中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (23): 4296-4300.doi: 10.3969/j.issn.1673-8225.2012.23.023

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

干细胞移植对心肌电活动的影响

郭逸鸿，张晓刚   

  1. 重庆医科大学附属第一医院心内科，重庆市 400016
  • 收稿日期:2011-10-13 修回日期:2011-11-26 出版日期:2012-06-03 发布日期:2013-11-06
  • 通讯作者: 张晓刚，博士，教授，主任医师，硕士生导师，重庆医科大学附属第一医院心内科，重庆市 400016 zxg0233@sina.com
  • 作者简介:郭逸鸿★，女，1987年生，重庆医科大学在读硕士，主要从事诱导多能干细胞(iPS)移植在治疗心血管疾病中的应用研究。 gyh4268@163.com

Effects of stem cells transplantation on cardiac electrical activity

Guo Yi-hong, Zhang Xiao-gang   

  1. Department of Cardiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
  • Received:2011-10-13 Revised:2011-11-26 Online:2012-06-03 Published:2013-11-06
  • Contact: Zhang Xiao-gang, M.D., Professor, Master’s supervisor, Chief physician, Department of Cardiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China zxg0233@sina.com
  • About author:Guo Yi-hong★, Studying for master’s degree, Department of Cardiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China gyh4268@163.com

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摘要：

背景：离子通道是心肌细胞最重要的电生理特性之一，干细胞向心肌细胞分化过程中离子通道的变化情况，以及干细胞移植到心脏后对心肌组织电生理学特性的影响是心血管疾病研究的新热点。
目的：综述干细胞移植对心肌电活动影响的现状及新进展。
方法：应用计算机检索维普、PubMed及SpringerLink数据库中2000-01/2011-05关于干细胞移植对心肌电活动影响的文章，在标题和摘要中以“骨髓间充质干细胞、胚胎干细胞、诱导多能干细胞、心肌电活动、离子通道”或“Bone marrow mesenchymal stem cells、Embryonic stem cells、Induced pluripotent stem cells、Cardiac electrical activity、Ion channels”为检索词进行检索。
结果与结论：最终选择21篇文献进行分析。目前国内外临床实验均未观察到干细胞移植产生的致命性心律失常，但一些心电活动和离子通道动力学在移植后发生改变，因此干细胞移植对心肌电生理的影响不容小觑。诱导多能干细胞不仅能够分化为心肌细胞，而且具有与心肌类似的电生理活动，在受损心肌进行再生性治疗中必将得到更加广泛的研究及应用。

关键词: 心肌电活动, 干细胞移植, 诱导多能干细胞, 离子通道, 综述文献, 干细胞

Abstract:

BACKGROUND: Myocardial ion channel is one of the most important electrophysiological characteristics. But the changes in ion channels during the process of stem cells differentiation into cardiac cells and the impact on the electrophysiological properties of myocardial tissue remain unclear.
OBJECTIVE: To summarize the effects of stem cells transplantation on cardiac electrical activity.
METHODS: VIP database, PubMed database and SpringerLink database (2000-01/2011-05) were used to search the related articles about the effect of stem cells transplantation on cardiac electrical activity. The key words were “bone marrow mesenchymal stem cells, embryonic stem cells, induced pluripotent stem cells, cardiac electrical activity, ion channels” in English and in Chinese.
RESULTS AND CONCLUSION: A total of 21 articles were included to review. The life threatening arrhythmia caused by stem cells transplantation has not been observed in a larger amount of clinical experiments at home or abroad, but some cardiac electrical activities and ion channel dynamics were changed after stem cells transplantation, the effects of stem cells transplantation on cardiac electrical activity should not be underestimated. The induced pluripotent stem cells can not only differentiate into myocardial cells, but also have the similar electrical activities with them. Therefore, it must be wildly studied and applied in the regenerative treatment of damaged myocardium.

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