中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (23): 4301-4305.doi: 10.3969/j.issn.1673-8225.2012.23.024

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

干细胞移植治疗阿尔茨海默病的研究现状及展望

于程程1，2，3，张 斌2，3，陈 虎2，3   

  1. 1解放军总医院，北京市 100853；
    2解放军军事医学科学院附属医院造血干细胞移植，北京市100071；
    3解放军军事医学科学院细胞与基因治疗中心，北京市 100071
  • 收稿日期:2011-09-01 修回日期:2011-10-20 出版日期:2012-06-03 发布日期:2013-11-06
  • 通讯作者: 陈虎，博士，主任医师，教授，解放军军事医学科学院附属医院造血干细胞移植科，北京市100071 chenhu217@yahoo.com.cn 并列通讯作者：张斌，博士，副研究员，副教授。解放军军事医学科学院附属医院造血干细胞移植科，北京市100071 zb307ctc@163.com
  • 作者简介:于程程★，女，1986年生，解放军军事医学科学院在读硕士，主要从事造血干细胞移植研究。 yucheng_hmu@126.com
  • 基金资助:

    国家“十二五”863计划主题项目(2011AA020114)

Research and prospects of stem cells transplantation for the treatment of Alzheimer’s disease

Yu Cheng-cheng1, 2, 3, Zhang Bin2, 3, Chen Hu2, 3   

  1. 1Chinese PLA General Hospital, Beijing 100853, China;
    2Department of Hematopoietic Stem Cell Transplantation, Affiliated Hospital to Academy of Military Medical Sciences, Beijing 100071, China;
    3Cell and Gene Therapy Center of Academy of Military Medical Sciences, Beijing 100071, China
  • Received:2011-09-01 Revised:2011-10-20 Online:2012-06-03 Published:2013-11-06
  • Contact: Chen Hu, M.D., Chief physician, Professor, Zhang Bin, M.D., Associate researcher, Associate professor, Department of Hematopoietic Stem Cell Transplantation, Affiliated Hospital to Academy of Military Medical Sciences, Beijing 100071, China; Cell and Gene Therapy Center of Academy of Military Medical Sciences, Beijing 100071, China chenhu217@yahoo.com.cn; zb307ctc@163.com
  • About author:Chinese PLA General Hospital and Department of Hematopoietic Stem Cell Transplantation, Affiliated Hospital to Academy of Military Medical Sciences were considered as co-first institutional affiliation.

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440

被引次数

7

摘要：

背景：神经干细胞、骨髓来源的间充质干细胞移植后能够不同程度地缓解阿尔茨海默病患者的症状,在阿尔茨海默病的治疗中表现出很好的潜力。
目的：总结了干细胞治疗阿尔茨海默病的研究现状，并展望了其应用前景。
方法：应用计算机检索CNKI和PubMed数据库中1981-01/2011-08关于干细胞移植治疗阿尔茨海默病的文章，在标题和摘要中以“阿尔茨海默病；干细胞；间充质干细胞；移植”或“Alzheimer’s disease; stem cell; mesenchymal stem cells; transplantation”为检索词进行检索。选择文章内容与干细胞移植治疗阿尔茨海默病相关，同一领域文献则选择近期发表或发表在权威杂志文章。初检得到122篇文献，根据纳入标准选择17篇文章进行综述。
结果与结论：对阿尔茨海默病病理改变及发病机制的了解，有利于选择更灵敏的阿尔茨海默病检测的生物标志物，有效预防和治疗阿尔茨海默病。线粒体DNA变化的氧应激，免疫应答的参与等在阿尔茨海默病的发病过程中都发挥关键作用，而且可能是多因素协同作用。通过对干细胞治疗阿尔茨海默病的机制研究指导其临床方面的应用。

关键词: 阿尔茨海默病, 间充质干细胞, 移植, 神经退行性疾病, 骨髓来源, 干细胞

Abstract:

BACKGROUND: Neural stem cells (NSCs) and bone marrow-derived mesenchsymal stem cells transplantation would alleviate the symptoms of Alzheimer’s disease patients and therefore shows the potential to treat Alzheimer’s disease.
OBJECTIVE: To review the research development of stem cells therapy for Alzheimer's disease, and to discusses its potential applications.
METHODS: The articles about stem cells transplantation for the treatment of Alzheimer's disease were retrieved in CNKI database and PubMed database from January 1981 to August 2011. The index words in titles and abstracts were “Alzheimer’s disease, stem cells, mesenchymal stem cells, transplantation”. The articles related to stem cells transplantation for the treatment of Alzheimer's disease and those which were recently published in famous Scholarly Journals in the same field were selected. At last, we got two hundred and forty-one theses. According to the inclusion criteria, 28 documents were finally selected.
RESULTS AND CONCLUSION: Understanding of the pathological changes and pathogenesis of Alzheimer's disease would be helpful to select sensitive biological markers and carry out effective preventions and treatments for Alzheimer's disease. Mitochondrial DNA changes of oxygen stress and the immune responses in Alzheimer's disease played a key role in the pathological process of Alzheimer's disease, and maybe have a good synergistic effect. The mechanism research regarding stem cells transplantation for treatment of Alzheimer's disease can guide the clinical applications.

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