[1] SILVERWOOD V, BLAGOJEVIC-BUCKNALL M, JINKS C, et al.Current evidence on risk factors for knee osteoarthritis in older adults: a systematic review and meta-analysis. Osteoarthritis Cartilage.2015;23(4):507-515.
[2] 贺宪,孔畅,曾巧,等.淫羊藿苷对骨性关节炎家兔BMSCs增殖及软骨定向分化影响的实验研究[J].湖南中医杂志,2017, 33(3):140-143.
[3] JIAO F, TANG W, HUANG H, et al. Icariin Promotes the Migration of BMSCs In Vitro and In Vivo via the MAPK Signaling Pathway.tem Cells Int.2018;2018:2562105.
[4] WANG Z, LI K, SUN H, et al. Icariin promotes stable chondrogenic differentiation of bone marrow mesenchymal stem cells in self assembling peptide nanofiber hydrogel scaffolds. Mol Med Rep.2018;17(6):8237-8243.
[5] 黄荷,曾意荣,简林养.淫羊藿甙诱导人骨髓间充质干细胞向软骨细胞分化实验研究[J].新中医,2016,48(1):210-212.
[6] SCHMINKE B, FRESE J, BODE C, et al.Laminins and Nidogens in the Pericellular Matrix of Chondrocytes: Their Role in Osteoarthritis and Chondrogenic Differentiation. Am J Pathol. 2016;186(2):410-418.
[7] 赵晓燕.淫羊藿苷对人骨关节炎软骨细胞增殖凋亡的影响[J].海南医学,2018,29(1):10-13.
[8] 桑敬伟,韦中阳,李国有,等.中药淫羊藿甙干预TDP-43介导的骨关节炎软骨细胞病变的分子机制[J].中华实验外科杂志, 2018,35(10):1986.
[9] 张君涛,王平,穆刚,等.淫羊藿苷含药血清对兔软骨细胞增殖及糖胺聚糖分泌的影响[J].中华中医药杂志,2018,33(4): 1601-1604.
[10] 李红明,高原,胡小雄.淫羊藿苷促进骨膜细胞增殖及其机制[J].中国组织工程研究,2018,22(4):505-509.
[11] 路丰军.生物3D打印制备SA/Ge凝胶支架探究淫羊藿苷对软骨细胞增殖、分泌的影响[D].泉州:华侨大学,2017.
[12] 何李乐,王万春.淫羊藿素对大鼠软骨细胞作用的实验研究[J].中南大学学报(医学版),2015,40(5): 517-521.
[13] 王鹏珍,万超.淫羊藿苷促进软骨细胞体外3-D培养下生成软骨[J].中国老年学杂志,2015,35(10): 2597-2600.
[14] BAHRAMI M, VALIANI A, AMIRPOUR N, et al. Cartilage Tissue Engineering Via Icariin and Adipose-derived Stem Cells in Fibrin Scaffold.Adv Biomed Res.2018;7:36.
[15] 蔡希.丁二酸淫羊藿苷单酯的制备及其在骨和软骨组织工程中的应用[D].成都:成都理工大学,2017.
[16] 李伟,王战伟,伍晓,等.载淫羊藿素多孔PLGA/TCP联合微骨折术修复兔膝关节软骨缺损的初步观察[J].中国当代医药,2016, 23(22):7-10.
[17] 刘益杰,陈世宣,赵仙丽,等.淫羊藿苷对白介素-1β诱导软骨细胞退变的保护作用[J].同济大学学报(医学版),2018.39(2): 56-60.
[18] ZHAO CF, LI ZH, LI SJ, et al. PLGA scaffold carrying icariin to inhibit the progression of osteoarthritis in rabbits. R Soc Open Sci.2019;6(4):181877.
[19] 张君涛,张栋林,吴超超,等.淫羊藿苷与透明质酸结合物的制备及其对膝关节软骨缺损兔软骨组织的保护作用[J].山东医药, 2018,58(16): 30-33.
[20] NIEBLER S, SCHUBERT T, HUNZIKER EB, et al.Activating enhancer binding protein 2 epsilon (AP-2ε)-deficient mice exhibit increased matrix metalloproteinase 13 expression and progressive osteoarthritis development.Arthritis Res Ther.2015;17: 119.
[21] LI W, WU M, JIANG S, et al. Expression of ADAMTs-5 and TIMP-3 in the condylar cartilage of rats induced by experimentally created osteoarthritis.Arch Oral Biol.2014; 59(5):524-529.
[22] 李安琪,刘益杰,冯伟,等.淫羊藿苷对IL-1β诱导的炎症性软骨细胞表型与代谢的影响[J].上海中医药杂志,2018,52(2): 99-103.
[23] DY P, WANG W, BHATTARAM P, et al. Sox9 directs hypertrophic maturation and blocks osteoblast differentiation of growth plate chondrocytes.Dev Cell.2012; 22(3): 597-609.
[24] LUO Y, ZHANG Y, HUANG Y.Icariin Reduces Cartilage Degeneration in a Mouse Model of Osteoarthritis and is Associated with the Changes in Expression of Indian Hedgehog and Parathyroid Hormone-Related Protein.Med Sci Monit.2018;24:6695-6706.
[25] ZHANG J, ZHANG D, WU C, et al.Icariin-conditioned serum engineered with hyaluronic acid promote repair of articular cartilage defects in rabbit knees.BMC Complement Altern Med. 2019;19(1):155.
[26] ZENG L, RONG XF, LI RH, et al.Icariin inhibits MMP1, MMP3 and MMP13 expression through MAPK pathways in IL1betastimulated SW1353 chondrosarcoma cells.Mol Med Rep. 2017;15(5):2853-2858.
[27] 张景,张水花,沈思,等.T1ρ成像技术监测淫羊藿治疗早期兔膝软骨退变[J].实用放射学杂志,2016,32(10):1609-1613.
[28] CASTAÑEDA S, ROMAN-BLAS JA, LARGO R, et al. Subchondral bone as a key target for osteoarthritis treatment.Biochem Pharmacol.2012;83(3): 315-323.
[29] FINDLAY DM, ATKINS GJ.Osteoblast-chondrocyte interactions in osteoarthritis.Curr Osteoporos Rep.2014; 12(1): 127-134.
[30] 彭晨健,杜斌,孙光权,等.3D打印β-磷酸三钙支架复合淫羊藿苷微粒修复兔股骨头坏死[J].中国组织工程研究,2019,23(14): 2162-2168.
[31] 邓君,邱波.淫羊藿苷对骨质疏松性老年骨折模型愈合过程的影响[J].中国老年学杂志,2018,38(5):1187-1190.
[32] WEI CC, PING DQ, YOU FT, et al. Icariin Prevents Cartilage and Bone Degradation in Experimental Models of Arthritis.Mediators Inflamm.2016;2016:9529630.
[33] 许静,张晶晶,郭非非,等.淫羊藿黄酮类主要成分促进骨髓间充质干细胞向成骨细胞增殖分化作用及机制的影响[J].中国实验方剂学杂志,2017,23(14):113-120.
[34] 谢利娜,刘艳辉,景向东.淫羊藿苷促进体外培养成骨细胞增殖动态观察[J].辽宁中医药大学学报, 2018,20(7): 54-57.
[35] 贾英民,李瑞玉,武密山,等.补肾中药成分配伍对成骨细胞成骨活性及Smad4 mRNA表达的影响[J].中国组织工程研究,2015, 19(33):5289-5294.
[36] 李磊,郑怀亮,寇玉,等.淫羊藿苷诱导骨髓间充质干细胞成骨细胞分化的研究[J].中华中医药杂志, 2018,33(6): 2599-2601.
[37] 谢利娜,刘艳辉,赵波,等.淫羊藿苷与BMP-2对体外培养成骨细胞增殖的影响[J].北京口腔医学,2018, 26(6): 319-322.
[38] 涂艳,熊莉娜,柳湘洁,等.淫羊藿苷对成骨细胞成骨分化的影响及Wnt/-catenin信号系统的关系研究[J].中国中医急症,2017, 26(3):448-450+466.
[39] 宋利格,张秀珍,张克勤,等.雌激素受体介导的ERK、JNK途径在淫羊藿促成骨细胞增殖分化过程中的分子机制[J].中华内分泌代谢杂志,2015,31(2):148-154.
[40] YANG J, LIU Y, HE L, et al.Icariin conjugated hyaluronic acid/collagen hydrogel for osteochondral interface restoration.Acta Biomater.2018;74:156-167.
[41] LIU N, ZHANG T, CAO BR, et al.Icariin possesses chondroprotective efficacy in a rat model of dexamethasone-induced cartilage injury through the activation of miR-206 targeting of cathepsin K.Int J Mol Med.2018;41(2):1039-1047.
[42] WANG P, ZHANG F, HE Q, et al. Flavonoid Compound Icariin Activates Hypoxia Inducible Factor-1α in Chondrocytes and Promotes Articular Cartilage Repair.PLoS One.2016;11(2):e0148372.
[43] 王磊,董红,孔继昌,等.膝骨关节炎患者血清和关节液中MMP-13和TNF-α水平的变化意义[J].中国医药导报,2017, 14(15):98-101.
[44] RAMONDA R, OLIVIERO F, SCANU A, et al. FRI0319 Lev-els of IL-1βand MMP-3 are increased in the synovial fluid fromknee osteoarthritis (OA) in patients with concomitant erosivehand OA. Ann Rheum Dis.2013;71 (Suppl 3):421-422.
[45] FIORENTINO DF, ZLOTNIK A, MOSMANN TR, et al. Pil-lars article:IL-10 inhibits cytokine production by activated mac-rophages.J Immunol.2016;197(5): 1539-1546.
[46] MI B, WANG J, LIU Y, et al. Icariin Activates Autophagy via Down-Regulation of the NF-κB Signaling-Mediated Apoptosis in Chondrocytes.Front Pharmacol.2018;9:605.
[47] LIU Y, MI B, LV H, et al.Shared KEGG pathways of icariin-targeted genes and osteoarthritis.J Cell Biochem. 2018 Dec 3.
[48] 秦丰伟,黄荷,焦锋,等.淫羊藿苷和骨髓间充质干细胞共育液对兔骨关节炎模型关节液中IL-1、TNF-α、IL-10、MMP-3表达的影响[J].实用医学杂志,2018,34(17):2876-2879.
[49] 吴迎春,吕刚,依力潘•凯赛尔,等.淫羊藿总黄酮联合硫酸氨基葡萄糖对膝骨关节炎疗效临床研究[J].中国骨质疏松杂志, 2017,23(9):1195-1198.
[50] 高堪达,王漱阳,王秋根.淫羊藿苷治疗小鼠骨关节炎后血清学及组织学改变的实验研究[J].中国修复重建外科杂志,2017, 31(8):963-969.
[51] 潘连红.淫羊藿苷对骨关节炎滑膜细胞中MMP14表达和细胞增殖调控的研究[D].重庆:重庆大学,2016.
[52] HUANG H, ZHANG ZF, QIN FW,et al.Icariin inhibits chondrocyte apoptosis and angiogenesis by regulating the TDP-43 signaling pathway.Mol Genet Genomic Med.2019; 7(4):e00586.
[53] PAN L, ZHANG Y, CHEN N, et al.Icariin Regulates Cellular Functions and Gene Expression of Osteoarthritis Patient-Derived Human Fibroblast-Like Synoviocytes.Int J Mol Sci. 2017;18(12). pii: E2656.
[54] XING D, XU Y, LIU Q, et al.Osteoarthritis and all-cause mortality in worldwide populations: grading the evidence from a meta-analysis.Sci Rep.2016;6:24393.
|