中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (51): 9667-9670.doi: 10.3969/j.issn.1673-8225.2010.51.039

• 生物材料学术探讨 biomaterial academic discussion • 上一篇    下一篇

组织工程软骨支架材料研究热点与软骨运动损伤的修复

马志勇   

  1. 唐山师范学院体育系，河北省唐山市063000
  • 出版日期:2010-12-17 发布日期:2010-12-17
  • 作者简介:马志勇，男，1977年生，汉族，河北省秦皇岛市人，讲师，2001年河北师范大学毕业，主要从事运动训练与康复保健学方面的研究。 sqh@hpu.edu.cn

Hot spots for tissue engineered cartilage scaffold and repair of sports-induced cartilage damage

Ma Zhi-yong   

  1. Department of Physical Education, Tangshan Teachers College, Tangshan   063000, Hebei Province, China
  • Online:2010-12-17 Published:2010-12-17
  • About author:Ma Zhi-yong, Lecturer, Department of Physical Education, Tangshan Teachers College, Tangshan 063000, Hebei Province, China sqh@hpu.edu.cn

PDF

468

被引次数

6

摘要：

背景：从大量研究资料来看，运用组织工程支架材料修复软骨损伤日趋成熟与多样，构建生物特性与正常关节软骨相似的组织工程软骨已经成为目前研究的热点。
目的：对软骨生理特点及损伤因素进行探讨，对目前在关节软骨修复中的生物支架材料进行分类和归纳。
方法：作者应用计算机检索PubMed数据库(http://www.ncbi.nlm.nih.gov/PubMed)及CNKI数据库(www.cnki.net/ index.htm)，在标题和摘要中以“Cartilage，Damage，Biological Materials，Suppor”或“软骨，损伤，生物材料，支架”为检索词进行检索。选择文章内容与软骨支架材料治疗手段、材料学特点、生物相容性及其应用效果相关，同一领域文献则选择近期发表或发表在权威杂志文章。共纳入28篇文献。
结果：人体软骨组织损伤后自我康复较难，植入组织工程支架材料成为软骨组织修复的重要手段。软骨组织工程支架材料的选择与研制经历了天然材料、合成材料等由单一材料向复合材料研制的快速发展时期，可注射材料、基因技术和纳米材料以及改性修饰材料技术的运用，正成为目前研究的热点和发展趋势。

关键词: 软骨, 损伤, 生物材料, 支架, 进展　

Abstract:

BACKGROUND: The use of tissue engineered scaffold material is mature and diversifying for repairing cartilage damage, constructing tissue-engineered cartilage with similar biological properties to normal articular cartilage has become a research hotspot.
OBJECTIVE: To investigate the physiological characteristics and damage factor of the cartilage, to classify and summarize the current scaffold biomaterials in articular cartilage repair.
METHODS: A computer-based online search of PubMed database (http://www.ncbi.nlm.nih.gov/PubMed) and CNKI database (www.cnki.net/index.htm) was performed, with the key words of “Cartilage, Damage, Biological Materials, Scaffold” in English and in Chinese to search the title and summary. Articles on treatment approach, materials science characteristics, biocompatibility and its application effect of cartilage scaffolds were selected, those recently published or published in the authority journals were preferred. A total of 28 articles were included.
RESULTS AND CONCLUSION: Human cartilage tissue is difficult to self-rehabilitate after injury, the implanted tissue engineered scaffold material serves as an important means of cartilage tissue repair. Choice for cartilage tissue engineering scaffolds has developed through natural materials, synthetic materials, and other single materials to composite material, the injectable materials, genetic technology and nano-materials, as well as modified materials technology are becoming currently a hot research and development trend.

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