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文题释义：
慢性根尖周炎：是指根尖周围组织包括牙骨质、牙槽骨和牙周膜，由于多种细菌等病原微生物的相互作用形成的慢性感染性疾病。慢性根尖周炎大多是牙髓坏死的结局，也可因严重的牙周袋内的感染物质侵袭造成。慢性根尖周炎最终会导致牙槽骨的破坏吸收，甚至造成牙齿脱落。
RANKL：全称receptor activator of NF-κBligand，简称RANKL，是核因子κB受体活化因子配体，TNF家族中的一员，为Ⅱ型跨膜蛋白，在T、B 淋巴细胞、单核-巨噬细胞等多种免疫细胞均有表达，RANKL可与破骨前体细胞的细胞膜表面的RANK受体结合，激活其下游的信号分子，诱导破骨细胞，发挥调节破骨细胞分化和成熟的功能。
.jpg)
文题释义：
慢性根尖周炎：是指根尖周围组织包括牙骨质、牙槽骨和牙周膜，由于多种细菌等病原微生物的相互作用形成的慢性感染性疾病。慢性根尖周炎大多是牙髓坏死的结局，也可因严重的牙周袋内的感染物质侵袭造成。慢性根尖周炎最终会导致牙槽骨的破坏吸收，甚至造成牙齿脱落。
RANKL：全称receptor activator of NF-κBligand，简称RANKL，是核因子κB受体活化因子配体，TNF家族中的一员，为Ⅱ型跨膜蛋白，在T、B 淋巴细胞、单核-巨噬细胞等多种免疫细胞均有表达，RANKL可与破骨前体细胞的细胞膜表面的RANK受体结合，激活其下游的信号分子，诱导破骨细胞，发挥调节破骨细胞分化和成熟的功能。