中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (7): 1180-1183.doi: 10.3969/j.issn.1673-8225.2012.07.010

• 血管组织构建 vascular tissue construction • 上一篇    下一篇

长春瑞滨上调小鼠尾静脉血管内皮细胞Toll样受体4的表达★

钱韦韦，陈  翀，曹  江，高立艳，周  莹，谭迎春，李振宇    

  1. 徐州医学院附属医院血液科，江苏省徐州市  221002
  • 收稿日期:2011-07-11 修回日期:2011-08-06 出版日期:2012-02-12 发布日期:2012-02-12
  • 通讯作者: 李振宇，副教授，硕士生导师，徐州医学院附属医院血液科，江苏省徐州市 221002 lizhenyumd@163.com
  • 作者简介:钱韦韦★，女，1982年生，江苏省徐州市人，汉族，徐州医学院在读硕士，讲师，主要从事静脉炎的基础和临床研究。Xxb_1983@yahoo.com.cn

Toll like receptor-4 is upregulated in mouse tail vein endothelial cells after Vinorelbine injection

Qian Wei-wei, Chen Chong, Cao Jiang, Gao Li-yan, Zhou Ying, Tan Ying-chun, Li Zhen-yu   

  1. Department of Hematology, Affiliated Hospital of Xuzhou Medical College, Xuzhou  221002, Jiangsu Province, China
  • Received:2011-07-11 Revised:2011-08-06 Online:2012-02-12 Published:2012-02-12
  • Contact: Li Zhen-yu, Associate professor, Master's supervisor, Department of Hematology, Affiliated Hospital of Xuzhou Medical College, Xuzhou 221002, Jiangsu Province, China lizhenyumd@163.com
  • About author:Qian Wei-wei★, Studying for master's degree, Lecturer, Department of Hematology, Affiliated Hospital of Xuzhou Medical College, Xuzhou 221002, Jiangsu Province, China xxb_1983@yahoo.com.cn

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摘要：

背景：Toll样受体4除与抗感染免疫有关外，在心肌梗死、脑梗死等组织损伤和自身免疫病等非感染性炎症反应中也发挥着重要作用。
目的：观察长春瑞滨对小鼠尾静脉血管内皮细胞Toll样受体4表达的影响。
方法：取20只BALB/c小鼠，随机分为实验组和对照组，实验组尾静脉注射长春瑞滨，对照组注射生理盐水。
结果与结论：注射后48 h，实验组小鼠尾静脉血管出现内皮细胞脱落、血栓形成和炎细胞浸润，损伤部位内皮细胞高表达Toll样受体4；对照组小鼠尾静脉血管无明显损伤表现，血管内皮细胞Toll样受体4阴性或弱表达。表明长春瑞滨上调了小鼠尾静脉血管内皮细胞Toll样受体4表达，提示Toll样受体4可能参与了长春瑞滨致静脉血管内皮损伤的发生过程。

关键词: 长春瑞滨, 静脉内皮损伤, Toll样受体4, 炎症, 机制

Abstract:

BACKGROUND: Toll like recptor-4 plays a key role in anti-infection immunity. Recently, Toll like recptor-4 has also been reported as an important moderator in noninfective inflammation reactions, including autoimmune diseases and tissue damage, such as myocardial infarction and cerebral infarction.
OBJECTIVE: To investigate the effect of Vinorelbine on the expression level of Toll like recptor-4 in mouse tail vein endothelial cells.
METHODS: A number of 20 BALB/c mice were randomly divided into to experimental group and control group. Experimental mice were injected with Vinorelbine, while the control mice were injected with saline.
RESULTS AND CONCLUSION: At the 48th hour after Vinorelbine injection, mouse tail vein endothelial cells became disrupted, and the tail vein presented phenomena of thrombosis and inflammatory cell infiltration. Toll like recptor-4 was positive in endothelial cells of damage location. In the control group, the tail vein vessels were intact and Toll like recptor-4 expression in endothelial cells was negative or very low. The results indicate that Toll like recptor-4 expression is up-regulated by Vinorelbine in mouse tail vein endothelial cells. It suggests that Toll like recptor-4 may involve in the development of vein vascular endothelial injury induced by Vinorelbine.

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