中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (25): 4701-4705.doi: 10.3969/j.issn.1673-8225.2012.25.029

• 生物材料综述 biomaterial review • 上一篇    下一篇

抗肿瘤药物载体的主动靶向策略

尤左祥1, 2，杨亲正1，岳占国2，马光辉2，魏 炜2   

  1. 1山东轻工业学院食品与生物工程学院，山东省济南市 250353；
    2中国科学院过程工程研究所生化工程国家重点实验室，北京市 100190
  • 收稿日期:2011-10-09 修回日期:2011-11-18 出版日期:2012-06-17 发布日期:2013-11-04
  • 通讯作者: 杨亲正，博士，副教授，硕士生导师，山东轻工业学院食品与生物工程学院，山东省济南市250353 yangqinzheng@sina.com 魏炜，博士，助理研究员，中国科学院过程工程研究所生化工程国家重点实验室，北京100190 weiwei@ home.ipe.ac.cn
  • 作者简介:尤左祥★，男，1985年生，山东省莒南县人，汉族，山东轻工业学院在读硕士，主要从事生物医学载药纳米材料研究。 xiang85518@ 126.com

10.3969/j.issn.1673-8225.2012.25.029

You Zuo-xiang1, 2, Yang Qin-zheng1, Yue Zhan-guo2, Ma Guang-hui2, Wei Wei2   

  1. 1Department of Food and Bioengineering, Shandong Polytechnic University, Jinan 250353, Shandong Province, China;
    2National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China
  • Received:2011-10-09 Revised:2011-11-18 Online:2012-06-17 Published:2013-11-04
  • Contact: Yang Qin-zheng, Doctor, Associate professor, Master’s supervisor, Department of Food and Bioengineering, Shandong Polytechnic University, Jinan 250353, Shandong Province, China yangqinzheng@ sina.com Wei Wei, Doctor, Assistant researcher, National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China weiwei@ home.ipe.ac.cn
  • About author:You Zuo-xiang★, Studying for master’s degree, Department of Food and Bioengineering, Shandong Polytechnic University, Jinan 250353, Shandong Province, China; National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China xiang85518@ 126.com

PDF

850

被引次数

10

摘要：

背景：抗肿瘤药物给药后，在机体内往往非特异性分布，毒副作用大，生物利用度低，具有主动靶向功能的药物载体可成功解决这一问题。
目的：综合论述了近年来国内外制备主动靶向药物载体应用于抗肿瘤药物输送的最新研究，归纳总结出药物载体的各类主动靶向策略。
方法：应用计算机检索平台ISI Web of Knowledge检索2004/2011各英文数据库，检索词采用与抗肿瘤药物载体靶向给药密切相关的关键词，如“tumor，drug carrier，active targeting”等，共检索到文献58篇，最终纳入符合标注的文献26篇。
结果与结论：主动靶向策略是设计抗肿瘤药物载体时首先需要考虑也是最为重要的环节，它决定了药物载体实际的药物输送效果以及药物的生物利用度。具有主动靶向策略的药物载体可携带抗肿瘤药物到达肿瘤部位，显著减少机体内其他部位药物的非特异性分布，从而降低其毒副作用，提高生物利用度。

关键词: 肿瘤, 药物载体, 靶向策略, 主动靶向, 综述文献

Abstract:

BACKGROUND: The non-specific distribution of anticancer drugs in vivo may cause serious side effects and low bioavailability. Drug carriers with the active targeting abilities can solve these problems.
OBJECTIVE: To review the recent studies on carrier preparation for anticancer drug delivery and summarize different types of active targeting strategies for drug carrier.
METHODS: A computer-based online search was performed for articles published from 2004 to 2011 in Web of Knowledge database with the English key words that closely related to various active targeting strategies, such as “tumor, drug carrier, active targeting”. Totally 58 articles were retrieved, and finally 26 of them met the requirement.
RESULTS AND CONCLUSION: Active targeting strategy is the first problem need to consider and the most important part in designing anticancer drug carriers. It contributes to the actual effect of drug delivery and bioavailability of drug. Drug carriers with various active targeting abilities can carry antitumor drugs to tumor sites and significantly reduced the non-specific distribution of drugs in vivo in order to decrease the side effects and enhanced bioavailability.

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