中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (38): 7092-7095.doi: 10.3969/j.issn.2095-4344.2012.38.013

• 抗菌抗病毒材料 antibacterial and antiviral materials • 上一篇    下一篇

含锌羟基磷灰石二氧化钛复合涂层的抗菌性能

张静莹1，孙慎霞1，齐 民2，艾红军3   

  1. 1大连大学医学院，辽宁省大连市 116622
    2大连理工大学材料科学与工程学院，辽宁省大连市 116024
    3中国医科大学口腔医学院，辽宁省沈阳市 110001
  • 收稿日期:2012-01-30 修回日期:2012-02-23 出版日期:2012-09-16 发布日期:2012-09-16
  • 作者简介:张静莹☆，女，1978年生，辽宁省大连市人，汉族，2011年中国医科大学毕业，博士，讲师，主要从事种植体表面改性方面的研究。 jingying78@ gmail.com

Antibacterial property of a zinc-containing hydroxyapatite/titania hybrid coating

Zhang Jing-ying1, Sun Shen-xia1, Qi Min2, Ai Hong-jun3   

  1. 1School of Medicine, Dalian University, Dalian 116622, Liaoning Province, China
    2School of Materials Science and Engineering, Dalian University of Technology, Dalian 116024, Liaoning Province, China
    3School of Stomatology, China Medical University, Shenyang 110001, Liaoning Province, China
  • Received:2012-01-30 Revised:2012-02-23 Online:2012-09-16 Published:2012-09-16
  • About author:Zhang Jing-ying☆, Doctor, Lecturer, School of Medicine, Dalian University, Dalian 116622, Liaoning Province, China jingying78@ gmail.com

PDF

687

被引次数

10

摘要：

背景：提高钛种植体的抗菌性能，降低种植体周围炎的发生，是提高钛种植体成功率的有效方法。
目的：观察含锌羟基磷灰石二氧化钛复合涂层的抗菌性能。
方法：在纯钛表面先通过微弧氧化方法形成多孔二氧化钛，然后通过溶胶-凝胶法在其上形成含锌羟基磷灰石二氧化钛生物涂层。采用电感耦合等离子发射光谱仪测定各组钛样品Zn2+的释放浓度；通过抑菌实验及扫描电镜观察接种于复合涂层钛样品表面的牙龈卟啉单胞菌黏附数量和形态。
结果与结论：在Tris缓冲液中Zn2+的释放浓度随着前体溶液中Zn/Ca摩尔比的增加而增加，牙龈卟啉单胞菌在复合涂层钛样品表面生长受到明显的抑制，黏附在材料表面的细菌形态发生改变。结果可见含锌羟基磷灰石二氧化钛复合涂层具有较好的抑菌性能。

关键词: 锌, 钛, 二氧化钛, 羟基磷灰石, 牙龈卟啉单胞菌

Abstract:

BACKGROUND: The effective ways to improve the success rate of titanium implants are to improve the antibacterial properties of titanium implants and reduce the incidence of peri-implantitis.
OBJECTIVE: To investigate the antibacterial properties of the zinc-containing hydroxyapatite (ZnHA)/titania (TiO2) hybrid coating.
METHODS: First, a porous titania coating was produced on pure titanium (Ti) by micro-arc oxidation treatment. And then a ZnHA /TiO2 biological coating was prepared via sol-gel method. The concentration of Zn2+ release of Ti samples in each group was measured by inductively coupled plasma emission spectrometer. The adhesion number and morphologies of Porphyromonas gingivalis W83 implanted on the surface of hybrid coating were characterized by scanning electron microscope and bacteriostasis experiment.
RESULTS AND CONCLUSION: The concentration of Zn2+ release in the Tris buffer was increased with the Zn/Ca molar ratio in precursor solution increased. The growth of Porphyromonas gingivalis on the surface of ZnHA/TiO2 coating was inhibited obviously, and the form of Porphyromonas gingivalis adhered on the surface of coating had changed. These findings suggest that the ZnHA/TiO2 hybrid coatings on titanium implants have good antibacterial property.

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