中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (32): 6058-6062.doi: 10.3969/j.issn.2095-4344.2012.32.032

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

泌尿系肿瘤干细胞的研究进展

刘 煜，苟 欣   

  1. 重庆医科大学附属第一医院泌尿外科，重庆市 400016
  • 收稿日期:2011-12-03 修回日期:2011-12-14 出版日期:2012-08-05 发布日期:2012-08-05
  • 通讯作者: 苟欣，教授，主任医师，重庆医科大学附属第一医院泌尿外科，重庆市 400016 gouxincq@163.com
  • 作者简介:刘煜★，男，1985年生，湖南省郴州市人，汉族，重庆医科大学附属第一医院泌尿外科在读硕士，主要从事泌尿系肿瘤的研究。 tommyliuyu@gmail.com

Research progress of cancer stem cells in urologic cancers

Liu Yu, Gou Xin   

  1. Department of Urology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
  • Received:2011-12-03 Revised:2011-12-14 Online:2012-08-05 Published:2012-08-05
  • Contact: Gou Xin, Professor, Chief physician, Department of Urology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
  • About author:Liu Yu★, Studying for master’s degree, Department of Urology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China tommyliuyu@gmail.com

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摘要：

背景：相比而言，泌尿系肿瘤干细胞的研究起步较晚，但也取得了一定的成绩。
目的：综述近年来泌尿系肿瘤干细胞的研究进展。
方法：应用计算机在PubMed数据库中检索1997-01/2011-08有关泌尿系肿瘤干细胞的文献，检索词为“cancer stem cell，urologic cancer”，共检索到文献289篇。经阅读、排除重复及不合标准文献后，最终纳入30篇文献进行分析。
结果与结论：随着人们对肿瘤干细胞研究的不断深入，越来越多的实体瘤干细胞得到鉴定与分离，泌尿系肿瘤干细胞的研究也取得了一定的进展，人们对其生物学特征、自我调控机制及微环境的认识正不断深入，肿瘤干细胞靶向治疗将成为治愈泌尿系肿瘤的新途径。

关键词: 肿瘤干细胞, 泌尿系肿瘤, 研究进展, 前列腺癌, 肾癌, 膀胱癌

Abstract:

BACKGROUND: Although the research about the cancer stem cells from urologic cancers is late, it also makes some achievements.
OBJECTIVE: To review the research progress of urologic cancer stem cells in recent years.
METHODS: Articles related to the research progress of urologic cancer stem cells in PubMed database from January 1997 to August 2011 were retrieved by the computer with the key words “cancer stem cell, urologic cancer”. A total of 289 articles were obtained from the database. The repetitive articles and non-compliant articles were excluded, and finally 30 articles were included for further analysis.
RESULTS AND CONCLUSION: As the in-depth study of cancer stem cells, more and more cancer stem cells have been identified and isolated from kinds of tumors, and cancer stem cells in urologic cancers have acquired some advancement. Their biological characteristics, self-regulatory mechanisms and micro-environment are further understood by researches, and cancer stem cells targeted therapy will become a new way for curing urologic cancers in the future.

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