中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (40): 7593-7596.doi: 10.3969/j.issn.1673-8225.2011.40.043

• 干细胞临床实践 clinical practice of stem cells • 上一篇    下一篇

ABO血型不合外周血造血干细胞移植10例

金哈斯1，鲁燕侠1，陶格斯花2，龚丽萍3，母立新4   

  1. 1武警总医院血液科，北京市100039
    2内蒙古乌拉特前旗中蒙医院，内蒙古自治区巴彦淖尔市  014400
    3首都医科大学病理系，北京市  100612
    4首都机场医院外科，北京市100090
  • 收稿日期:2011-03-10 修回日期:2011-04-20 出版日期:2011-10-01 发布日期:2011-10-01
  • 通讯作者: 母立新，硕士，主治医师，首都机场医院外科，北京市100090
  • 作者简介:金哈斯☆，女，1963年生，内蒙古自治区人，蒙古族，2000年解放军军医进修学院毕业，博士，副主任医师，主要从事淋巴瘤，白血病方面的研究。 wujingjhs@yahoo.com.cn

ABO-incompatible peripheral hematopoietic stem cell transplantation in 10 cases

Jin Ha-si1, Lu Yan-xia1, Tao Ge Si Hua2, Gong Li-ping3, Mu Li-xin4   

  1. 1Department of Hematology, General Hospital of Armed Police Forces, Beijing  100039, China
    2Zhong Meng Hospital of Wulate Qian Qi, Bayan Nur  014400, Inner Mongolia Autonomous Region, China
    3Department of Pathology, Capital Mediacl University, Beijing  100612, China
    4Capital Airport Hospital, Beijing  100090, China
  • Received:2011-03-10 Revised:2011-04-20 Online:2011-10-01 Published:2011-10-01
  • Contact: Mu Li-xin, Master, Attending physician, Capital Airport Hospital, Beijing 100090, China
  • About author:Jin Ha-si☆, Doctor, Associate chief physician, Department of Hematology, General Hospital of Armed Police Forces, Beijing 100039, China wujingjhs@yahoo.com.cn

PDF

520

被引次数

9

摘要：

背景：ABO血型不合供受者之间进行外周血造血干细胞移植，面临受者血型的转变、移植后输血的选择等问题。
目的：观察ABO血型不合外周血造血干细胞移植治疗血液病的临床疗效和近远期并发症。
方法：回顾性分析了2005/2008武警总医院收治的10例ABO血型不合异基因外周血同胞供者造血干细胞移植患者的资料。总结植入效果，血型转变，移植物抗宿主病以及不良反应。
结果与结论：9例患者恢复造血功能，血型转变为完全供者型，1例患者白细胞血小板恢复，但红细胞植入延迟。所有患者在输注移植物时未出现短暂的血红蛋白尿，无严重急性溶血和迟发型溶血的发生，1例出现严重的移植物抗宿主病。可见ABO血型不合外周血造血干细胞移植对移植疗效无明显影响，红细胞植入延迟的预防和处理十分重要。

关键词: 造血干细胞, 细胞移植, ABO血型系统, 血型不合, 溶血

Abstract:

BACKGROUND: During ABO-incompatible peripheral hematopoietic stem cell transplantation, it is very important to observe the change of blood type of patients and to select correct blood type in transfusion.
OBJECTIVE: To observe the clinical effect and short-term and long-term complications in ABO-incompatible allogeneic peripheral hematopoietic stem cell transplantation.
METHODS: Ten patients after ABO-incompatible peripheral hematopoietic stem cell transplantation were enrolled between 2005 and 2008. Transplantation effect, blood changes, graft-versus-host disease and adverse reactions were analyzed after the trasplantation.
RESULTS AND CONCLUSION: Nine patients had hematological recovered after transplantation, and their blood types were changed to donors’ blood types. One patient had delayed red blood cell engraftment and developed pure red cell aplasia. One patient developed severe graft-versus-host disease. Transient hemoglobinuria, severe acute hemolysis and non-delayed hemolysis did not occur. ABO-incompatible peripheral hematopoietic stem cell transplantation has no apparent impact on transplant outcomes. Strategies to prevent and treat pure red cell aplasia are very important.

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