中国组织工程研究 ›› 2019, Vol. 23 ›› Issue (13): 2101-2106.doi: 10.3969/j.issn.2095-4344.1654

• 干细胞综述 stem cell review • 上一篇    下一篇

Eph/ephrin信号通路与神经干细胞的增殖和分化

刘 正1,2,邵子玮1,袁文华1,2,沈 伟1,2,冯晓飞1,2,周海宇1   

  1. 1兰州大学第二医院骨科,甘肃省兰州市 730030;2甘肃省骨关节疾病研究重点实验室,甘肃省兰州市 730030
  • 修回日期:2018-12-22 出版日期:2019-05-08 发布日期:2019-05-08
  • 通讯作者: 周海宇,博士,兰州大学第二医院骨科,甘肃省兰州市 730030
  • 作者简介:刘正,男,1993年生,重庆市人,兰州大学在读硕士,主要从事脊柱脊髓的基础与临床研究。
  • 基金资助:

    甘肃省自然科学基金项目(17JR5RA189),项目负责人:周海宇

Eph/ephrin signaling pathway and neural stem cell proliferation and differentiation

Liu Zheng1, 2, Shao Ziwei1, Yuan Wenhua1, 2, Shen Wei1, 2, Feng Xiaofei1, 2, Zhou Haiyu1   

  1. 1Department of Orthopedics, Second Hospital of Lanzhou University, Lanzhou 730030, Gansu Province, China; 2Key Laboratory of Bone and Joint Diseases of Gansu Province, Lanzhou 730030, Gansu Province, China
  • Revised:2018-12-22 Online:2019-05-08 Published:2019-05-08
  • Contact: Zhou Haiyu, MD, Department of Orthopedics, Second Hospital of Lanzhou University, Lanzhou 730030, Gansu Province, China
  • About author:Liu Zheng, Master candidate, Department of Orthopedics, Second Hospital of Lanzhou University, Lanzhou 730030, Gansu Province, China; Key Laboratory of Bone and Joint Diseases of Gansu Province, Lanzhou 730030, Gansu Province, China
  • Supported by:

    the Natural Science Foundation of Gansu Province, No. 17JR5RA189 (to ZHY)

摘要:

文章快速阅读:

文题释义:
Eph/ephrin:
Eph受体酪氨酸激酶家族在发育过程、组织稳态和各种疾病中起重要作用。与邻近细胞表面ephrin配体的相互作用触发Eph受体激酶依赖性信号传导。Ephrin配体还可以传输信号,从而实现双向的依赖于细胞接触的通信。鉴于它们涉及从神经性疾病到癌症等许多病理过程,Eph受体和ephrin配体越来越被认为是有吸引力的治疗靶标,并且正在探索各种策略来调节它们的表达和功能。
神经干细胞:是指存在于神经系统中,具有自我更新能力,可以分化为神经元、星形胶质细胞和少突胶质细胞的细胞群。神经干细胞的增殖、分化受诸多因素影响,如何让神经干细胞在复杂的信号网络调控中实现有序的增殖、分化,目前还未完全清楚。尽管有大量关于干细胞治疗的研究,但只有特异性参与神经干细胞行为的靶基因的报道是不够的。因此,迫切需要探究调节神经干细胞增殖和分化的分子机制。

 

摘要
背景:
研究表明,移植入宿主体内的神经干细胞可分化为神经元或神经胶质细胞。Eph/Ephrin信号通路与神经干细胞的增殖分化密切相关。通过调节Eph/Ephrin信号通路可控制神经干细胞的定向增殖分化。
目的:对神经干细胞增殖、分化与Eph/Ephrin信号通路的关系进行综述。
方法:应用计算机检索 2000年1月至2018年11月Medline 数据库、Ovid 数据库、CNKI数据库、万方数据库,中文检索词为“Eph/ephrin信号通路,神经干细胞,分化,增殖”,英文检索词为“Eph/ephrin signaling pathway,neural stem cells,differentiation,proliferation”。纳入与神经干细胞增殖、分化及Eph/Ephrin信号系统相关的文献,排除重复性研究,保留51篇文献进行综述。
结果与结论:神经干细胞是一类具有自我更新和多向分化潜能的细胞,能分化形成中枢神经系统几乎所有类型的细胞。Eph/Ephrin信号通路在神经干细胞的增殖分化中起重要作用。文章从神经干细胞、Eph/Ephrin信号通路、Eph/Ephrin信号通路与神经干细胞的增殖分化等方面分别进行了叙述。然而,Eph/Ephrin信号通路控制神经干细胞分化的具体机制还不是很清楚。


中国组织工程研究杂志出版内容重点:干细胞;骨髓干细胞;造血干细胞;脂肪干细胞;肿瘤干细胞;胚胎干细胞;脐带脐血干细胞;干细胞诱导;干细胞分化;组织工程
ORCID:
0000-0001-6777-2716(刘正)

关键词: 神经干细胞, Eph/ephrin信号通路, 神经干细胞分化, 神经干细胞增殖, 神经元, 神经胶质细胞, 甘肃省自然科学基金

Abstract:

BACKGROUND: Studies have shown that neural stem cells transplanted into a host can differentiate into neurons or glial cells. Eph/Ephrin signaling pathway is closely related to the proliferation and differentiation of neural stem cells. Directed proliferation and differentiation of neural stem cells can be controlled by modulating the Eph/Ephrin signaling pathway.
OBJECTIVE: To review the neural stem cell proliferation and differentiation and its relationship with Eph/Ephrin signaling pathway.
METHODS: A computer search of Medline, Ovid, CNKI, EBSCO databases (2000-01/2018-11) was performed, and the search terms were “Eph/ephrin signaling pathway, neural stem cells, differentiation, proliferation” in English and Chinese, respectively. The literatures related to neural stem cell proliferation and differentiation and Eph/Ephrin signaling system were included, and repetitive studies were excluded. Finally 51 literatures were retained for review.
RESULTS AND CONCLUSION: Neural stem cells are a class of cells with self-renewal and multi-directional differentiation potential that can differentiate into almost all types of cells in the central nervous system. The Eph/Ephrin signaling pathway plays a vital role in the proliferation and differentiation of neural stem cells. This article reviews the neural stem cells, Eph/Ephrin signaling pathway, and the relationship between Eph/Ephrin signaling pathway and proliferation and differentiation of neural stem cells. However, the specific mechanism by which the Eph/Ephrin signaling pathway controls neural stem cell differentiation is not well understood.

Key words: Neural Stem Cells, Receptors, Eph Family, Ephrins, Tissue Engineering

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