中国组织工程研究

中国组织工程研究 ›› 2017, Vol. 21 ›› Issue (11): 1783-1789.doi: 10.3969/j.issn.2095-4344.2017.11.025

• 骨与关节综述 bone and joint review • 上一篇    下一篇

强直性脊柱炎动物模型归类及其机制研究与进展

谭 希1，徐永跃1，邱冬妮1，黄闰月1，2，何羿婷1，3   

  1. 1广州中医药大学第二临床医学院，广东省广州市 510405；2广东省中医药科学院，广东省广州市  510006；3广东省中医院新药开发办，广东省广州市   510120
  • 修回日期:2016-12-06 出版日期:2017-04-18 发布日期:2017-05-06
  • 通讯作者: 何羿婷，博士，教授，广州中医药大学第二临床医学院，广东省广州市 510405
  • 作者简介:谭希，女，1990年生，江西省萍乡市人，汉族，广州中医药大学在读硕士，主要从事中医药治疗风湿性疾病的研究。
  • 基金资助:

    国家自然科学基金资助项目(81273736，81673898)

Research progress of classification and pathogenesis in ankylosing spondylitis animal models

Tan Xi1, Xu Yong-yue1, Qiu Dong-ni1, Huang Run-yue1, 2, He Yi-ting1, 3   

  1. 1Second Institute of Clinical Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China; 2Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou 510006, Guangdong Province, China; 3New Drug Development Center of Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou 510120, Guangdong Province, China
  • Revised:2016-12-06 Online:2017-04-18 Published:2017-05-06
  • Contact: He Yi-ting, M.D., Professor, Second Institute of Clinical Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China; New Drug Development Center of Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou 510120, Guangdong Province, China
  • About author:Tan Xi, Studying for master’s degree, Second Institute of Clinical Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China
  • Supported by:

    the National Natural Science Foundation of China, No. 81273736, 81673898

PDF

316

被引次数

6

摘要：

文章快速阅读：

 
 

 

文题释义：
人类白细胞抗原B27：人类白细胞抗原B27与强直性脊柱炎的发病密切相关，并有明显家族发病倾向。国内强直性脊柱炎患者B27的阳性率达91%。普通人群强直性脊柱炎的患病率约为0.1%，在强直性脊柱炎患者的家系中为4%，在B27阳性强直性脊柱炎的患者中，其一级亲属中强直性脊柱炎患病率高达11%-25%。这充分表明B27阳性者或有强直性脊柱炎家族史者患强直性脊柱炎的危险性增加。但是大约80%的B27阳性者并不发生该病，以及大约10%的强直性脊柱炎患者为B27阴性。
β2-微球蛋白：是由淋巴细胞、血小板、多形核白细胞产生的一种小分子球蛋白，相对分子质量为1 1800，由99个氨基酸组成的单链多肽。它是细胞表面人白细胞抗原的β链(轻链)部分，分子内含一对二硫键，不含糖，与免疫球蛋白稳定区的结构相似。广泛存在于血浆、尿液、脑脊液、唾液以及初乳中。
 
摘要
背景：强直性脊柱炎是以侵犯中轴关节为主的慢性炎症自身免疫性疾病，目前发病机制仍不明确。需要进行深入的研究，稳定和成熟的动物模型显得更加重要。强直性脊柱炎脊柱和骶髂生物样本非常的稀缺，然而学者们对该病发病机制的理解很大程度上依赖于强直性脊柱炎动物模型的研究成果，目前的几种强直性脊柱炎动物模型均无法很好的代表强直性脊柱炎的病理病程。
目的：通过总结以往各类强直性脊柱炎动物模型临床和病理特征，为进一步完善此类动物模型提供基础。
方法：以(“Ankylosing Spondylitis” AND “Animal Models”) OR (“HLA-B27” AND “Animal models”)为英文检索词，以(“强直性脊柱炎”AND “动物模型”OR(“人类白细胞抗原B27”AND “动物模型”)为中文检索词，通过检索PubMed/CNKI数据库，排除临床新药研究、动物模型仅为研究手段及未涉及动物模型机制探讨的文章。对目前常见的强直性脊柱炎动物模型发病机制、病理特征进行归纳总结。
结果与结论：纳入综述的文章为37篇。把目前现有的几种强直性脊柱炎动物模型归为3大类，各类动物模型各有其优缺点，它们均能模拟强直性脊柱炎的某些发病特征，但是仍缺乏强直性脊柱炎最具代表性的动物模型，考虑到强直性脊柱炎的发病与肠道菌群密切相关，并将各类动物模型的发病特与之结合，有望复制出更加稳定和完善的强直性脊柱炎动物模型。

中国组织工程研究杂志出版内容重点：人工关节；骨植入物；脊柱；骨折；内固定；数字化骨科；组织工程
ORCID:0000-0002-8147-2186(何羿婷)

关键词: 骨科植入物, 脊柱植入物, 强直性脊柱炎, 动物模型, 人类白细胞抗原B27, 肠道菌群, 作用机制, 国家自然科学基金

Abstract:

BACKGROUND: Ankylosing spondylitis is a chronic inflammatory antoimmune disease involving the axial skeletion. So far, the pathogenesis of the disease is not clear. It still needs to build a more mature and stable animal model to promote further research. Since human tissue specimens of the spine and sacroiliac joint are very difficult to obtain, research has been hinders by limits availability of tissue samples from patients. The understanding of ankylosing spondylitis pathogenesis greatly depends on ankylosing spondylitis animal models. Howerer, the several animal models we have today cannot very good represent ankylosing spondylitis pathogenesis and disease progress. 

OBJECTIVE: To summarize clinical and pathological characteristics of animal models of ankylosing spondylitis to further provide the basis for further improvement of this animal model. 
METHODS: The databases of PubMed/CNKI were retrieved with key words of “Ankylosing Spondylitis, Animal Models, HLA-B27”. We excluded clinical research of new drugs and studies in animal models for the research methods or studies that did not mention the mechanism of animal models. Pathogenesis and pathological characteristics of animal models of ankylosing spondylitis were summarized.
RESULTS AND CONCLUSION: This review included 37 studies and summarized three kinds of animal models of ankylosing spondylitis. All kinds of animal models have their own characteristics and disadvantages. They can simulate some features of ankylosing spondylitis. But to some extent, there is still lack of animal models of representing ankylosing spondylitis. The incidence of ankylosing spondylitis is closely related to the intestinal flora. The combination of different types of animal models is possible to reproduce more stable and perfect animal model of ankylosing spondylitis. 

中国组织工程研究杂志出版内容重点：人工关节；骨植入物；脊柱；骨折；内固定；数字化骨科；组织工程

Key words: Spondylitis, Ankylosing, Models, Animal, HLA Antigens, Tissue Engineering

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