[1] Moran CJ, Pascual-Garrido C, Chubinskaya S,et al.Restoration of articular cartilage.J Bone Joint Surg Am. 2014;96(4):336-344.
[2] Gopal K, Amirhamed HA, Kamarul T.Advances of human bone marrow-derived mesenchymal stem cells in the treatment of cartilage defects: A systematic review.Exp Biol Med (Maywood). 2014;239(6):663-669.
[3] Bagaria V, Patil N, Sapre V,et al.Stem cells in orthopedics: current concepts and possible future applications.Indian J Med Sci. 2006;60(4):162-169.
[4] Kim IY, Seo SJ, Moon HS,et al.Chitosan and its derivatives for tissue engineering applications.Biotechnol Adv. 2008;26(1): 1-21.
[5] Chung R, Wong D, Macsai C,et al.Roles of Wnt/β-catenin signalling pathway in the bony repair of injured growth plate cartilage in young rats.Bone. 2013;52(2):651-658.
[6] Mara CS, Duarte AS, Sartori A,et al.Regulation of chondrogenesis by transforming growth factor-beta 3 and insulin-like growth factor-1 from human mesenchymal umbilical cord blood cells.J Rheumatol. 2010;37(7):1519- 1526.
[7] Li J, Zhao Z, Liu J,et al.MEK/ERK and p38 MAPK regulate chondrogenesis of rat bone marrow mesenchymal stem cells through delicate interaction with TGF-beta1/Smads pathway. Cell Prolif. 2010;43(4):333-343.
[8] Cai J, Deng L.Regulations of Hedgehog signaling pathway on mesenchymal stem cells.Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2010;24(8):993-996.
[9] Plaisant M, Giorgetti-Peraldi S, Gabrielson M,et al.Inhibition of hedgehog signaling decreases proliferation and clonogenicity of human mesenchymal stem cells.PLoS One. 2011;6(2):e16798.
[10] Ehlen HW, Buelens LA, Vortkamp A.Hedgehog signaling in skeletal development.Birth Defects Res C Embryo Today. 2006;78(3):267-279.
[11] Zhang XM, Ramalho-Santos M, McMahon AP.Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node.Cell. 2001;106(2):781-792.
[12] Ikram MS, Neill GW, Regl G,et al.GLI2 is expressed in normal human epidermis and BCC and induces GLI1 expression by binding to its promoter.J Invest Dermatol. 2004;122(6): 1503-1509.
[13] Chen MH, Wilson CW, Chuang PT.SnapShot: hedgehog signaling pathway.Cell. 2007;130(2):386.
[14] Kellner K, Lang K, Papadimitriou A,et al. Effects of hedgehog proteins on tissue engineering of cartilage in vitro.Tissue Eng. 2002;8(4):561-572.
[15] Li X, Wei G, Wang X,et al.Targeting of the Sonic Hedgehog pathway by atractylenolides promotes chondrogenic differentiation of mesenchymal stem cells.Biol Pharm Bull. 2012;35(8):1328-1335.
[16] Wu X, Cai ZD, Lou LM,et al.The effects of inhibiting hedgehog signaling pathways by using specific antagonist cyclopamine on the chondrogenic differentiation of mesenchymal stem cells.Int J Mol Sci. 2013;14(3):5966-5977.
[17] Wu X, Li SH, Lou LM,et al.The effect of the microgravity rotating culture system on the chondrogenic differentiation of bone marrow mesenchymal stem cells.Mol Biotechnol. 2013; 54(2):331-336.
[18] 王明霞, 黄建林, 朱尚玲,等. 类风湿关节炎患者外周血单个核细胞Sonic Hedgehog信号通路表达的初步研究[J]. 中国病理生理杂志, 2012,28(3):483-487.
[19] St-Jacques B, Hammerschmidt M, McMahon AP.Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation.Genes Dev. 1999;13(16):2072-2086.
[20] Fischer J, Aulmann A, Dexheimer V,et al.Intermittent PTHrP(1-34) Exposure Augments Chondrogenesis and Reduces Hypertrophy of Mesenchymal Stromal Cells.Stem Cells Dev. 2014. [Epub ahead of print
[21] Fischer J, Dickhut A, Rickert M,et al.Human articular chondrocytes secrete parathyroid hormone-related protein and inhibit hypertrophy of mesenchymal stem cells in coculture during chondrogenesis.Arthritis Rheum. 2010;62(9): 2696-2706.
[22] Mak KK, Kronenberg HM, Chuang PT,et al. Indian hedgehog signals independently of PTHrP to promote chondrocyte hypertrophy.Development. 2008;135(11):1947-1956.
[23] Steinert AF, Weissenberger M, Kunz M,et al.Indian hedgehog gene transfer is a chondrogenic inducer of human mesenchymal stem cells.Arthritis Res Ther. 2012;14(4):R168.
[24] Zeng L, Kempf H, Murtaugh LC,et al.Shh establishes an Nkx3.2/Sox9 autoregulatory loop that is maintained by BMP signals to induce somitic chondrogenesis.Genes Dev. 2002; 16(15):1990-2005.
[25] Warzecha J, Göttig S, Brüning C,et al.Sonic hedgehog protein promotes proliferation and chondrogenic differentiation of bone marrow-derived mesenchymal stem cells in vitro.J Orthop Sci. 2006;11(5):491-496.
[26] Kawato Y, Hirao M, Ebina K,et al.Nkx3.2-induced suppression of Runx2 is a crucial mediator of hypoxia-dependent maintenance of chondrocyte phenotypes.Biochem Biophys Res Commun. 2011;416(1-2):205-210.
[27] 张雪萍, 马晓丽, 汪运山, 等.大鼠骨髓间充质干细胞成骨分化过程中Hedgehog信号分子的表达[J]. 中国组织工程研究与临床康复,2011;15(14):2487-2490.
[28] Wu LN, Lu M, Genge BR,et al.Discovery of sonic hedgehog expression in postnatal growth plate chondrocytes: differential regulation of sonic and Indian hedgehog by retinoic acid.J Cell Biochem. 2002;87(2):173-187.
[29] 陈美玲, 曹颖光. Sonic hedgehog基因对犬下颌骨种植体周围骨缺损修复的影响[C]. 武夷山:中华口腔医学会口腔生物医学专业委员会口腔颌面发育和再生医学学术会议论文集, 2011: 67-68.
[30] Mak KK, Chen MH, Day TF,et al.Wnt/beta-catenin signaling interacts differentially with Ihh signaling in controlling endochondral bone and synovial joint formation.Development. 2006;133(18):3695-3707.
[31] Iwakura T, Inui A, Reddi AH.Stimulation of superficial zone protein accumulation by hedgehog and Wnt signaling in surface zone bovine articular chondrocytes.Arthritis Rheum. 2013;65(2):408-417.
[32] Murtaugh LC, Chyung JH, Lassar AB.Sonic hedgehog promotes somitic chondrogenesis by altering the cellular response to BMP signaling.Genes Dev. 1999;13(2):225-237.
[33] Kawai S, Sugiura T.Characterization of human bone morphogenetic protein (BMP)-4 and -7 gene promoters: activation of BMP promoters by Gli, a sonic hedgehog mediator. Bone. 2001;29(1):54-61.
[34] Zhou J, Meng J, Guo S,et al.IHH and FGF8 coregulate elongation of digit primordia.Biochem Biophys Res Commun. 2007;363(3):513-518.
[35] 张树威,金伟,祝少博,等.甲状旁腺素相关蛋白亚基因对骨骺干细胞的调控[J].中国组织工程研究,2013,17(10):1814-1820.
[36] Kim EJ, Cho SW, Shin JO,et al.Ihh and Runx2/Runx3 signaling interact to coordinate early chondrogenesis: a mouse model.PLoS One. 2013;8(2):e55296. |