中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (14): 2621-2624.doi: 10.3969/j.issn.1673-8225.2012.14.030

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

骨髓间充质干细胞及细胞因子在股骨头坏死治疗中的应用与展望★

左思力，龚跃昆   

  1. 昆明医学院附属第一医院骨科，云南省昆明市 650032
  • 收稿日期:2011-10-27 修回日期:2011-11-13 出版日期:2012-04-01 发布日期:2012-04-01
  • 通讯作者: 龚跃昆，博士，硕士生导师，主任医师，教授，昆明医学院附属第一医院骨科，云南省昆明市 650032
  • 作者简介:左思力★，男，1985年生，四川省成都市人，汉族，昆明医学院附属第一医院在读硕士，医师，主要从事骨与关节损伤与修复研究。zuosili@126.com

Application and prospects of bone marrow mesenchymal stem cells and cytokines in the treatment of femoral head necrosis 

Zuo Si-li, Gong Yue-kun   

  1. Department of Orthopedics, First Affiliated Hospital of Kunming Medical University, Kunming  650032, Yunnan Province, China
  • Received:2011-10-27 Revised:2011-11-13 Online:2012-04-01 Published:2012-04-01
  • Contact: author: Gong Yue-kun, Doctor, Master’s supervisor, Professor, Chief physician, Department of Orthopedics, First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan Province, China
  • About author:Zuo Si-li★, Studyig for master’s degree, Physician, Department of Orthopedics, First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan Province, China zuosili@126.com

PDF

495

被引次数

19

摘要：

背景：单纯应用骨髓间充质干细胞治疗股骨头坏死的效果较差，若同时加入相关细胞因子可更好的发挥作用。
目的：综述相关细胞因子诱导间充质干细胞在股骨头坏死治疗方面的应用。
方法：由第一作者检索1989/2009 PubMed数据库及万方数据库有关治疗股骨头坏死的新进展、骨髓间充质干细胞治疗骨科相关疾病、可促进间充质干细胞向成骨细胞分化的相关细胞因子及其作用机制等文献报道。
结果与结论：骨形态发生蛋白、成骨生长肽、血管内皮生长因子、软骨源性形态发生蛋白1、生长转化因子β、胰岛素样生长因子1、血小板衍生生长因子等细胞因子被证实可诱导骨髓间充质干细胞分化为成骨细胞、软骨细胞，促进骨痂的愈合。因此临床中将骨髓间充质干细胞与细胞因子诱导技术相结合治疗股骨头坏死可最大程度优化治疗效果。

关键词: 细胞因子, 股骨头坏死, 骨髓间充质干细胞, 碱性成纤维细胞生长因子, 骨形态发生蛋白, 成骨生长肽

Abstract:

BACKGROUND: Simple application of bone marrow mesenchymal stem cells (BMSCs) to treat femoral head necrosis has a poor effect, Addition of cytokines during BMSCs application plays a better role.
OBJECTIVE: To summarize the application of BMSCs induced by related cytokines on the treatment of femoral head necrosis.
METHODS: The PubMed database and Wanfang database from 1989 to 2009 were searched by the first author. The articles were related to the new progress in the treatment of femoral head necrosis, the application of BMSCs on the treatment of bone-related diseases, the related cytokines which could induce BMSCs to differentiate into osteoblasts and the underlying mechanism.
RESULTS AND CONCLUSION: The cytokines such as bone morphogenetic proteins, osteogenic growth peptide, vascular endothelial growth factor, cartilage-derived morphogenetic protein 1, transforming growth factor β, insulin-like growth factor-1, platelet-derived growth factor could induce the BMSCs to differentiate into osteoblasts and chondrocytes, and could promote the recovery of callus. Thus, the clinical application of cytokine induced BMSCs could optimize the treatment of femoral head necrosis. 

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