中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (1): 126-129.doi: 10.3969/j.issn.1673-8225.2011. 01.028

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

疾病特异诱导多能干细胞距离神经退行性疾病的临床治疗还有多远

罗  虎1，刘渔凯1，李泽桂2   

  1. 解放军第三军医大学，1学员旅17队，2药学院生药学教研室，重庆市  400038
  • 收稿日期:2010-09-21 修回日期:2010-10-26 出版日期:2011-01-01 发布日期:2011-01-01
  • 通讯作者: 李泽桂，博士，教授，解放军第三军医大学药学院生药学教研室，重庆市400038 lizegui@tmmu.edu.cn
  • 作者简介:罗虎，男，四川省内江市人，汉族，解放军第三军医大学临床医学八年制在读。 luohucy@163.com
  • 基金资助:

    第三军医大学创新基金资助项目(2007XG42)。

How long will the disease-specific induced pluripotent stem cells be applied in the clinical treatment of neurodegenerative diseases  

Luo Hu1, Liu Yu-kai1, Li Ze-gui2   

  1. 1The Seventeen Student Group, Third Military Medical University of Chinese PLA, Chongqing  400038, China
    2Department of Pharmacognosy, Pharmacy College, Third Military Medical University of Chinese PLA, Chongqing  400038, China
  • Received:2010-09-21 Revised:2010-10-26 Online:2011-01-01 Published:2011-01-01
  • Contact: Li Ze-gui, Doctor, Professor, Department of Pharmacognosy, Pharmacy College, Third Military Medical University of Chinese PLA, Chongqing 400038, China lizegui@tmmu.edu.cn
  • About author:Luo Hu, The Seventeen Student Group, Third Military Medical University of Chinese PLA, Chongqing 400038, China luohucy@163.com
  • Supported by:

    the Innovation Foundation of Third Military Medical University of Chinese PLA, No. 2007XG42

PDF

488

被引次数

5

摘要：

背景：各种神经退行性疾病传统的内外科治疗只能缓解症状而不能阻止疾病的进一步发展，细胞替代治疗近年进展迅速，但是干细胞存在的伦理问题及免疫排斥等问题不容忽视，而诱导多能干细胞的产生为这些问题提供了新的解决途径。
目的：综述神经退行性疾病的治疗现状以及诱导多能干细胞作为新的细胞来源治疗神经退行性疾病的可能性。
方法：应用计算机检索1995/2010 PubMed数据库(http://www.ncbi.nlm.nih.gov/PubMed)及万方数据库(http://www.wanfangdata.com.cn)，英文检索词为“induced pluripotent stem cell，PD，ALS，SMA, degenerative disease”，中文检索词为“干细胞，帕金森病”。初检得到文献374篇，根据纳入标准选择29篇文章进行综述。
结果与结论：疾病特异诱导多潜能干细胞可保持疾病特异的基因型，有利于疾病分子机制的进一步阐明，且其拥有与胚胎干细胞类似的多向分化能力；在体外动物模型中可分化为多巴胺能神经元，缓解帕金森病的临床症状，在神经退行性疾病的临床治疗方面具有广泛的应用前景。

关键词: 诱导多能干细胞, 帕金森病, 脊髓侧索硬化, 脊髓性肌萎缩, 神经退行性疾病

Abstract:

BACKGROUND: Both the medical treatments and the surgery can only relieve the symptoms but not prevent the progress of neurodegenerative diseases. Cell replacement therapy proceeds fast but its ethical problem and immune rejection also should be in consideration. However, the production of induced pluripotent stem cells provides us a new way to resolve these problems.
OBJECTIVE: To review the basic situations and current treatment of neurodegenerative diseases and the possibility of the induced pluripotent stem (iPS) cells be used in regenerative medicine as a new cell resource.
METHODS: The PubMed database (http://www.ncbi.nlm.nih.gov/PubMed) and Wanfang database (http://www.wanfangdata.com.cn) were retrieved for articles published from 1995 to 2010 by computer. The English key words were “induced pluripotent stem cell, PD, ALS, SMA, degenerative disease”. The Chinese key words were “stem cells, Parkinson’s disease”. Totally 374 papers were primarily gotten. Finally, 29 papers were selected according to the inclusion criteria.
RERULTS AND CONCLUSION: Patient-specific iPS cells can obtain the same genotype which is beneficial to the elucidation of the molecular mechanism of these diseases. These cells also posses the similar multi-directional differentiation ability as embryonic stem cells, which could be induced to dopamine neurons and relieve the clinical symptoms of Parkinson’s disease in animal model in vitro. The iPS cells have broad prospect in the treatment of neurodegenerative diseases.

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