中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (23): 4323-4328.doi: 10.3969/j.issn.1673-8225.2012.23.028

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

自体造血干细胞移植治疗淋巴瘤的进展

郭毅刚，冯雪连，刘 林   

  1. 重庆医科大学附属第一医院血液内科，重庆市 400016
  • 收稿日期:2011-09-05 修回日期:2011-09-05 出版日期:2012-06-03 发布日期:2013-11-06
  • 通讯作者: 刘林，博士，硕士生导师，主任，教授，重庆医科大学附属第一医院血液内科，重庆市 400016 Liul7776@yahoo.com.cn
  • 作者简介:郭毅刚★，男，1985年生，湖北省十堰市人，汉族，重庆医科大学在读硕士，主要从事血液病的临床诊断及治疗，以及干细胞移植患者的管理工作。 youasme@yeah.net

Progress of autologous hematopoietic stem cells transplantation in the treatment of lymphoma

Guo Yi-gang, Feng Xue-lian, Liu Lin   

  1. Department of Hematology, First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
  • Received:2011-09-05 Revised:2011-09-05 Online:2012-06-03 Published:2013-11-06
  • Contact: Liu Lin, M.D., Master’s supervisor, Professor, Department of Hematology, First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, Sichuan Province, China Liul7776@yahoo.com.cn
  • About author:Guo Yi-gang★, Studying for master’s degree, Department of Hematology, First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China youasme@yeah.net

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651

被引次数

22

摘要：

背景：自体造血干细胞移植是治疗淋巴瘤的积极有效方案。
目的：综述自体造血干细胞移植治疗淋巴瘤的研究进展。
方法：应用计算机检索2000-01/2011-08 PudMed、CNKI数据库、万方数据库、维普数据库及中华医学会数字期刊数据库及Google网络数据库自体造血干细胞移植治疗淋巴瘤的相关文章，检索词为“autologous hematopoietic stem cell transplantation，lymphoma，自体造血干细胞移植，淋巴瘤”。共检索到文献371篇，最终纳入符合标准的文献31篇。
结果与结论：自体造血干细胞移植自20世纪80年代兴起以来，成千上万的淋巴瘤患者获益。其移植前的治疗从最初以单纯大剂量放化疗作为预处理方案发展到联合利妥昔单抗甚至联合同位素标记的单抗作为预处理方案；利妥昔单抗也从仅作为预处理前的净化用药发展到利妥昔单抗在移植前后长期序贯用药。但是无论移植前后的治疗如何进展改变，自体造血干细胞移植为患者备份造血系统，促进患者在接受大剂量的预处理后造血系统功能快速恢复的本质作用始终没有发生改变。随着研究的进一步发展，自体造血干细胞移植将成为淋巴瘤治疗的重要方案。

关键词: 自体造血干细胞移植, 淋巴瘤, 预处理, 放射免疫, 过继免疫, 综述文献, 干细胞

Abstract:

BACKGROUND: Autologous hematopoietic stem cells transplantation is an effective scheme for treatment of lymphoma.
OBJECTIVE: To summarize the progress of autologous hematopoietic stem cells transplantation in the treatment of lymphoma
METHODS: We retrieved PubMed database, CNKI database, Wanfang database, Vip database, digital journals of Chinese Medical Association and Google network database for articles published from January 1990 to February 2011, which was about autologous hematopoietic stem cells transplantation in the treatment of lymphoma. The key words were “autologous hematopoietic stem cells transplantation, lymphoma”. A total of 371 articles were retrieved and 31 articles were included according to the inclusion criteria.
RESULTS AND CONCLUSION: Hundreds of thousands patients with lymphoma have been cured since autologous hematopoietic stem cells transplantation was developed in 1980s. Before transplantation, the pretreatment scheme from simple high-dose chemotherapy regimen at first evolved into combined with rituximab and isotope-labeled monoclonal antibody; the rituximab developed from a purification medication before pretreatment to an important medication that was used before and after autologous hematopoietic stem cells transplantation for a long time. However, autologous hematopoietic stem cells transplantation, as a backup of hematopoietic system for patients promotes hemopoietic system recovery quickly after pretreatment. With further development, autologous hematopoietic stem cells transplantation will become the important scheme of lymphoma treatments.

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