中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (44): 8271-8278.doi: 10.3969/j.issn.2095-4344.2012.44.020

• 骨与关节综述 bone and joint review • 上一篇    下一篇

血液炎性标志物用于关节假体感染诊断的研究与应用

谢 强，雷光华   

  1. 中南大学湘雅医学院骨外科系，湖南省长沙市 410008
  • 收稿日期:2012-07-11 修回日期:2012-07-17 出版日期:2012-10-28 发布日期:2012-10-28
  • 通讯作者: 雷光华，博士、教授、主任医师、博士生导师。中南大学湘雅医学院骨外科系，湖南省长沙市 410008 lgh9640@sina.com
  • 作者简介:谢强★，男，1986年生，河北省承德市人，蒙古族，中南大学湘雅医院在读硕士，主要从事骨关节退变的发病机制及治疗方面的研究。 554398579@qq.com

Blood inflammatory markers for the diagnosis of joint prosthesis infection

Xie Qiang, Lei Guang-hua   

  1. Department Orthopedic Surgery, Xiangya School of Medicine, Central South University, Changsha 410008, Hunan Province, China
  • Received:2012-07-11 Revised:2012-07-17 Online:2012-10-28 Published:2012-10-28
  • Contact: Lei Guang-hua, Doctor, Professor, Chief physician, Doctoral supervisor, Department Orthopedic Surgery, Xiangya School of Medicine, Central South University, Changsha 410008, Hunan Province, China lgh9640@sina.com
  • About author:Xie Qiang★, Studying for master’s degree, Department Orthopedic Surgery, Xiangya School of Medicine, Central South University, Changsha 410008, Hunan Province, China 554398579@qq.com

PDF

436

被引次数

9

摘要：

背景：人工关节置换作为一种成熟的治疗方法现已在国内外广泛应用，关节假体感染是人工关节置换后严重的并发症之一，感染后将给患者带来严重后果。目前，对假体感染的诊断还没有一项临床或实验室检查在灵敏度、特异度和精确度上达到令人满意的程度。
目的：讨论并总结人工关节置换后假体感染的相关血液炎性标志物诊断方法。
方法：由第一作者用计算机检索中国期刊全文数据库(CNKI：2002至2012年)和PubMed(2002至2012年)数据库，检索词分别为“关节置换、假体感染、诊断、实验室检查”和“joint replacement prosthesis infection, diagnosis, laboratory tests”。从寻找关节置换后假体感染的临床表现及相关诊断方法上进行相关介绍及总结。共检索到153篇文章，按纳入和排除标准对文献进行筛选，共纳入30篇文章。
结果与结论：白细胞介素6血清水平对于诊断关节假体感染准确性最高，之后依次是C-反应蛋白，红细胞沉降率，白细胞计数。然而，常规检查白细胞介素6条件还是有限，进一步评估白细胞介素6和其他细胞因子在不同的患者身上诊断关节假体感染的准确性还需要更深入的研究。

关键词: 关节置换, 感染, 白细胞介素6, 全髋关节置换, 诊断, 实验室检查, 细菌生物膜, 组织工程

Abstract:

BACKGROUND: Artificial joint replacement as a proven treatment method is now widely used at home and abroad, and the joint prosthesis infection is one of the serious complications of artificial joint replacement surgery. Once the infection occurred, patients will have serious consequences. At present, there is no clinical or laboratory tests that people is satisfied at the sensitivity, specificity and accuracy.
OBJECTIVE: To discuss and summarize the blood inflammatory markers diagnostic methods of prosthesis infection after artificial joint replacement.
METHODS: First author searched the literature from CNKI database (2002/2012) and PubMed database (2002/2012) with the key words of “joint replacement, prosthesis infection, diagnosis, laboratory tests” in Chinese or English. The introduction and summary literatures that related to clinical manifestation and diagnosis of prosthesis infection after joint replacement were searched. A total of 153 literatures were screened out, and 30 literatures were included according to the inclusion and exclusion criteria.
RESULTS AND CONCLUSION: The results showed that serum interleukin-6 levels have the highest accuracy for the diagnosis of joint prosthesis infection, followed by C-reactive protein, erythrocyte sedimentation rate, leukocyte count. However, the routine examination of interleukin-6 is limited, to further assess the accuracy of interleukin-6 and other cytokines for the diagnosis of joint prosthesis infection in different patients also need more in-depth research.

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