中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (14): 2617-2620.doi: 10.3969/j.issn.1673-8225.2012.14.029

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

膝关节半月板损伤与骨髓基质干细胞

李  杰1，刘富顺2   

  1. 1广西体育高等专科学校，广西壮族自治区南宁市    530012；2浙江警察学院警体部，浙江省杭州市310053
  • 收稿日期:2011-09-12 修回日期:2011-10-09 出版日期:2012-04-01 发布日期:2012-04-01
  • 作者简介:李杰，男，1964年生，广西壮族自治区鹿寨县人，汉族，1987年广西医学院毕业，讲师，主要从事运动损伤保健与康复。lijiegxtz@126.com

Bone marrow stromal stem cells repair knee meniscus injury

Li Jie1, Liu Fu-shun2   

  1. 1Guangxi Sports College, Nanning  530012, Guangxi Zhuang Autonomous Region, China; 2Police Physical Department of Zhejiang Police College, Hangzhou  310053, Zhejiang Province, China
  • Received:2011-09-12 Revised:2011-10-09 Online:2012-04-01 Published:2012-04-01
  • About author:Li Jie, Lecturer, Guangxi Sports College, Nanning 530012, Guangxi Zhuang Autonomous Region, China lijiegxtz@126.com

PDF

299

被引次数

10

摘要：

背景：骨髓基质干细胞移植是解决软骨组织缺损最有前景的手段之一，骨髓基质干细胞也成为软骨组织修复应用较广泛的重要种子细胞。
目的：分析骨髓基质干细胞在半月板损伤和软骨损伤方面的应用情况，为膝关节半月板损伤的修复和治疗提供理论参考。
方法：由第一、二作者共同检索1997/2011PubMed数据库及清华同方数据库，中文关键词为“骨髓间充质干细胞，膝关节半月板损伤”，英文关键词为“bone marrow stromal cells；knee joint meniscus injury”。纳入骨髓基质干细胞修复膝关节半月板损伤的相关文献26篇进行分析。
结果与结论：骨髓基质干细胞在治疗和修复膝关节半月板损伤方面具有独到的优势，包括其损伤面较小，方便易行，没有后遗症，并克服了切除半月板引起的形态和生物功能的改变，避免了因异体材料移植引起的膝载荷传导紊乱和晚期骨性关节炎发病的可能，与保留半月板修复其功能的临床治疗理念较为接近，并成为当前和今后治疗与修复膝关节半月板损伤的新思路。在其修复治疗的过程中，其关键问题在于一方面如何获得大量纯化的骨髓基质干细胞并在体外定向诱导为半月板软骨表型的细胞，另一方面是诱导分化的确切机制研究。
关键词：骨髓基质干细胞；膝关节；半月板损伤；康复；诱导分化
doi:10.3969/j.issn.1673-8225.2012.14.029

关键词: 骨髓基质干细胞, 膝关节, 半月板损伤, 康复, 诱导分化

Abstract:

BACKGROUND: Bone marrow stromal stem cells transplantation has become one of the most perspective methods to solve the problem of cartilage tissue defects, and bone marrow stromal stem cells have become the important seed cells to repair the cartilage tissue defects.
OBJECTIVE: To analyze the application of bone marrow stromal stem cells on meniscus injury and cartilage injury, in order to provide the theory reference for the repair and treatment of knee meniscus injury.
METHODS: The PubMed database and Tongfang database 1997/2011 were retrieved by the first and second authors with the key words “Bone Marrow Stromal Cells; Knee Joint Meniscus Injury” in English and Chinese. A total of 26 articles related to bone marrow stromal stem cells for repair of the knee meniscus injury were included to analysis.
RESULTS AND CONCLUSION: Bone marrow stromal cells in the repair and treatment of knee meniscus injury have unique advantages, including less damage surface, convenient and easy to operate, no complications, and no changes in morphology and biological function caused by the removal of the meniscus, and without load conduction disorders and caused by allogeneic material transplantation and the possibility of late onset osteoarthritis. The treatment concept of bone marrow stromal stem cells transplantation was close to meniscus injury, and became the new ideas in the current and future treatment and repair of knee meniscus injury. During the process of repair treatment, the key was how to obtain a large amount of purified bone marrow stromal stem cells and induce into the meniscus cartilage phenotype in vitro. The exact mechanism underlying induction of differentiation should be further investigated.

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