中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (7): 1153-1156.doi: 10.3969/j.issn.1673-8225.2012.07.004

• 骨组织构建 bone tissue construction • 上一篇    下一篇

电刺激与运动联合干预绝经后骨质疏松模型大鼠骨代谢及血清学指标的改变

覃荣周，谢江涛   

  1. 阿坝师范高等专科学校体育系，四川省汶川县 623002
  • 收稿日期:2011-12-01 修回日期:2012-01-06 出版日期:2012-02-12 发布日期:2012-02-12
  • 作者简介:覃荣周，男，1977年生，广东省罗定市人，汉族，2002年成都体育学院毕业，讲师，主要从事运动与慢性病防治工作。 qrz100@126.com

Effect of electrical stimulation combined with exercise on the changes of bone metabolism and serum markers in postmenopausal osteoporosis rats

Qin Rong-zhou, Xie Jiang-tao   

  1. Department of Physical Education, Aba Teachers College, Wenchuan  623002, Sichuan Province, China
  • Received:2011-12-01 Revised:2012-01-06 Online:2012-02-12 Published:2012-02-12
  • About author:Qin Rong-zhou, Lecturer, Department of Physical Education, Aba Teachers College, Wenchuan 623002, Sichuan Province, China qrz100@126.com

PDF

295

被引次数

11

摘要：

背景：电刺激与运动皆能对去势大鼠骨代谢产生良好影响，但关于电刺激和运动联合干预去势大鼠至今少有报道。
目的：观察适宜健骨运动处方与电刺激联合干预对绝经后骨质疏松的影响。
方法：将大鼠随机分为假手术组，骨质疏松模型组，运动组，电刺激组和运动+电刺激组，后4组建立骨质疏松大鼠模型并进行相应的干预。
结果与结论：干预后60 d，与骨质疏松模型组比较，运动结合电刺激组骨钙素浓度增高(P < 0.05)，运动组、电刺激组、运动结合电刺激组抗酒石酸盐酸性磷酸酶活性低(P < 0.01)，雌二醇水平显著升高(P < 0.05)。结果证实，运动处方结合低频电刺激联合作用能够更好地促进骨质疏松模型大鼠骨形成和抑制骨吸收，减少破骨细胞分泌和阻止骨丢失。
关键词：电刺激；运动；骨质疏松；骨代谢；骨组织构建
doi:10.3969/j.issn.1673-8225.2012.07.004

关键词: 电刺激, 运动, 骨质疏松, 骨代谢, 骨组织构建

Abstract:

BACKGROUND: Both electrical stimulation and exercise has good effects on the bone metabolism of ovariectomized rats, but research on combined intervention of electrical stimulation and exercise in the ovariectomized rats is rare.
OBJECTIVE: To observe the effect of appropriate exercise prescription combined with electrical stimulation on postmenopausal osteoporosis.
METHODS: The rats were divided into sham, osteoporosis model, exercise, electrical stimulation, and exercise+electrical stimulation groups, and the osteoporosis models of the last four groups were established and corresponding interventions were performed.
RESULTS AND CONCLUSION: Compared with the sham group, osteocalcin concentration in the exercise+electrical stimulation group was increased (P < 0.05), and tartrate-resistant alkaline phosphatase activity was decreased (P < 0.01) but estradiol levels were significantly increased (P < 0.05) in the exercise, electrical stimulation and exercise+electrical stimulation groups at 60 days after intervention. The results confirmed that exercise prescription combined with the low frequency electrical stimulation can promote bone formation, inhibit bone resorption, reduce osteoclasts secrete and prevent bone loss in the rats model of osteoporosis.

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