中国组织工程研究

中国组织工程研究 ›› 2014, Vol. 18 ›› Issue (15): 2421-2426.doi: 10.3969/j.issn.2095-4344.2014.15.021

• 组织构建基础实验 basic experiments in tissue construction • 上一篇    下一篇

弥散张量成像显示亚急性期脑梗死神经网络损伤及各运动参数分析

肖  湘1，2，李  乐1，吕衍春3，林  强1，黄东锋1   

  1. 1中山大学附属第一医院康复医学科，广东省广州市  510080；2深圳市第五人民医院(罗湖区人民医院)康复医学科，广东省深圳市  518001；3中山大学附属肿瘤防治中心影像与微创介入中心，广东省广州市  510060
  • 出版日期:2014-04-09 发布日期:2014-04-09
  • 通讯作者: 黄东锋，教授，博士生导师，中山大学附属第一医院康复医学科，广东省广州市 510080
  • 作者简介:肖湘，女，1976年生，湖南省益阳市人，汉族，2012年中山大学毕业，博士，主治医师，主要从事神经康复的研究。

Xiao Xiang 1, 2, Li Le1, Lv Yan-chun3, Lin Qiang1, Huang Dong-feng1   

  1. 1 Department of Rehabilitation Medicine, First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China;
    2 Department of Rehabilitation Medicine, the Fifth People’s Hospital of Shenzhen (Shenzhen Luohu People’s Hospital), Shenzhen 518001, Guangdong Province, China; 3 Department of Imaging & Interventional Radiology, Cancer Center, Sun Yat-sen University, Guangzhou 510060, Guangdong Province, China
  • Online:2014-04-09 Published:2014-04-09
  • Contact: Huang Dong-feng, Professor, Doctoral supervisor, Department of Rehabilitation Medicine, First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China
  • About author:Xiao Xiang, M.D., Attending physician, Department of Rehabilitation Medicine, First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China; Department of Rehabilitation Medicine, the Fifth People’s Hospital of Shenzhen (People’s Hospital in Luohu District), Shenzhen 518001, Guangdong Province, China
  • Supported by:

    the National Natural Science Foundation of China, No. 30973165

PDF

454

被引次数

8

摘要：

背景：脑卒中后神经网络与运动功能的相关性尚未明确。
目的：应用磁共振弥散张量成像研究亚急性期脑梗死后神经网络受损情况，并分析其与神经功能缺陷及运动功能障碍的相关性。
方法：将19例亚急性期脑梗死患者和20名正常成人分别进行弥散张量成像检查，分析比较以下参数：各向异性分数、表观扩散系数和各向异性分数指数、表观扩散系数指数。同时对患者进行神经功能缺损和运动功能的各项量表评估，检测10 m步行速度。将脑梗死患者弥散张量成像的各项参数与各项量表及10 m步行速度进行相关性分析。
结果与结论：脑梗死患者各向异性分数指数和双侧内囊后肢的各向异性分数值均小于正常对照，且患侧内囊后肢的各向异性分数值小于健侧内囊后肢的各向异性分数值(P < 0.05)。患侧内囊后肢的表观扩散系数值、表观扩散系数指数大于正常对照内囊后肢的表观扩散系数值和表观扩散系数指数(P < 0.05)。患侧内囊后肢的表观扩散系数值、表观扩散系数指数与下肢Fugl-Meyer评分呈负相关(P < 0.05)。提示弥散张量成像参数与下肢运动功能障碍密切相关。脑卒中后的局灶性病变造成神经网络缺损，是下肢运动功能障碍的主要原因。



中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程


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Abstract:

BACKGROUND: The interaction of neural network and motor function in post-stroke brain tissue remains unclear.
OBJECTIVE: To observe neural network impairment following subacute stroke by using diffusion tensor imaging, and to investigate the relationship with neurological defects and motor dysfunction.
METHODS: A total of 19 patients after subactue stroke and 20 healthy adults were examined with diffusion tensor imaging. The following parameters were compared: fractional anisotropy, apparent diffusion coefficient, asymmetry indices of fractional anisotropy and apparent diffusion coefficient. The neurological defect and motor function were evaluated with the corresponding scales. The 10-meter walking speed was measured. The correlation of diffusion tensor imaging parameters with the scale scores and 10-meter walking speed was analyzed.
RESULTS AND CONCLUSION: The stroke group exhibited reduced fractional anisotropy value asymmetry and fractional anisotropy value in bilateral posterior limbs of the internal capsule. Apparent diffusion coefficient value asymmetry and apparent diffusion coefficient value in the posterior limb of the internal capsule were lower than control unaffected side (P < 0.05). Apparent diffusion coefficient value and apparent diffusion coefficient value asymmetry in posterior limb of the internal capsule showed a strong negative correlation with Fugl-Meyer  assessment scores of the lower extremities (P < 0.05). Diffusion tensor imaging parameters is closely linked with motor dysfunction of the lower extremities in subacute stroke patients. Local stroke lesion-caused neurological defect is the leading cause of motor dysfunction of the lower extremities.



中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程


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