中国组织工程研究 ›› 2013, Vol. 17 ›› Issue (1): 167-172.doi: 10.3969/j.issn.2095-4344.2013.01.027

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

细胞因子修饰的间充质干细胞

王 鲲,哈小琴   

  1. 解放军兰州军区总医院检验科,甘肃省兰州市 730050
  • 收稿日期:2012-04-28 修回日期:2012-05-18 出版日期:2013-01-01 发布日期:2013-01-01
  • 通讯作者: 哈小琴,博士,主任医师,解放军兰州军区兰州总医院检验科,甘肃省兰州市 730050 Haxq@yahoo.com
  • 作者简介:王鲲★,男,1987年生,安徽省合肥市人,汉族,甘肃农业大学在读硕士,主要从事预防兽医、干细胞方面的研究。163wk1029r@163.com
  • 基金资助:

    全军十二五面上项目(CWS11C229):西北高寒战区战创再生修复及功能重建的实用技术研究。

Research and clinical application of mesenchymal stem cells modified by cytokines

Wang Kun, Ha Xiao-qin   

  1. Department of Laboratory Medicine, the General Hospital of Lanzhou Military Area Command of Chinese PLA, Lanzhou 730050, Gansu Province, China
  • Received:2012-04-28 Revised:2012-05-18 Online:2013-01-01 Published:2013-01-01
  • Contact: Ha Xiao-qin, M.D., Chief physician, Department of Laboratory Medicine, the General Hospital of Lanzhou Military Area Command of Chinese PLA, Lanzhou 730050, Gansu Province, China Haxq@yahoo.com
  • About author:Wang Kun★, Studying for master’s degree, Department of Laboratory Medicine, the General Hospital of Lanzhou Military Area Command of Chinese PLA, Lanzhou 730050, Gansu Province, China 163wk1029r@163.com
  • Supported by:

    Supported by: the Medical Science and Technology Foundation of Chinese PLA during Twelfth "Five-Year" Development Period (General Program), No.CWS11C229

摘要:

背景:将细胞治疗与基因治疗相结合,通过不同的细胞因子对间充质干细胞的修饰,不但可以赋予其新的能力,更能增强其本身的功能。但是在西北高原的低氧环境下,间充质干细胞的功能发挥就会受到一定的限制。
目的:文章综述了间充质干细胞近年来的研究进展,在与细胞因子联合应用后功能上的扩展,并寻找新的手段使其在高原低氧环境下充分发挥功能。
方法:应用计算机检索CNKI数据库和PUBMED数据库中关于间充质干细胞的文章,以“间充质干细胞;低氧诱导因子;肝细胞生长因子”或“mesenchymal stem cells; hypoxia inducible factor;hepatocyte growth factor”为检索词进行检索。检索文献总量为71篇,选择文章内容与间充质干细胞及其临床应用有关方面的文章,同一领域文献则选择近期发表或发表在权威杂志文章。
结果与结论:最终纳入35篇符合标准的文献。通过应用细胞因子的转染,将细胞因子的功能与间充质干细胞相结合,使得间充质干细胞的功能更全面,在高原低氧的恶劣环境下,依然能够有效的发挥临床效用,满足其临床上的治疗需求。

关键词: 干细胞, 干细胞综述, 间充质干细胞, 组织修复, 细胞因子, 低氧诱导因子, 肝细胞生长因子, 其他基金

Abstract:

BACKGROUND: Cell therapy combined with gene therapy in which mesenchymal stem cells can be modified by different cytokines can capacitate mesenchymal stem cells and enhance their functions. But mesenchymal stem cell function will be restricted in the northwest plateau hypoxia environment.
BJECTIVE: To review the research progress in mesenchymal stem cells, and cell function expansion after combined application of cytokines, and search a new means to give full play to cell function in the highaltitude hypoxia environment.
METHODS: Articles involving mesenchymal stem cells were searched in CNKI database and PUBMED database through computer, with the keywords “mesenchymal stem cells, hypoxia inducible factor, hepatocyte growth factor”. A total of 71 articles were retrieved. Articles regarding mesenchymal stem cells and their clinical application were selected. The articles published recently in high impact factor journals were selected in the same field.
RESULTS AND CONCLUSION: Finally, there are 30 articles selected according to the standard. Through cytokine transfection, mesenchymal stem cells are endowed with new abilities, which enrich the function of mesenchymal stem cells and play an effective role in clinical treatment, in particular in the high altitude hypoxia environment.

Key words: stem cells, stem cell review, mesenchymal stem cells, tissue repair, cytokines, hypoxia inducible factor, hepatocyte growth factor, other grants-supported paper

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