中国组织工程研究

中国组织工程研究 ›› 2015, Vol. 19 ›› Issue (51): 8208-8212.doi: 10.3969/j.issn.2095-4344.2015.51.002

• 骨组织构建 bone tissue construction • 上一篇    下一篇

缓激肽B2受体基因多态性对膝关节骨关节炎易感性的影响

冯 晖1，冯 虎2，郭开今2，陈 烁3，袁 峰2   

  1. 1徐州医学院研究生学院，江苏省徐州市   221000；2徐州医学院附属医院骨科，江苏省徐州市 221000；3解放军南京军区南京总医院骨科，江苏省南京市 210002
  • 收稿日期:2015-10-28 出版日期:2015-12-10 发布日期:2015-12-10
  • 通讯作者: 袁峰，博士，主任医师, 徐州医学院附属医院骨科，江苏省徐州市 221000 并列通讯作者：陈烁，博士，主治医师，解放军南京军区南京总医院骨科，江苏省南京市 210002
  • 作者简介:冯晖，男，1979年生，安徽省蚌埠市人，徐州医学院在读硕士，主治医师，主要从事关节外科临床及科研工作。
  • 基金资助:

    国家自然科学基金资助项目(81301582)；全军医学科技青年培育项目(13QNP044)；中国博士后科学基金资助项目(2015M572812)；江苏省临床医学科技专项资助(BL2012002)

Bradykinin B2 receptor gene polymorphisms influence the susceptibility of knee osteoarthritis 

Feng Hui1, Feng Hu2, Guo Kai-jin2, Chen Shuo3, Yuan Feng2   

  1. 1Graduate School of Xuzhou Medical College, Xuzhou 221000, Jiangsu Province, China; 2Department of Orthopedics, Affiliated Hospital of Xuzhou Medical College, Xuzhou 221000, Jiangsu Province, China; 3Department of Orthopedics, Nanjing General Hospital of Nanjing Military Command, Nanjing 210002, Jiangsu Province, China
  • Received:2015-10-28 Online:2015-12-10 Published:2015-12-10
  • Contact: Yuan Feng, M.D., Chief physician, Department of Orthopedics, Affiliated Hospital of Xuzhou Medical College, Xuzhou 221000, Jiangsu Province, China Corresponding author: Chen Shuo, M.D., Attending physician, Department of Orthopedics, Nanjing General Hospital of Nanjing Military Command, Nanjing 210002, Jiangsu Province, China
  • About author:Feng Hui, Studying for Master’s degree, Attending physician, Graduate School of Xuzhou Medical College, Xuzhou 221000, Jiangsu Province, China
  • Supported by:

    the National Natural Science Foundation of China, No. 81301582; Military Medical Development  
    Project for the Youth, No. 13QNP044; China Postdoctoral Science Foundation, No. 2015M572812; the Clinical Medicine Scientific Special Fund of Jiangsu Province, No. BL2012002

PDF

361

被引次数

3

摘要：

背景：据报道在膝骨关节炎患者中应用缓激肽B2受体拮抗剂能产生持久的镇痛效果，缓激肽B2受体(BDKRB2)在骨关节炎的发展中具有重要作用。
目的：进一步明确缓激肽B2受体基因多态性与骨关节炎易感性的相关性。
方法：共有278例膝关节骨关节炎患者和291名健康志愿者参与试验。测定受试对象的缓激肽B2受体基因多态性，根据基因型和放射学分型进行统计学处理。
结果与结论：骨关节炎组和对照组中+9/-9 bp多态性的基因型分布和等位基因频率差异明显。-9/-9 bp 多态性和+9/+9 bp相比，与骨关节炎的罹患风险和严重程度存在明显相关性。-9 bp 等位基因的表达，与骨关节炎的Kellgren-Lawrence分型相关。结果提示缓激肽B2受体基因+9/-9 bp多态性可能成为骨关节炎易感性和严重性筛查的分子标记。
 

关键词: 组织构建, 骨组织工程, 缓激肽受体B2(BDKRB2), 骨关节炎, 基因多态性, 国家自然科学基金

Abstract:

BACKGROUND: It has been reported that bradykinin B2 receptor (BDKRB2) antagonists can produce long-lasting analgesic effect in patients with knee osteoarthritis, and BDKRB2 plays an important role in the development of osteoarthritis.
OBJECTIVE: To further verify the association BDKRB2 polymorphisms and osteoarthritis susceptibility.
METHODS: 278 patients with primary knee osteoarthritis and 291 healthy volunteers as controls were enrolled. BDKRB2 gene polymorphisms were genotyped.
RESULTS: The genotype distributions and allele frequencies of +9/-9 bp polymorphisms significantly differed between osteoarthritis patients and healthy controls. The -9/-9 polymorphisms were significantly associated with the increased risk and the radiographic severity of knee osteoarthritis compared to the +9/+9 genotype. The presence of -9 bp was associated with higher Kellgren-Lawrence grade in knee osteoarthritis. These findings suggest that the +9/-9 bp polymorphisms of BDKRB2 gene may be used as a molecular marker for the susceptibility and severity of knee osteoarthritis.
 

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