中国组织工程研究 ›› 2017, Vol. 21 ›› Issue (8): 1186-1191.doi: 10.3969/j.issn.2095-4344.2017.08.007

• 口腔组织构建 oral tissue construction • 上一篇    下一篇

富自体浓缩生长因子纤维蛋白液在口腔骨缺损种植引导骨再生后的骨量变化

张  璐1,2,王  频2,郭  玲2,刘  敏2   

  1. 1西南医科大学口腔医学院,四川省泸州市  646000;2西南医科大学附属口腔医院,四川省泸州市  646000
  • 收稿日期:2017-01-16 出版日期:2017-03-18 发布日期:2017-04-14
  • 通讯作者: 刘敏,主任医师,教授,硕士生导师,西南医科大学附属口腔医院修复科,四川省泸州市 646000
  • 作者简介:张璐,女,1990年生,四川省绵阳市人,汉族,西南医科大学口腔医学院在读硕士,主要从事口腔种植义齿修复的基础与临床研究。
  • 基金资助:

    四川省科技厅-泸州市科技局-泸州医学院联合科研项目(14JC0122-LY51);四川省教育厅项目(11ZB128)

Changes of bone mass after concentrated growth factor liquid applied in dental implant surgery with guided bone regeneration

Zhang Lu1, 2, Wang Pin2, Guo Ling2, Liu Min2   

  1. 1School of Stomatology of Southwest Medical University, Luzhou 646000, Sichuan Province, China; 2Stomatological Hospital Affiliated to Southwest Medical University, Luzhou 646000, Sichuan Province, China
  • Received:2017-01-16 Online:2017-03-18 Published:2017-04-14
  • Contact: Liu Min, Chief physician, Professor, Master’s supervisor, Stomatological Hospital Affiliated to Southwest Medical University, Luzhou 646000, Sichuan Province, China
  • About author:Zhang Lu, Studying for master’s degree, School of Stomatology of Southwest Medical University, Luzhou 646000, Sichuan Province, China; Stomatological Hospital Affiliated to Southwest Medical University, Luzhou 646000, Sichuan Province, China
  • Supported by:

    the Combined Research Project of Science & Technology Department of Sichuan Province-Office of Science & Technology of Luzhou-Luzhou Medical University, No. 14JC0122-LY51; the Project of Educational Department of Sichuan Province, No. 11ZB128

摘要:

文章快速阅读:

文题释义:
富自体浓缩生长因子纤维蛋白:是一种取自体静脉血,不添加任何外来物质,通过特殊的变速离心形成三维网状结构的纤维蛋白,内含高度浓缩的生长因子,能促进软硬组织愈合的一种自体生物材料。
引导骨组织再生:通过植入人工骨粉并覆盖胶原膜,诱导骨损伤区的骨再生及骨愈合,具有骨增量和保证种植体在口腔内稳定结合的作用。
摘要
背景:
临床上对于富自体浓缩生长因子纤维蛋白凝胶的成骨作用已有所研究,但是对富自体浓缩生长因子纤维蛋白液的研究较少。
目的:通过观察富自体浓缩生长因子纤维蛋白液体应用于上前牙唇侧骨缺损种植同期引导骨再生后骨量变化,评估富自体浓缩生长因子纤维蛋白液体联合Bio-Oss骨粉在骨增量中的应用效果。
方法:选取单颗上前牙缺失伴唇侧骨缺损患者50例,随机分为试验组和对照组,各25例,2组均采用种植同期引导骨再生的手术方式。试验组使用富自体浓缩生长因子纤维蛋白液体+Bio-Oss骨粉+海奥生物膜进行引导骨再生;对照组使用Bio-Oss骨粉+海奥生物膜进行引导骨再生。
结果与结论:50例患者的种植体愈合情况良好,符合种植体成功的标准。种植后即刻至6个月,2组种植体各位点的唇侧骨量变化差别无显著性意义(P > 0.05);种植后6-12个月,试验组种植体各位点的唇侧骨量变化均小于对照组(P < 0.05)。提示富自体浓缩生长因子纤维蛋白液体联合Bio-Oss骨粉对上前牙缺失伴唇侧骨缺损患者种植疗效较好,富自体浓缩生长因子纤维蛋白液体对减少种植体负载后唇侧骨吸收有一定的积极作用。

中国组织工程研究杂志出版内容重点:组织构建;骨细胞;软骨细胞;细胞培养;成纤维细胞;血管内皮细胞;骨质疏松组织工程
ORCID: 0000-0002-0693-2250(张璐)

关键词: 组织构建, 骨组织工程, 前牙, 骨缺损, 种植, 引导骨再生, 浓缩生长因子, 成骨

Abstract:

BACKGROUND: The osteogenesis effects of concentrated growth factors (CGF) gel have been studied, butlittle has been reported on CGF liquid.
OBJECTIVE: To explore the bone mass changes after CGF is used in the dental implant surgery with guided bone regeneration (GBR) in patients with upper anterior tooth labial bone defect, and to evaluate the effect of CGF liquid combined with Bio-Oss bone meal on bone augmentation.
METHODS: Fifty patients with single anterior tooth labial bone defect were enrolled and randomly divided into experimental and control groups (n=25 per group). Patients in both groups underwent dental implant surgery with GBR. CGF liqiud, Bio-Oss bone meal and biological membrane were used in the experimental group, and Bio-Oss bone meal and biological membrane used in the control group.
RESULTS AND CONCLSUION: All patients healed well according to the successful criteria. Six months postoperatively, there was no significant difference in the thickness changes of labial bone between two groups (P > 0.05). From 6 months to 12 months after operation, the thickness changes of labial bone in the experimental group was significantly less than that in the control group (P < 0.05). Our findings indicate that CGF liquid combined with Bio-Oss bone meal makes good effect on dental implantation of patients with anterior tooth labial bone defect. CGF liquid also contributes to reduce the labial bone resorption of the implant after functional loading.

中国组织工程研究杂志出版内容重点:组织构建;骨细胞;软骨细胞;细胞培养;成纤维细胞;血管内皮细胞;骨质疏松组织工程

Key words: Tooth, Bone Regeneration, Tissue Engineering

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