中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (33): 6215-6222.doi: 10.3969/j.issn.2095-4344.2012.33.027

• 组织构建学术探讨 tissue construction academic discussion • 上一篇    下一篇

碱性成纤维细胞生长因子与小儿烧伤创面的愈合

吴素英   

  1. 湖北民族学院附属医院儿科，湖北省恩施市 445000
  • 收稿日期:2012-03-30 修回日期:2012-07-30 出版日期:2012-08-12 发布日期:2012-08-12
  • 作者简介:吴素英★，女，1965年生，湖北省恩施市人，苗族，2010年武汉大学毕业，硕士，副主任医师，主要从事临床康复方面的研究。 zft211314@qq.com

Basic fibroblast growth factor promotes skin wound healing and pediatric burn wound healing

Wu Su-ying   

  1. Department of Pediatrics, Affiliated Hospital of Hubei University for Nationalities, Enshi 445000, Hubei Province, China
  • Received:2012-03-30 Revised:2012-07-30 Online:2012-08-12 Published:2012-08-12
  • About author:Wu Su-ying★, Master, Associate chief physician, Department of Pediatrics, Affiliated Hospital of Hubei University for Nationalities, Enshi 445000, Hubei Province, China zft211314@qq.com

PDF

337

被引次数

7

摘要：

背景：皮肤创面愈合是一个复杂的病理过程，对于创伤和创伤后感染等引起皮肤难愈合的研究一直是临床创面修复的难题，对于碱性成纤维细胞生长因子促进皮肤创面愈合的基础研究相对较多，临床应用研究较少。
目的：对碱性成纤维细胞生长因子促进皮肤创面愈合研究的文献资料趋势进行多层次分析，探讨在小儿烧伤创面愈合中的应用疗效。
方法：以电子检索方式对CNKI数据库学术期刊2002-01/2011-12收录有关碱性成纤维细胞生长因子促进皮肤创面愈合研究的文献进行分析，采用检索词为“碱性成纤维细胞生长因子；创面愈合”，运用数据库的分析功能和Excel软件图表的功能分析数据特征。
结果与结论：CNKI数据库学术期刊2002/2011收录碱性成纤维细胞生长因子促进皮肤创面愈合研究的文献共228篇，文献数量处于平稳发展趋势。《中国组织工程研究与临床康复》杂志收录的文献数量最多为26篇。解放军第304医院产出的文献最多。碱性成纤维细胞生长因子促进皮肤创面愈合研究文献的基金资助项目有16项，基金资助项目的文献共76篇，以国家重点基础研究发展计划(973)项目和国家自然科学基金资助项目的文献最多。碱性成纤维细胞生长因子在小儿烧伤创面愈合中应用的文献虽然较少，但实验结果均显示治疗效果较好，有促进小儿Ⅱ度烧伤创面愈合的作用，而且无不良反应出现。

关键词: 皮肤创面愈合, 烧伤, 碱性成纤维细胞生长因子, 小儿烧伤, 创面修复, 创伤, 感染, 溃疡

Abstract:

BACKGROUND: Skin wound healing is a complex pathological process, and the research on the difficult healing of skin caused by trauma and post-traumatic infections is the clinical wound healing problem. There are many basic studies on basic fibroblast growth factor promoting skin wound healing, but the clinical studies are rare.
OBJECTIVE: To multi-levelly analyze the effect of basic fibroblast growth factor in promoting skin wound healing and to explore the application efficacy in pediatric burn wound healing.
METHODS: A computer-based search was performed in CNKI database from January 2002 to December 2011 for the literatures on the effect of basic fibroblast growth factor in promoting skin wound healing. The key words were “basic fibroblast growth factor, wound healing” in Chinese. The data characteristics were analyzed by the analysis capabilities of the database and Excel chart function.
RESULTS AND CONCLUSION: There were 228 literatures on the effect of basic fibroblast growth factor in promoting skin wound healing obtained in the CNKI database from 2001 to 2011, and the number of literatures was in the stable development trend. A total of 26 literatures were obtained in the Journal of Clinical Rehabilitative Tissue Engineering Research, and most of the literatures were published by the 304 Hospital of Chinese PLA. The 76 literatures on the effect of basic fibroblast growth factor in promoting skin wound healing were supported by 16 projects. Most of the literatures were supported by the “National Key Basic Research Development Planning Project (973)” and “National Natural Science Foundation of China”. The literatures related to the application of basic fibroblast growth factor in pediatric burn wound healing are rare, but the experimental results show the effect is good, indicating that basic fibroblast growth factor plays an important role in promoting the pediatric Ⅱ degree burn wound healing without adverse reaction.

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