中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (12): 2110-2114.doi: 10.3969/j.issn.1673-8225.2012.12.005

• 组织工程骨及软骨材料 tissue-engineered bone and cartilage materials • 上一篇    下一篇

骨水泥充填椎体成形治疗骨质疏松性椎体压缩骨折：6年随访★

任  炼1，李志忠1，隋  杰2，林永新1，焦根龙1，孙国栋1   

  1. 1暨南大学附属第一医院骨科，广东省广州市  510630；2长葛市人民医院骨科一病区，河南省长葛市  461500
  • 收稿日期:2011-12-07 修回日期:2012-01-30 出版日期:2012-03-18 发布日期:2012-03-18
  • 通讯作者: 李志忠，主任医师，教授，博士生导师，暨南大学附属第一医院骨科，广东省广州市 510630
  • 作者简介:任炼★，男，1983年生，湖南省长沙县人，汉族，暨南大学在读硕士，医师，主要从事脊柱外科与骨组织工程研究。

Vertebroplasty with bone cement in the treatment of osteoporotic vertebral compression fractures★A 6-year follow-up

Ren Lian1, Li Zhi-zhong1, Sui Jie2, Lin Yong-xin1, Jiao Gen-long1, Sun Guo-dong1   

  1. 1Department of Orthopedics, First Affiliated Hospital of Jinan University, Guangzhou  510630, Guangdong Province, China; 2First Ward, Department of Orthopedics, Changge Municipal People’s Hospital, Changge  461500, Henan Province, China
  • Received:2011-12-07 Revised:2012-01-30 Online:2012-03-18 Published:2012-03-18
  • Contact: author: Li Zhi-zhong, Chief physician, Professor, Doctoral supervisor, Department of Orthopedics, First Affiliated Hospital of Jinan University, Guangzhou 510630, Guangdong Province, China lizhizhong1@ medmail.com.cn
  • About author:Ren Lian★, Studying for master’s degree, Physician, Department of Orthopedics, First Affiliated Hospital of Jinan University, Guangzhou 510630, Guangdong Province, China renlian2004@ yahoo.com.cn

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摘要：

李志忠，主任医师，教授，博士生导师，暨南大学附属第一医院骨科，广东省广州市  510630背景：经皮椎体成形应用于骨质疏松性椎体压缩骨折的治疗已取得很好的效果，但其远期的疗效及对患者的影响至今少有报道。
目的：随访分析骨水泥充填椎体成形治疗骨质疏松性椎体压缩骨折的远期疗效。
方法：选择骨质疏松性椎体压缩性骨折并行经皮椎体成形治疗的患者34例，对成形前、成形后1周和成形后平均6年进行目测类比评分及标准侧位X射线片上病变椎体高度、脊柱后凸畸形角进行测量与比较，观察成形后远期疗效。
结果与结论：成形后1周及平均6年的脊柱后凸畸形角较成形前降低，成形后随访期内变化不明显。成形后椎体高度较成形前明显恢复(P < 0.01)；成形后1周及成形后平均6年随访期内椎体高度变化不显著。成形后1周及成形后平均6年的目测类比评分较成形前降低明显(P < 0.01)，但随时间延长，目测类比评分有升高趋势。以上各指标在成形后平均6年随访中基本维持稳定。结果证实，椎体成形治疗骨质疏松性椎体压缩骨折安全而有效，远期疗效肯定。

关键词: 经皮椎体成形, 椎体, 骨折, 骨质疏松, 椎体压缩性骨折, 远期疗效, 生物材料

Abstract:

BACKGROUND: Percutaneous vertebroplasty for osteoporotic vertebral compression fractures has achieved very good results, but its long-term efficacy as well as impact on patients has been rarely reported so far.
OBJECTIVE: To investigate the long-term effect of vertebroplasty with bone cement on osteoporotic vertebral compression fractures through a follow-up.
METHODS: Thirty-four patients with osteoporotic vertebral compression fractures who had undergone percutaneous vertebroplasty were recruited. Visual analogue scale scoring was measured and compared as well as lesioned vertebral height and kyphosis angle shown on lateral X-ray examination prior to, 1 week and 6 years after percutaneous vertebroplasty.
RESULTS AND CONCLUSION: The kyphosis angle was improved 1 week and 6 years after percutaneous vertebroplasty, and it changed insignificantly during the follow-up period. The vertebral height was also improved significantly after percutaneous vertebroplasty (P < 0.01); however, there was no obvious variation in the vertebral height at 1 week and 6 years after percutaneous vertebroplasty. The visual analogue scale exhibited an improvement after percutaneous vertebroplasty (P < 0.01); however, with time going by, the scoring on the visual analogue scale had an increased tend. All the parameters remained stable and had no large fluctuations. It is proved that the percutaneous vertebroplasty is effective and safe to treat osteoporotic vertebral compression fractures with an excellent long-term effect.

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