中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (23): 4310-4315.doi: 10.3969/j.issn.1673-8225.2012.23.026

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

脂肪干细胞及其移植治疗脑缺血的研究与应用

蒋 为1，梁国标2，刘民培3   

  1. 1大连医科大学，辽宁省大连市 116027；解放军沈阳军区总医院，2神经外科，3全军神经医学研究所实验室，辽宁省沈阳市 110016
  • 收稿日期:2011-09-01 修回日期:2011-10-18 出版日期:2012-06-03 发布日期:2013-11-06
  • 通讯作者: 梁国标，教授，主任医师，硕士生导师，解放军沈阳军区总医院神经外科，辽宁省沈阳市110016 liangguobiao6708@163.com
  • 作者简介:蒋为★，男，1980年生，辽宁省沈阳市人，汉族，大连医科大学在读硕士，主要从事干细胞在脑血管等疾病治疗中的研究。 doctorjw@163.com

Development of adipose-derived stem cells and their transplantation for treatment of cerebral ischemia

Jiang Wei1, Liang Guo-biao2, Liu Min-pei3   

  1. 1Dalian Medical University, Dalian 116027, Liaoning Province, China;
    2Department of Neurosurgery, the General Hospital of Shenyang Military Region, Shenyang 110016, Liaoning Province, China;
    3Military Institute of Neurological Medicine of Chinese PLA, Shenyang 110016, Liaoning Province, China
  • Received:2011-09-01 Revised:2011-10-18 Online:2012-06-03 Published:2013-11-06
  • Contact: Liang Guo-biao, Master’s supervisor, Professor, Chief physician, Department of Neurosurgery, the General Hospital of Shenyang Military Region, Shenyang 110016, Liaoning Province, China liangguobiao6708@163.com
  • About author:Jiang Wei★, Studying for master’s degree, Dalian Medical University, Dalian 116027, Liaoning Province, China doctorjw@163.com

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摘要：

背景：研究表明，脂肪干细胞移植治疗动物脑缺血可改善其神经功能。
目的：复习相关文献就脂肪干细胞的生物学特性、分化能力及其在脑缺血疾病中的应用研究作一综述。
方法：应用计算机检索CNKI，PubMed数据库中2005/2010关于“脂肪干细胞及其移植治疗脑缺血的研究进展”的文章，以“脂肪干细胞，移植治疗，脑缺血”为检索词进行检索，选择内容为同脂肪干细胞及其在脑缺血治疗中的应用研究相关，同一领域文章则选择近3~5年内发表的文章或权威文章。初检到的中英文共152篇，根据纳入标准选择38篇进行综述。
结果与结论：脂肪干细胞其具有取材方便、来源丰富、扩增迅速、无致瘤性、低免疫原性、无伦理约束等多种优势，临床前期实验已经证实，脂肪干细胞移植可改善神经功能紊乱，缩小脑梗死区域，可促进血管新生，改善病灶区血供，并表达神经特异性标志物。实验中脂肪干细胞的移植途径及时间都不同，实验结果都证实了神经功能的改善，但其具体的治疗机制尚不清楚，仍需要扩大对脂肪干细胞移植治疗脑缺血的临床前期研究数量，进一步完善其治疗机制。

关键词: 脂肪干细胞, 细胞分化, 移植治疗, 脑缺血, 综述文献, 干细胞

Abstract:

BACKGROUND: Studies show that transplantation of adipose-derived stem cells (ADSCs) can improve the neurological functions of animals in treatment of cerebral ischemia.
OBJECTIVE: To summarize the literatures on the biological characteristics, differentiation, and applications in ischemic diseases of ADSCs.
METHODS: A computer-based online search of literatures published from January 2005 to December 2010 related to the development of adipose-derived stem cells and their transplantation for treatment of cerebral ischemia was performed in CNKI database and PubMed database using the key words of “adipose-derived stem cells, therapy of transplant, cerebral ischemia”. The documents associated with the development of adipose-derived stem cells and their transplantation for treatment of cerebral ischemia were selected, and those published in 3-5 years or in authoritative journals were preferred in the same field. Totally 152 articles in English and Chinese were obtained in initial retrieval, and 38 of them were chosen to summarize based on inclusion criteria.
RESULTS AND CONCLUSION: ADSCs have many advantages including easy-to-obtain, rich resources, rapid expansion, non-tumorigenesis, low immunogenicity, and non-ethical constraints. Preclinical experiments have demonstrated that transplantation of ADSCs can improve the neurological functions, reduce the region of small cerebral infarction, promote angiogenesis, and express neuron-specific markers. The improvement of neurological functions was proved in experiments with different ways and times of ADSCs transplantation, but the mechanism is still unclear. The treatment of ischemic disease by ADSCs transplantation needs more research to consummate the mechanism.

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