中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (36): 6827-6833.doi: 10.3969/j.issn.2095-4344.2012.36.032

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

肺癌肿瘤干细胞表面标志物的研究

于 鸿   

  1. 吉林省肿瘤防治研究所，吉林省长春市 130012
  • 收稿日期:2012-05-15 修回日期:2012-07-10 出版日期:2012-09-02 发布日期:2012-09-02
  • 作者简介:于鸿，女，1969年生，长春市人，汉族，东北师范大学毕业，副研究员，硕士生导师，主要从事肿瘤免疫研究。 yuhongnew@yahoo.com.cn

Surface markers of lung cancer stem cells

Yu Hong   

  1. Tumor Prevention and Cure Institute of Jilin Province, Changchun 130012, Jilin Province, China
  • Received:2012-05-15 Revised:2012-07-10 Online:2012-09-02 Published:2012-09-02
  • About author:Yu Hong, Associate researcher, Master’s supervisor, Tumor Prevention and Cure Institute of Jilin Province, Changchun 130012, Jilin Province, China yuhongnew@yahoo.com.cn

PDF

756

被引次数

2

摘要：

背景：对肿瘤干细胞表面标志物进行检测及跟踪监测研究，可为肿瘤的诊断及生物治疗如免疫治疗等提供重要的帮助。
目的：对肺癌的肿瘤干细胞表面标志物的研究进行文献检索分析，为提高肿瘤的诊断率、改善治疗方法、提高患者的生活质量提供可借鉴的理论依据。
方法：检索SCI数据库2002/2011肺癌肿瘤干细胞表面标志物研究相关文献，采用检索词为“肿瘤干细胞(cancer stem cell)；肺癌(lung cancer)”，共检索110篇文献，选取符合标准的18篇文献进行数据分析。
结果与结论：肺癌是目前世界上发病率和死亡率最高的恶性肿瘤之一，检测肺癌肿瘤干细胞表面标志物CD133可深入研究肿瘤发生、发展及增殖、维持过程，同时CD133可以为肺癌的靶向生物治疗提供相关信息。随着研究的不断深入，肿瘤干细胞表面标志物不仅可以应用于肿瘤的早期诊断，还将应用于肿瘤的生物治疗。

关键词: 肿瘤干细胞, 肺癌, 肺腺癌, 非小细胞肺癌, 靶向治疗, 半乳糖-3, 巢蛋白, CD133, 肿瘤标记物, 肿瘤

Abstract:

BACKGROUND: Detecting, tracking and monitoring the surface markers of cancer stem cells can provide important help for tumor diagnosis and biological treatments, such as immunotherapy.
OBJECTIVE: To review the articles on the surface markers of cancer stem cells in order to provide the reference theoretical basis for tumor diagnosis and improving the treatment methods and life quality.
METHODS: The SCI database was searched for the articles on the surface markers of cancer stem cells published from 2002 to 2011. The key words were “cancer stem cell, lung cancer” in English and Chinese. A total of 110 articles were screened out and finally 18 articles were included to review according to the inclusion criteria.
RESULTS AND CONCLUSION: Lung cancer is one of the malignant tumors with highest morbidity and mortality in the world. Detection of lung cancer stem cell surface marker, CD133, can help to study the occurrence, development and proliferation and maintaining process of tumors, and CD133 can provide relevant information for targeted biological treatments of lung cancer. With the deepening of the study, the cancer stem cell surface markers cannot only be applied for the early diagnosis of the tumor, but also be applied for the biological treatment of the tumor.

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