中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (4): 689-692.doi: 10.3969/j.issn.1673-8225.2010.04.028

• 骨与关节综述 bone and joint review • 上一篇    下一篇

脉冲电磁场影响骨折愈合的研究进展

刘纪涛，陶  军   

  1. 南昌大学第三附属医院，江西省南昌市  330008
  • 出版日期:2010-01-22 发布日期:2010-01-22
  • 通讯作者: 陶 军，南昌大学第三附属医院骨一科，江西省南昌市 330008 taojun125@ sohu.com
  • 作者简介:刘纪涛★，男，1980年生，陕西省汉中市人，南昌大学医学院在读硕士，医师，主要从事骨关节疾病方面的研究。 bluceliu123@163.com
  • 基金资助:

    2009~2010年度江西省卫生厅科技计划项目(20093164)。

Research development of pulsed electromagnetic fields in bone fracture healing

Liu Ji-tao, Tao Jun   

  1. First Department of Orthopaedics, Third Affiliated Hospital of Nanchang University, Nanchang   330008, Jiangxi Province, China
  • Online:2010-01-22 Published:2010-01-22
  • Contact: Tao Jun, First Department of Orthopaedics, Third Affiliated Hospital of Nanchang University, Nanchang 330008, Jiangxi Province, China taojun125@sohu.com
  • About author:Liu Ji-tao★, Studying for master’s degree, Physician, First Department of Orthopaedics, Third Affiliated Hospital of Nanchang University, Nanchang 330008, Jiangxi Province, China bluceliu123@163.com
  • Supported by:

    Scientific and Technological Project of Jiangxi Provincial Public Health Department2009-2010, No.20093164*

PDF

618

被引次数

29

摘要：

背景：随着人们寻求促进骨折愈合方法的同时，脉冲电磁场以其无创伤、无感染、治疗方便、副作用小等优点日益受到人们的关注与重视。
目的：通过查阅大量相关资料并进行分析总结，从作用机制、动物实验和临床应用入手，对脉冲电磁场影响骨折愈合的研究现状进行综述，以期为促进骨折愈合提供新的思路和理论依据。
方法：由第一作者检索Pubmed数据库(http://www.ncbi.nlm.gov/Pubmed) 1989/2009及维普数据库(www.cqvip.com) 1981/2009的相关文章。英文检索词为“PEMF，fracture”，中文检索词为“脉冲电磁场，骨折”。纳入与脉冲电磁场或电磁场治疗骨折密切相关，同一领域选择近期发表或在权威杂志上发表的文章；排除重复性文献。文献类型包括综述、动物试验和临床试验等。计算机初检得到62篇文献，英文32篇，中文30篇。阅读标题和摘要进行初筛，排除因研究目的与此文无关的9篇，内容重复性的研究6篇，综述、述评类7篇，保留40篇文献做进一步分析，包括16篇中文，24篇英文文献；其中动物实验和体内、体外、细胞学实验31篇，临床研究9篇。
结果与结论：脉冲电磁场治疗骨折具有安全、环保、无创性、无感染、操作简便、适用范围广和并发症少等优点，动物实验和临床应用等证实脉冲电磁场是一种有效的促进骨折愈合的方法，目前公认的是要应用低频率、低强度。脉冲电磁场治疗骨折，不仅涉及物理学，而且涉及医学等多个学科，由于对电磁方面研究进展，以及机体的复杂性及伦理方面问题，其作用机制以及脉冲电磁场参数值及各参数间该如何组合还有待进一步探索。

关键词: 脉冲电磁场, 骨折愈合, 作用机制, 临床应用, 综述文献

Abstract:

BACKGROUND: Pulsed electromagnetic field attracts much attention due to its less trauma, infection, side effect, and simple application to promote bone fracture healing.
OBJECTIVE: To review the effect of pulsed electromagnetic fields on bone fracture healing by mechanism, animal experiments, and clinical application so as to provide theoretical evidences for promoting bone fracture healing.
METHODS: This study was retrieved by the first author with the key words of “PEMF and fracture” in both English (1989-2009) and Chinese (1981-2009) from Pubmed database (http://www.ncbi.nlm.gov/Pubmed) and Vip database (www.cqvip.com). Articles which were related with the effect of pulsed electromagnetic fields or electromagnetic field on bone fracture healing were included. The duplicated articles were excluded. The retrieval articles included reviews, animal experiments, and clinical experiments. Among 62 articles, 32 were in English and 30 in Chinese. Following the primary retrieval, 9 articles were excluded due to unrelated researching aim, 6 due to duplication, and 7 due to reviews. A total of 40 articles, 16 in Chinese and 24 in English, were included in the final analysis, including animal and cytological experiments (n=31), and clinical studies (n=9). 
RESULTS AND CONCLUSION: Pulsed electromagnetic field characterized by security, environmental protection, non-trauma, non-infection, sample processing, wide applicability, and less complications for treating bone fracture healing. Clinical experiments and clinical application have proved that pulsed electromagnetic field was an effective method to promote bone fracture healing, characterizing by low frequency and intensity. The mechanism of pulsed electromagnetic field for promoting bone fracture healing involved in physics and medicine. With the research of electromagnetism, organic complexity, and ethics, the parameters of pulsed electromagnetic field need to be further studied.

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