中国组织工程研究

中国组织工程研究 ›› 2019, Vol. 23 ›› Issue (34): 5570-5576.doi: 10.3969/j.issn.2095-4344.1448

• 生物材料综述 biomaterial review • 上一篇    

低氧环境下蛋白质乙酰化修饰研究学术进展与存在的问题

赵  敏，陈  垚，李旭光，李文华
  

  1. 西藏民族大学医学部，陕西省咸阳市  712082
  • 收稿日期:2019-06-15 出版日期:2019-12-08 发布日期:2019-12-08
  • 通讯作者: 李文华，医学学士，教授，西藏民族大学医学部，陕西省咸阳市 712082
  • 作者简介:赵敏，男，1994年生，安徽省巢湖市人，汉族，西藏民族大学医学部在读硕士，主要从事病理学与病理生理学研究。
  • 基金资助:

    2017国家自然科学基金资助项目(81760332)，项目负责人：李文华；2017西藏科技厅自然科学基金重点项目(XZ2017ZRG-67(Z))，项目参与者：李文华；2018西藏科技厅自然科学项目(XZ-2018ZRG-71)，项目参与者：李文华；2018西藏民族大学青年学人培育计划项目(18MDX02)，项目参与者：李文华

Protein acetylation in hypoxic environment: research advance and the existing problems

Zhao Min, Chen Yao, Li Xuguang, Li Wenhua
  

  1. School of Medicine, Xizang Minzu University, Xianyang 712082, Shaanxi Province, China
  • Received:2019-06-15 Online:2019-12-08 Published:2019-12-08
  • Contact: Li Wenhua, Professor, School of Medicine, Xizang Minzu University, Xianyang 712082, Shaanxi Province, China
  • About author:Zhao Min, Master candidate, School of Medicine, Xizang Minzu University, Xianyang 712082, Shaanxi Province, China
  • Supported by:

    2017 National Natural Science Foundation of China, No. 81760332 (project leader: LWH); 2017 Xizang Science and Technology Department Natural Science Fund (Key Project), No. XZ2017ZRG-67(Z) (project participant: LWH); 2018 Xizang Science and Technology Department Natural Science Project, No. XZ-2018ZRG-71 (project participant: LWH); 2018 Xizang Minzu University Youth Scholars Program, No. 18MDX02 (project participant: LWH)

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摘要：

文章快速阅读：

 

文题释义：
蛋白质组学：蛋白质组的研究不仅能为生命活动规律提供物质基础，也能为众多种疾病机制的阐明及攻克提供理论根据和解决途径。通过对正常个体及病理个体间的蛋白质组比较分析，可以找到某些“疾病特异性的蛋白质分子”，它们可成为新药物设计的分子靶点，或者也会为疾病的早期诊断提供分子标志，是生命科学进入后基因时代的特征。
蛋白质乙酰化：蛋白质中的赖氨酸乙酰化修饰调控蛋白质的多种性质，包括DNA-蛋白质相互作用、亚细胞定位、转录活性、蛋白质稳定性等。除了这些重要的生物学功能外，赖氨酸乙酰化蛋白质及其调控酶与衰老和几种重大疾病(如癌症、神经变形紊乱、心血管疾病等)紧密相联。
 
 
背景：近年研究发现蛋白质乙酰化在应激反应中也扮演着重要角色，受去乙酰化酶和乙酰基转移酶的调控，已成为蛋白质领域的研究热点。
目的：总结低氧环境中机体蛋白质乙酰化的改变。
方法：应用计算机检索2000至2019年PubMed、Medline数据库，以及2011至2017年中国知网、万方数据库发表的相关文献，检索关键词为“Hypoxia，acetylation of proteins，stress response；低氧，蛋白质乙酰化，应激反应”。
结果与结论：蛋白质乙酰化在细胞内的诸多进程中发挥着重要作用，如转录、染色质重塑、蛋白质的合成和降解、新陈代谢等。低氧环境下，蛋白质乙酰化已涉及到众多领域当中，与多种癌症、心脑血管疾病及一些表观遗传学疾病等疾病有关。蛋白质乙酰化虽然能促进肿瘤细胞的转移，但也能对肿瘤治疗带来很大的帮助，并且从这些研究中可以发现蛋白质乙酰化必定会给肿瘤提供新的治疗方法。但目前的研究还是有所不足，需要在此基础上进行更加深入的研究。

关键词: 蛋白质的乙酰化, 低氧, 应激反应, 线粒体功能, DNA, 肿瘤, 心血管疾病, 糖尿病

Abstract:

BACKGROUND: Recent studies have found that protein acetylation plays an important role in stress response, which is regulated by deacetylase and acetyltransferase, and has become a research hotspot in the field of protein.
OBJECTIVE: To summarize the change of protein acetylation in hypoxic environment.
METHODS: English literatures published during 2000-2019 were retrieved from Pubmed and Medline. Chinese literatures published during 2001-2017 were retrieved from CNKI and Wanfang databases. Search terms were “Hypoxia, acetylation of proteins, stress response” in English and Chinese respectively.
RESULTS AND CONCLUSION: Protein acetylation plays an important role in many cellular processes, such as transcription, chromatin remodeling, protein synthesis and degradation, and metabolism. In hypoxic environment, protein acetylation has been involved in many fields, which are related to many diseases such as cancer, cardiovascular and cerebrovascular diseases, and some epigenetic diseases. Although protein acetylation can promote the metastasis of cancer cells, it can also bring great help to cancer treatment. From these studies, it can be found that protein acetylation will certainly provide a new treatment for cancer. However, there are still some deficiencies in the current research, and more in-depth research is needed on this basis.  

Key words: protein acetylation, hypoxia, stress response, mitochondrial function, DNA, cancer, cardiovascular disease, diabetes mellitus

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