中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (8): 1417-1420.doi: 10.3969/j.issn.1673-8225.2012.08.019

• 材料生物相容性 material biocompatibility • 上一篇    下一篇

新型硅橡胶人工晶状体兔眼植入的生物相容性评价**★

刘晓娜，徐  栩，李玲琍，罗  丽，南开辉，陈  浩   

  1. 温州医学院附属眼视光医院，浙江省温州市  325027
  • 收稿日期:2011-08-25 修回日期:2011-09-23 出版日期:2012-02-19 发布日期:2012-02-19
  • 通讯作者: 陈浩，博士，副教授，硕士生导师，温州医学院附属眼视光医院，浙江省温州市 325027 chenhao823@ mail.eye.ac.cn
  • 作者简介:刘晓娜★，女，1986年生，河北省保定市人，汉族，温州医学院在读硕士，主要从事眼科医用生物材料的安全性评价方面的研究。 liuxiaona914811@163.com
  • 基金资助:

    浙江省教育厅高校科研计划项目(Y 201016694)，温州市科技局项目(Y 20090245)

Biocompatibility of new silicone intraocular lenses implanted into rabbit eyes

Liu Xiao-na, Xu Xu, Li Ling-li, Luo Li, Nan Kai-hui, Chen Hao   

  1. Hospital of Optometry & Ophthalmology, Wenzhou Medical College, Wenzhou  325027, Zhejiang Province, China
  • Received:2011-08-25 Revised:2011-09-23 Online:2012-02-19 Published:2012-02-19
  • Contact: Chen Hao, Doctor, Associate professor, Master’s supervisor, Hospital of Optometry & Ophthalmology, Wenzhou Medical College, Wenzhou 325027, Zhejiang Province, China chenhao823@ mail.eye.ac.cn
  • About author:Liu Xiao-na★, Studying for master’s degree, Hospital of Optometry & Ophthalmology, Wenzhou Medical College, Wenzhou 325027, Zhejiang Province, China liuxiaona914811@ 163.com
  • Supported by:

    University Research Project of Education Department of Zhejiang Province, No. Y 201016694*; Project of Science and Technology Agency of Wenzhou, No. Y 20090245*

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摘要：

背景：软性人工晶状体的材料主要有硅凝胶、疏水性丙烯酸酯、亲水性丙烯酸酯和水凝胶等，但各材料优缺点不同，其长期生物学特性仍待临床检验。为改善白内障术后的视觉质量，提高人工晶状体的生物相容性及光学性能，进行新材料的开发是目前研究的热点。
目的：评价自主研制的新型硅橡胶后房型人工晶状体兔眼植入半年的生物相容性。
方法：选取20只新西兰白兔，均单眼行透明晶状体超声乳化吸除术联合人工晶状体植入，实验组(10眼)植入自主研制的硅橡胶(T-10)后房型人工晶状体，对照组(10眼)植入现已上市的硅凝胶后房型人工晶状体(EFC550)。
结果与结论：植入后早期，两组兔眼均有较重的前房渗出，差异无显著性意义。两组兔眼后囊膜混浊程度差异无显著性意义。植入后90 d及180 d，实验组虹膜后粘连情况轻于对照组。可见新型硅橡胶人工晶状体色素层生物相容性优于硅凝胶人工晶状体，具有临床可应用性。

关键词: 人工晶状体, 兔, 裂隙灯观察, 生物相容性, 硅橡胶, 硅凝胶

Abstract:

BACKGROUND: The soft intraocular lenses materials mainly include silica gel, hydrophobic acrylate, hydrophilic acrylate and hydrogel. The long-term biological characteristics of these materials are unclear because of their own advantages and disadvantages. Currently, the development of new materials is a hotspot research in order to improve the biocompatibility and optical property of intraocular lenses to achieve well visual quality of patients after cataract surgery.
OBJECTIVE: To evaluate the biocompatibility of self-prepared new silicone intraocular lenses (IOLs) implanted into rabbit eyes for 6 months.
METHODS: Twenty New Zealand albino rabbits undergoing phacoemulsification combined with intraocular lenses implantation in the left eye were divided into two groups randomly. The experimental group was implanted with T-10 IOLs. The rabbits implanted with EFC550 IOLs were taken as control.
RESULTS AND CONCLUSION: Serious anterior chamber exudation was observed at later stage after operation in both groups and the difference in exudation between the two groups was not significant. The degrees of the posterior capsule opacification of the rabbit eyes in the experimental and control groups had no difference. The degree of the posterior synechia in the experimental group was lower than that in the control group at 90 and 180 days. The uveal biocompatibility of T-10 IOLs is better than that of the EFC550 IOLs. T-10 IOLs have a clinical applicability

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