中国组织工程研究

中国组织工程研究 ›› 2017, Vol. 21 ›› Issue (5): 795-801.doi: 10.3969/j.issn.2095-4344.2017.05.023

• 干细胞综述 stem cell review • 上一篇    下一篇

脂肪干细胞生物学特性及在口腔再生医学中的应用

罗  远1，黄远亮2   

  1. 1同济大学口腔医学院口腔颌面外科教研室，上海牙组织修复与再建工程技术研究中心，上海市  200072
    2同济大学附属东方医院口腔科，上海市  200120
  • 出版日期:2017-02-18 发布日期:2017-03-20
  • 通讯作者: 黄远亮，博士，教授，主任医师，同济大学附属东方医院口腔科，上海市 200120
  • 作者简介:罗远，男，1981年生，河南省新野县人，汉族，同济大学在读博士，主治医师，主要从事口腔颌面外科临床和基础研究。
  • 基金资助:

    上海市科技委员会基金(14411963500)，名称：新型淫羊藿苷缓释支架材料修复种植体周围骨缺损的实验研究；上海市卫计委青年项目(20154Y0200)，名称：富血小板纤维蛋白(PRF)在下颌第三磨牙拔除后第二磨牙远中牙槽嵴保存的应用

The biological features of adipose-derived stem cells and its application in oral tissue regeneration

Luo Yuan1, Huang Yuan-liang2   

  1. 1Department of Oral and Maxillofacial Surgery, the Affiliated Stomatological Hospital of Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai 200072, China
    2Department of Stomatology, Dongfang Hospital of Tongji University, Shanghai 200120, China
  • Online:2017-02-18 Published:2017-03-20
  • Contact: Huang Yuan-liang, M.D., Professor, Chief physician, Department of Stomatology, Dongfang Hospital of Tongji University, Shanghai 200120, China
  • About author:Luo Yuan, Studying for doctorate, Attending physician, Department of Oral and Maxillofacial Surgery, the Affiliated Stomatological Hospital of Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai 200072, China
  • Supported by:

    the Funding Project of Shanghai Science and Technology Committee, No. 14411963500; the Young Project of Shanghai Municipal Commission of Health and Family Planning, No. 20154Y0200

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被引次数

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摘要：

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文题释义：
引导性牙周组织再生术：指在牙周手术中利用膜性材料作为屏障，阻挡牙龈上皮在愈合过程中沿根面生长，阻挡牙龈结缔组织与根面接触，并提供一定的空间，引导具有形成新附着能力的牙周膜细胞优先占领根面，从而在已暴露于牙周袋内的根面上形成新的牙骨质，并有牙周膜纤维埋入，形成牙周组织再生，即形成新附着性愈合。
种植体周围骨缺损：种植体植入后由于各种原因引起的种植体周围骨量和骨高度不足，种植体周围骨缺损分为5类：0：种植体与周围骨质无间隙；Ⅰa：环形骨缺损，间隙≤2 mm；Ⅰb：环形骨缺损，间隙≥2 mm；Ⅱ：三面骨壁；Ⅲ：两面骨壁；Ⅳ：一面骨壁。研究认为，0，Ⅰa，Ⅱ类骨缺损可不进行植骨，而Ⅰb，Ⅲ，Ⅳ类骨缺损需进行植骨。目前主要应用组织工程技术修复种植体周围骨缺损，使种植体周围骨组织再生，促进种植体表面骨结合的形成。

 

摘要
背景：相比较于其他组织来源的干细胞，脂肪干细胞不仅来源广泛，获取方便，而且有强大的扩增和分化潜能，这些特点使其在口腔再生医学中有着广阔的应用前景。
目的：总结脂肪干细胞的生物学特点及其在口腔再生医学中的研究进展。
方法：以“脂肪干细胞，口腔组织再生，骨组织工程；牙周再生；骨缺损；adipose-derived stem cells, oral tissue regeneration, bone tissue engineering, periodontal tissue regeneration, bone defects”为检索词，应用计算机检索PubMed、CNKI、万方数据库2000至2016年的相关文献。
结果与结论：在体外牙周组织再生研究中，脂肪干细胞可以促进骨组织再生、成纤维组织再生、血管组织再生及提高牙周创面愈合能力。在口腔颅颌面骨再生研究中，脂肪干细胞作为种子细胞，可成功修复种植术前的牙槽骨缺损及外伤和肿瘤术后的大面积骨缺失。脂肪干细胞移植后的免疫原性和安全性等问题还需要进一步研究。

 

中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程
ORCID:0000-0001-6902-3970(罗远)

关键词: 干细胞, 脂肪干细胞, 口腔组织再生, 骨组织工程, 牙周再生, 骨缺损

Abstract:

BACKGROUND: In comparison with stem cells from other tissues, adipose-derived stem cells (ADSCs) are not only abundant and easy to harvest but also have the strong abilities to proliferate and differentiate. These make ADSCS the promising stem cells in the field of oral tissue regeneration.
OBJECTIVE: To summarize the biological features of ADSCs and the development of functions as stem cells in the oral tissue regeneration.
METHODS: We took “adipose-derived stem cells, oral tissue regeneration, bone tissue engineering, periodontal tissue regeneration, bone defects” as the key words in Chinese and English, respectively, to retrieve the related literatures from PubMed, CNKI, Wangfang databases during 2000 to 2016 based on internet search.
RESULTS AND CONCLUSION: In vitro studies on periodontal tissue regeneration have shown that ADSCs can promote the regeneration of bones, fibroblasts, blood vessels around the periodontal area, and improve the healing abilities of injured tissues. In the study of craniofacial bone regeneration, ADSCs can successfully repair massive bone loss due to the surgeries of tumor or accidents. ADSCs have a promising role in the oral tissue regeneration, but further studies will be required because of the problems of immunogenicity and safety.

 

中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程

Key words: Stem Cells, Adipose Tissue, Guided Tissue Regeneration, Periodontal, Tissue Engineering

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