中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (40): 7589-7592.doi: 10.3969/j.issn.1673-8225.2011.40.042

• 干细胞临床实践 clinical practice of stem cells • 上一篇    下一篇

自体骨髓间充质干细胞回输对脑性瘫痪儿童运动功能发育的影响

陈文明1，胡运新1，尹靖宇2，卢建军1，王  建2，邹清雁3   

  1. 广东三九脑科医院，1神经内科，2脑瘫科，3神经医学实验室，广东省广州市  510510
  • 收稿日期:2011-04-08 修回日期:2011-06-30 出版日期:2011-10-01 发布日期:2011-10-01
  • 作者简介:陈文明★，男，1963年生，浙江省义乌市人，汉族，1992年解放军第一军医大学(现南方医科大学)毕业，硕士，副主任医师，主要从事干细胞治疗中枢神经系统疾病、中枢性眩晕的诊断、药物及康复治疗等方面的研究。 wenming6311@tom.com

Effect of autologous bone marrow mesenchymal stem cell transplantation on motor development of cerebral palsy children

Chen Wen-ming1, Hu Yun-xin1, Yin Jing-yu2, Lu Jian-jun1, Wang Jian2, Zou Qing-yan3   

  1. 1Department of Neurology, 2Department of Cerebral Palsy, 3Laboratory of Neurology, Guangdong 999 Brain Hospital, Guangzhou  510510, Guangdong Province, China
  • Received:2011-04-08 Revised:2011-06-30 Online:2011-10-01 Published:2011-10-01
  • About author:Chen Wen-ming★, Master, Associate chief physician, Department of Neurology, Guangdong 999 Brain Hospital, Guangzhou 510510, Guangdong Province, China wenming6311@tom.com

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419

被引次数

5

摘要：

背景：自体骨髓干细胞对神经系统疾病具有一定的治疗作用，但对脑瘫治疗缺乏系统有对照的临床研究。
目的：分析自体骨髓间充质干细胞移植对脑性瘫痪儿童运动功能发育的影响。
方法：将34例脑性瘫痪者按其家长是否同意使用自体骨髓干细胞移植治疗分为治疗组和对照组，治疗组采取自体骨髓间充质干细胞移植结合康复训练，对照组只采用康复训练，分别在治疗前和治疗后3个月做粗大运动功能测试量表(GMFM)评估并进行对比。
结果与结论：与治疗前比较，2组治疗后3个月GMFM评分均增高，而GMFM评分增加量均降低，差异均有显著性意义 (P < 0.05)。治疗组GMFM评分增加量高于对照组(P < 0.05)。 提示自体骨髓间充质干细胞移植治疗脑性瘫痪是有效的，对促进脑性瘫痪患儿运动功能发育有积极作用。

关键词: 脑性瘫痪, 骨髓间充质干细胞, 移植, GMFM, 运动功能发育

Abstract:

BACKGROUND: Previous clinic studies demonstrated bone marrow mesenchymal stem cells (BMSCs) could play a role in treating nervous system diseases; however, the effect of BMSCs on treating cerebral palsy has been less reported.
OBJECTIVE: To analyze the effect of autologous BMSCs transplantation on the promotion of motor development in cerebral palsy children. 
METHODS: A total of 34 cerebral palsy children were divided into control and treatment groups according to the wishes of their parents. Treatment group received autologous BMSCs transplantation plus rehabilitation training, while the control group only underwent rehabilitation training. The modified Gross Motor Function Classification Measure (GMFM) was performed before treatment and after 3 months treatment.
RESULTS AND CONCLUSION: The GMFM scores increased significantly in the two groups after 3 months treatment (P < 0.01). The increment of GMFM scores in the treatment group was more than that in the control group after 3 months treatment. Autologous BMSCs transplantation is effective, and may play an active role in the motor development in cerebral palsy children.

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