中国组织工程研究

中国组织工程研究 ›› 2019, Vol. 23 ›› Issue (35): 5703-5709.doi: 10.3969/j.issn.2095-4344.1489

• 组织构建综述 tissue construction review • 上一篇    下一篇

低氧环境下蛋白质糖基化参与免疫反应机制的研究进展

陈  垚，赵  敏，李文华   

  1. (西藏民族大学医学部，陕西省咸阳市  712082)
  • 收稿日期:2019-04-13 出版日期:2019-12-18 发布日期:2019-12-18
  • 通讯作者: 李文华，硕士，教授，西藏民族大学医学部，陕西省咸阳市 712082
  • 作者简介:陈垚，男，1992年生，陕西省商南县人，汉族，西藏民族大学医学部在读硕士，主要从事病理解剖与病理生理学的研究。
  • 基金资助:

    国家自然科学基金(81760332)，项目负责人：李文华；西藏科技厅自然科学基金重点项目(XZ2017ZRG-67(Z)，项目负责人：李文华；西藏科技厅自然科学项目(XZ-2018ZRG-71)；西藏民族大学青年学人培育计划项目(18MDX02)

Research progress of mechanism of protein glycosylation in the immune reaction under hypoxia

Chen Yao, Zhao Min, Li Wenhua   

  1.  (Department of Medicine, Xizang Minzu University, Xianyang 712082, Shaanxi Province, China)
  • Received:2019-04-13 Online:2019-12-18 Published:2019-12-18
  • Contact: Li Wenhua, Master, Professor, Department of Medicine, Xizang Minzu University, Xianyang 712082, Shaanxi Province, China
  • About author:Chen Yao, Master candidate, Department of Medicine, Xizang Minzu University, Xianyang 712082, Shaanxi Province, China
  • Supported by:

    the National Natural Science Foundation of China, No. 81760332 (to LWH); the Major Project of Natural Science Foundation of Science and Technology Department of Tibet, No. XZ2017ZRG-67(Z) (to LWH); the Natural Science Project of Science and Technology Department of Tibet, No. XZ-2018ZRG-71; the Young Talent Training Program of Xizang Minzu University, No. 18MDX02

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摘要：

文章快速阅读：

文题释义：
糖基化：是在酶的控制下，蛋白质或脂质附加上糖类的过程，发生于内质网。在糖基转移酶作用下将糖转移至蛋白质，和蛋白质上的氨基酸残基形成糖苷键。蛋白质经过糖基化作用，形成糖蛋白。糖基化是对蛋白重要的修饰作用，有调节蛋白质功能作用。
免疫反应：是指机体对于异己成分或者变异的自体成分做出的防御反应。免疫反应可分为非特异性免疫反应和特异性免疫反应。非特异性免疫构成人体防卫功能的第一道防线，并协同和参与特异性免疫反应。特异性免疫反应可表现为正常的生理反应、异常的病理反应以及免疫耐受。按介导效应反应免疫介质的不同，特异性免疫反应又可分为T细胞介导的细胞免疫反应和B细胞介导的体液免疫反应。
摘要
背景：糖基化作为蛋白质重要的翻译后修饰之一而广泛的存在与生物体内，其合成过程显著受到细胞所处环境的影响。
目的：通过对细菌、病毒及肿瘤所形成的低氧微环境下蛋白质糖基化参与免疫反应的研究做一总结，以探讨高原低氧时蛋白质糖基化参与免疫反应的机制，
方法：以“protein glycosylation，immune reaction，hypoxia”为检索词，检索PubMed数据1988年1月至2019年1月与细菌、病毒及肿瘤所致的糖基化对免疫反应影响相关的文献。按照纳入排除标准，对最终选入的61篇文献进行探讨。
结果与结论：近年研究发现，低氧可导致机体或细胞的糖基化过程改变，并可导致蛋白的生物学活性发生变化。蛋白的糖基化修饰在病毒的传染、病毒颗粒的形成及其发生免疫逃避的过程中都扮演着重要角色。在肿瘤细胞的进展过程中，由于氧缺乏及糖摄取的增加导致了糖酵解的发生，而血葡萄糖浓度的升高诱发了蛋白非酶催化的糖基化或糖化，并导致了晚期糖基化产物的蓄积。高原环境作为首要的环境因素缺氧是机体发生损伤的基础，可导致一系列疾病的发生，而在此之中是否涉及糖基化的改变还有待进一步证实。

关键词: 蛋白质糖基化, 免疫反应, 缺氧, 细菌, 病毒, 肿瘤

Abstract:

BACKGROUND: As one of the important post-translation modifications, the protein glycosylation inhere in the biosome extensively, and its synthetize process is influenced by the surroundings of the cells.
OBJECTIVE: To summarize the study on the protein glycosylation with the immune reaction under hypoxia developed in the bacteria, virus and tumors infecting, so as to discuss the mechanism of the protein glycosylation with the immune reaction in the plateau hypoxia.
METHODS: PubMed database between January 1988 and January 2019 was retrieved for relevant articles on the effect of glycosylation induced by bacteria, virus and tumors. The keywords were “protein glycosylation, immune reaction, hypoxia”. Finally 61 articles eligible for inclusion and exclusion criteria were included for result analysis.
RESULTS AND CONCLUSION: In recent years, hypoxia has been shown to cause the changes of glycosylation in organism or cells, and moreover can change the biologic activity of protein. Protein glycosylation modification plays an important role in the virus infection, virus particle formation and immune escape. Lack of oxygen and increased sugar intake lead to glycolysis in the progress of tumor cells, and elevated blood glucose levels induce non-enzymatic glycosylation or saccharification, further resulting in the accumulation of advanced glycosylation product. Plateau environment of oxygen is the basis of airframe damage, can lead to a series of diseases, and whether glycosylation change is involved needs to be investigated in depth.

Key words: protein glycosylation, immune reaction, hypoxia, bacteria, virus, tumor

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