中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (37): 6987-6992.doi: 10.3969/j.issn.2095-4344.2012.37.029

• 组织构建学术探讨 tissue construction academic discussion • 上一篇    下一篇

骨形态发生蛋白9诱导成骨分化及其在骨科中的应用

杨再清1, 2，孟增东1, 2   

  1. 1昆明医学院附属昆华医院骨科，云南省昆明市 650032
    2云南省第一人民医院骨科，云南省昆明市650032
  • 收稿日期:2011-12-05 修回日期:2012-01-30 出版日期:2012-09-09 发布日期:2012-09-09
  • 通讯作者: 孟增东，副主任医师，硕士生导师，云南省第一人民医院骨科，云南省昆明市 650032 menggu7119@vip.sina.com
  • 作者简介:杨再清★，男，1986年生，云南省龙陵县人，汉族，昆明医学院在读硕士，主要从事骨科基础与临床方面研究。 yzq2010229@126.com

Bone morphogenetic protein 9 induces osteogenic differentiation and its application in orthopedics

Yang Zai-qing1, 2, Meng Zeng-dong1, 2   

  1. 1Department of Orthopedics, Kunhua Hospital, Kunming Medical College, Kunming 650032, Yunnan Province, China
    2Department of Orthopedics, Yunnan First People’s Hospital, Kunming 650032, Yunnan Province, China
  • Received:2011-12-05 Revised:2012-01-30 Online:2012-09-09 Published:2012-09-09
  • Contact: Meng Zeng-dong, Associate chief physician, Master’s supervisor, Department of Orthopedics, Kunhua Hospital, Kunming Medical College, Kunming 650032, Yunnan Province, China; Department of Orthopedics, Yunnan First People’s Hospital, Kunming 650032,Yunnan Province, China menggu7119@vip.sina.com
  • About author:Yang Zai-qing★, Studying for master’s degree, Department of Orthopedics, Kunhua Hospital, Kunming Medical College, Kunming 650032, Yunnan Province, China; Department of Orthopedics, Yunnan First People’s Hospital, Kunming 650032, Yunnan Province, China yzq2010229@126.com

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470

被引次数

2

摘要：

背景：骨形态发生蛋白9是一种强有力的诱导成骨分化的骨形态蛋白，但对它的研究却偏少。
目的：对近年来国内外有关骨形态发生蛋白9诱导成骨分化的研究现状以及其在骨科相关疾病治疗中的应用研究进行综述。
方法：应用计算机检索CNKI 和Pubmed 数据库中2001-01/2011-06 关于骨形态发生蛋白9的文章，以“骨形态蛋白-9；成骨分化；骨缺损；脊柱融合；肿瘤”或“bone morphogenetic protein 9, osteogenic differentiation, bone fracture, spinal fusions, tumor”为关键词进行检索。选择近5 年内关于骨形态发生蛋白9的近期发表或发表在权威杂志的文章。初检得到91 篇文献，根据纳入标准得到34 篇文献并进行系统回顾与综述。
结果与结论：迄今为止，已发现多种生长因子能够促进骨形成，其中，骨形成蛋白是骨组织形成过程中最关键的调节因子。骨形态发生蛋白9属于骨形态发生蛋白家族，不仅能强有力的诱导间充质细胞、前成骨细胞和肌肉细胞等成骨分化，而且在软骨形成中也具有重要作用。其诱导骨形成机制不完全同于传统的骨形态发生蛋白。动物实验证明其还能促进骨折愈合、诱导脊柱融合，调控肿瘤的迁徙。因此，骨形态发生蛋白9在骨科领域中具有潜在的应用前景。

关键词: 骨形态发生蛋白9, 成骨分化, 骨缺损, 脊柱融合, 肿瘤

Abstract:

BACKGROUND: Bone morphogenetic proteins can enhance osteogenic differentiation and bone formation efficiently. Bone morphogenetic protein 9 is one of the most effective Bone morphogenetic proteins to induce osteogenic differentiation. However, it is one of the Bone morphogenetic proteins least studied.
OBJECTIVE: To review the research about bone morphogenetic protein 9 inducing osteogenic differentiation and its application in the treatment of many bony and musculoskeletal disorders at home and abroad in recent years.
METHODS: Bone morphogenetic protein 9 relevant articles from CNKI and PubMed databases from 2001-01 to 2011-06 were retrieved by computer. The articles published during the recent 5 years in the authorized journals related to this subject were collected. The key words were “bone morphogenetic protein 9, osteogenic differentiation, bone fracture, spinal fusions, tumor” in Chinese and English, respectively. There were 91 articles after the initial survey. A total of 34 articles related to BMP were included according to inclusion criteria for review.
RESULTS AND CONCLUSION: So far, several studies have shown that many growth factors can promote bone formation, and bone morphogenetic proteins are probably the most effective regulatory factor in the process of bone tissue formation. Bone morphogenetic protein 9, one of the bone morphogenetic protein family, not only can powerfully induce the osteoblast differentiation of mesenchymal stem cells and muscle cell preosteoblasts, but also play an important role in chondrogenesis, and its mechanism of inducing bone formation does not totally depend on the traditional classical BMP signal pathway. Animal experiments proved that bone morphogenetic proteins can also promote fracture healing, induce spinal fusions and regulate the behavior of tumor. Therefore, bone morphogenetic protein 9 has a bright future in the treatment of skeletal system diseases.

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