的生物发生、底物氧化和肌纤维类型等，最近还有研究发现PGC-1α能够预防肌肉的萎缩。
目的：总结并讨论PGC-1α与肌肉萎缩之间的关系。
方法：由第一作者用计算机检索中国期刊全文数据库(CNKI：2000/2010)和Medline数据库(2000/2010)，关键词分别为“肌肉萎缩，PGC-1α，运动”和“muscle atrophy，PGC-1α，exercise”。共检索到56篇文章，按纳入和排除标准对文献进行筛选，共纳入22篇文章。从PGC-1α与肌肉萎缩、运动与PGC-1α共2个方面进行总结。
结果与结论：PGC-1α表达增强能提高线粒体功能、人体的运动能力、降低氧化应激和抑制肌肉萎缩特异性基因的表达。说明运动可通过调节PGC-1α的表达来干预肌肉萎缩。

关键词: 过氧化体增殖活化受体&gamma, 辅助活化因子1&alpha, 肌肉萎缩, 运动, 氧化应激, 组织工程

Abstract:

BACKGROUND: Peroxisome proliferator-activated receptor γ coactivator 1 alpha (PGC-1α) can regulate numerous skeletal muscle functions including mitochondrial biogenesis, substrate oxidation, and muscle fibre type. Recently, PGC-1α has been found to prevent against muscular atrophy.
OBJECTIVE: To summarize and discuss the relationship between PGC-1α and muscular atrophy.
METHODS: A computer-based online retrieval of CNKI and Medline databases was performed by the first author to search  papers published between 2000 and 2010 using the key words “muscle atrophy, PGC-1α, exercise” in Chinese or English. A total of 56 papers were retrieved. According to inclusion and exclusion criteria, 22 papers were included in the final analysis. These papers were summarized from PGC-1α and muscular atrophy, and exercise and PGC-1α.
RESULTS AND CONCLUSION: Enhanced PGC-1α expression can enhance mitochondrial function and human sport ability, reduce oxidative stress and inhibit the expression of muscular atrophy specific gene. Therefore, exercise may inhibit muscular atrophy by regulating PGC-1α expression.

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