中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (43): 7991-7994.doi: 10.3969/j.issn.2095-4344.2012.43.003

• 组织工程骨及软骨材料 tissue-engineered bone and cartilage materials • 上一篇    下一篇

新型种植体骨界面Ⅰ型胶原的表达

何 芸1，陈俊良1，刘福祥2，古亚兰1   

  1. 1泸州医学院附属口腔医院，四川省泸州市 646000
    2四川大学华西口腔医院种植科，四川省成都市 610041
  • 收稿日期:2012-02-19 修回日期:2012-04-13 出版日期:2012-10-21 发布日期:2012-10-21
  • 通讯作者: 陈俊良，硕士，泸州医学院附属口腔医院，四川省泸州市 646000
  • 作者简介:何芸★，女，1981年生，四川省宜宾市人，汉族，2007年四川大学华西口腔医学院毕业，硕士，讲师，主要从事口腔种植研究。 heyundaidai@ 163.com

Expression of type Ⅰ collagen in the new-type implant-bone interface

He Yun 1, Chen Jun-liang1, Liu Fu-xiang2, Gu Ya-lan1   

  1. 1Affiliated Stomatological Hospital of Luzhou Medical College, Luzhou 646000, Sichuan Province, China
    2Department of Implantation, West China Stomatological Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China
  • Received:2012-02-19 Revised:2012-04-13 Online:2012-10-21 Published:2012-10-21
  • Contact: Chen Jun-liang, Master, Affiliated Stomatological Hospital of Luzhou Medical College, Luzhou 646000, Sichuan Province, China
  • About author:He Yun★, Master, Lecturer, Affiliated Stomatological Hospital of Luzhou Medical College, Luzhou 646000, Sichuan Province, China heyundaidai@ 163.com

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摘要：

背景：刘福祥教授自行设计的新型种植体在较短种植体长度上给出了较大骨接触面积，同时考虑到种植体的抗扭转能力、抗侧向力能力，种植体与骨弹性模量的匹配及加工和植入、修复的便易度。
目的：观察自主设计的新型种植体植入颌骨后种植体-骨界面Ⅰ型胶原的表达变化，探讨新型种植体与牙槽骨的骨结合能力。
方法：拔除成年狼犬双侧下颌前磨牙3个月后，于两侧拔牙位点牙槽骨分别植入新型种植体和圆柱状种植体各2枚。
结果与结论：随时间增加两组周围骨组织密度逐渐升高，新型种植体组圆盘结构间出现密度逐渐升高的影像组织。两组种植体-骨界面均有Ⅰ型胶原表达，均于术后4周达高峰，且新型种植体组术后2，4周Ⅰ型胶原平均灰度值均高于圆柱状种植体组(P < 0.05)。表明新型种植体植入颌骨后能够取得生物性成功，种植体-骨界面成骨较圆柱状种植体更快，更活跃，骨结合能力更强。

关键词: Ⅰ型胶原, 新型种植体, 骨结合, 种植体-骨界面, 颌骨, 生物材料

Abstract:

BACKGROUND: The new type implant designed by Professor Liu integrates the character of cylinder implant and blade implant. It is shorter but bigger in contact area. The design of new type implant is considered the torsional capacity, lateral force resisting ability, the match of implant and bone elastic modulus, as well as processing and implantation and repair convenience.
OBJECTIVE: To investigate the changes of type Ⅰ collagen expression in the implant-bone interfaces after implanted to the jawbone, and to explore the combining capacity of the new type implant and alveolar bone.
METHODS: All the premolars in the bilateral jaw of six adult dogs were extracted. Three months later,two new type implants and two cylinder implants were implanted to the sockets and divided to the new type implants group and cylinder implants group.
RESULTS AND CONCLUSION: The density of the guided bone tissue in the two groups was increased with time. The tissues with gradually increased density in the disk structure of the new type implant group were found. The expression of type Ⅰ collagen was found in the implant-bone interfaces of the two groups, and both reached the peak at week 4 after surgery. The mean gray value of the new type implant group at weeks 2 and 4 after surgery was higher than that of the cylinder implants group (P < 0.05). These findings suggest that new type implant can achieve success after implanted into the jaw bone due to its special design. The osseointegration of the new type implant is earlier, more active and stronger combining capacity than that of the cylinder implant.

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