中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (38): 7111-7115.doi: 10.3969/j.issn.2095-4344.2012.38.017

• 药物控释材料 drug delivery materials • 上一篇    下一篇

聚乙二醇选择性接枝壳聚糖共聚生物材料

李若慧，单丹彤，张国华，袁志奎   

  1. 北京联合大学生物化学工程学院，北京市 100023
  • 收稿日期:2012-01-08 修回日期:2012-01-21 出版日期:2012-09-16 发布日期:2012-09-16
  • 作者简介:李若慧★，女，北京市人，汉族，1991年天津大学毕业，硕士，副教授，主要从事生物高分子材料的教学和研究工作。 ruohui27@ sina.com

Copolymer biomaterial of chitosan selectively grafted by poly(ethylene glycol)

Li Ruo-hui, Shan Dan-tong, Zhang Guo-hua, Yuan Zhi-kui   

  1. Biochemical Engineering College of Beijing Union University, Beijing 100023, China
  • Received:2012-01-08 Revised:2012-01-21 Online:2012-09-16 Published:2012-09-16
  • About author:Li Ruo-hui★, Master, Associate professor, Biochemical Engineering College of Beijing Union University, Beijing 100023, China ruohui27@sina.com

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摘要：

背景：聚乙二醇具有良好的水溶性和生物相容性，兼具亲水性与柔韧性，是改善大分子材料水溶性的常用材料。
目的：把聚乙二醇接枝到壳聚糖的大分子链上，改善壳聚糖的亲水性。
方法：使用铜离子对壳聚糖大分子上的氨基进行保护，将甲氧基聚乙二醇的端羟基与六亚甲基二异氰酸酯缩合成端基为异氰酸酯的聚乙二醇大分子单体，进而与保护后的壳聚糖链节上的羟基进行选择性地缩合接枝共聚反应，合成聚乙二醇接枝壳聚糖共聚物。观察甲氧基聚乙二醇的用量对接枝率、接枝效率及其在水中的溶胀性质的影响。
结果与结论：甲氧基聚乙二醇的用量越多，接枝率越高；当甲氧基聚乙二醇/壳聚糖质量比为5，接枝效率达到最大，为24%；当甲氧基聚乙二醇/壳聚糖质量比为8.75时，平衡溶胀度最高可以达到120%；在水中浸泡同样的时间，甲氧基聚乙二醇的用量越多，聚乙二醇接枝壳聚糖共聚物的溶胀能力越强。

关键词: 壳聚糖, 聚乙二醇, 接枝共聚, 接枝率, 溶胀性质

Abstract:

BACKGROUND: Polyethylene glycol has been generally applied to improving water solubility of macromolecular materials not only for its favourable water solubility and biocompatibility but also for its hydrophily and flexibility.
OBJECTIVE: To improve chitosan hydrophily by selectively grafting polyethylene glycol to chitosan molecule chain.
METHODS: First, amino groups on chitosan chains were protected by copper ion. Second, the monomethoxy polyethylene glycol which hydroxyl was combined with hexamethylene diisocyanate became a novel macromonomer namely monomethoxy polyethylene glycol isocyanate. And then, the hydroxyl group of chitosan was selectively grafted by the macromonomer. Finally, the copolymer of chitosan grafted by poly(ethylene glycol) was synthesized. The effects of monomethoxy polyethylene glycol dosage on grafting ratio, grafting efficiency and swelling properties of chitosan grafted by poly(ethylene glycol) in water were studied.
RESULTS AND CONCLUSION: The graft ratio was increased with the increase of the amount of monomethoxy polyethylene glycol. Grafting efficiency reached the maximum, and it was about 24%, when the mass ratio of monomethoxy polyethylene glycol to chitosan was about 5. Equilibrium swelling degree was up to above 120%, when mass ratio of monomethoxy polyethylene glycol to chitosan was about 8.75. These findings suggest that the more the amount of the monomethoxy polyethylene glycol, the stronger was the swelling ability when chitosan grafted by poly(ethylene glycol) was soaked for the same time in water.

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