中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (27): 5118-5125.doi: 10.3969/j.issn.2095-4344.2012.27.034

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

不同来源干细胞移植治疗糖尿病足分析

宋明显   

  1. 塔城市人民医院内一科，新疆维吾尔自治区塔城市 834700
  • 收稿日期:2012-03-30 修回日期:2012-05-30 出版日期:2012-07-01 发布日期:2013-11-01
  • 作者简介:宋明显，女，1973年生，新疆维吾尔自治区塔城市人，锡伯族，1996年新疆医科大学毕业，主治医师，主要从事内分泌专业的研究。 xjyjh@sohu.com

Transplantation of stem cells from different sources for treatment of diabetic foot

Song Ming-xian   

  1. First Department of Internal Medicine, Tacheng People’s Hospital, Tacheng 834700, Xinjiang Uygur Autonomous Region, China
  • Received:2012-03-30 Revised:2012-05-30 Online:2012-07-01 Published:2013-11-01
  • About author:Song Ming-xian, Attending physician, First Department of Internal Medicine, Tacheng People’s Hospital, Tacheng 834700, Xinjiang Uygur Autonomous Region, China xjyjh@sohu.com

PDF

344

被引次数

6

摘要：

背景：糖尿病足患者多伴有肢体远端血管缺血，临床治疗效果一直不是很满意，自体干细胞移植是近几年来兴起的一种安全有效治疗方法。
目的：对干细胞治疗糖尿病足研究的文献资料趋势进行多层次探讨分析。
方法：以电子检索方式对CNKI数据库学术期刊2003/2011收录有关干细胞治疗糖尿病足研究的文献进行分析，采用检索词为“干细胞；糖尿病足”，运用数据库的分析功能和Excel软件图表的功能分析数据特征。
采用自体骨髓干细胞、自体造血干细胞或脐血干细胞等方法移植治疗糖尿病足，将细胞通过肌内注射或血管输注的方式注入下肢缺血部位，治疗后比较肢体疼痛、冷感、皮肤温度、间歇性跛行、溃疡愈合程度和血管造影等结果，判断细胞移植的治疗效果。
结果与结论：在CNKI数据库学术期刊2003/2011收录的文献中，共检索到125篇与干细胞治疗糖尿病足研究相关的文献。文献量呈逐年上升趋势，文献的主要内容显示了糖尿病足、干细胞移植、移植等。干细胞移植以自体细胞来源为主，主要应用骨髓干细胞和造血干细胞两种。通过干细胞移植可以使糖尿病足患者的症状减轻，疼痛得到缓解，下肢血管造影有不同程度的新生侧支血管形成，对改善糖尿病足患者的下肢缺血起到一定作用。

关键词: 糖尿病足, 干细胞, 自体, 骨髓, 造血, 骨髓干细胞, 造血干细胞, 自体干细胞, 文献计量

Abstract:

BACKGROUND: Diabetic foot patients often exhibit limb distal ischemia and the clinical outcomes are not very satisfactory. Autologous stem cells transplantation is a safe and effective treatment method in recent years.
OBJECTIVE: To explore the literature trends of stem cells transplantation for the treatment of diabetic foot.
METHODS: The CNKI database from January 2003 to December 2011 was searched for the literatures related to stem cells for the treatment of diabetic foot. The key words were “stem cells, diabetic foot” and the characteristics of the data were analyzed by analysis capabilities of the database and the chart function of Excel software. The autologous bone marrow stem cells, autologous hematopoietic stem cells or umbilical cord blood stem cell transplantation were used for the treatment of diabetic foot; the cells were injected into the lower limb ischemia site through intramuscular injection or vascular infusion. The physical pain, cold sensation, skin temperature, intermittent claudication, ulcer healing degree and angiographic results were compared after treatment, and the effect of cells transplantation was assessed.
RESULTS AND CONCLUSION: Among the literatures included in the CNKI database from 2003 to 2011, a total of 125 literatures related to the stem cells for the treatment of diabetic foot were screened out. The amount of the literatures showed an increasing trend, and the main content of the literatures containing the diabetic foot, stem cell transplantation and transplantation. Stem cells for the transplantation mainly include autologous cells, including bone marrow stem cells and hematopoietic stem cells. Stem cells transplantation can alleviate the symptoms of diabetic foot and release the pain, and during the transplantation, lower limb angiography shows varying degrees of neonatal collateral blood vessel formation which plays an important role in improving the lower limb ischemia of diabetic foot patients.

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