中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (6): 1137-1140.doi: 10.3969/j.issn.1673-8225.2012.06.041

• 干细胞临床实践 clinical practice of stem cells • 上一篇    

自体骨髓单个核细胞移植治疗糖尿病下肢周围神经病变★

张会峰，赵志刚，袁慧娟，虎子颖，马跃华   

  1. 河南省人民医院二内内分泌科，河南省郑州市 450003
  • 收稿日期:2011-11-02 修回日期:2011-12-30 出版日期:2012-02-05 发布日期:2012-02-05
  • 通讯作者: 赵志刚，主任医师，博士生导师，河南省人民医院二内内分泌科，河南省郑州市 450003 zhf66677@163.com
  • 作者简介:张会峰★，男，1973年生，河南省汝南县人，汉族，2006年郑州大学毕业，硕士，副主任医师，主要从事内分泌及代谢病研究。 zhf666777@163.com

Autologous bone marrow mononuclear cells transplantation for the treatment of diabetic peripheral neuropathy of lower limb    

Zhang Hui-feng, Zhao Zhi-gang, Yuan Hui-juan, Hu Zi-ying, Ma Yue-hua   

  1. Second Department of Endocrinology, Henan Provincial People’s Hospital, Zhengzhou  450003, Henan Province, China
  • Received:2011-11-02 Revised:2011-12-30 Online:2012-02-05 Published:2012-02-05
  • Contact: Zhao Zhi-gang, Chief physician, Doctoral supervisor, Second Department of Endocrinology, Henan Provincial People’s Hospital, Zhengzhou 450003, Henan Province, China zhf66677@163.com
  • About author:Zhang Hui-feng★, Master, Associate chief physician, Second Department of Endocrinology, Henan Provincial People’s Hospital, Zhengzhou 450003, Henan Province, China zhf666777@163.com

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摘要：

背景：有研究表明移植骨髓单个核细胞治疗糖尿病下肢神经病变动物模型，通过在组织内能促进血管再生和增加血管生成因子及神经营养因子能改善临床症状。                            
目的：观察自体骨髓单个核细胞移植治疗糖尿病下肢周围神经病变的临床效果。
方法：30例糖尿病下肢闭塞症患者60条下肢，按治疗方式的不同分为2组：自体骨髓单个核细胞移植的治疗组和对侧下肢非自体骨髓单个核细胞移植的对照组，各30条下肢。
结果与结论：移植4周后，治疗组总有效率高于对照组(P < 0.05)。两组治疗后神经病变自主症状问卷神经病变主觉症状问卷评分均较治疗前明显降低，治疗组评分降低更明显(P < 0.01)，治疗组胫神经和腓总神经感觉和运动神经传导速度均较对照组快(P < 0.01)，患者未出现并发症和不良反应。说明自体骨髓单个核细胞移植治疗糖尿病下肢周围神经病变的临床效果较好。

关键词: 骨髓单个核细胞, 糖尿病周围神经病变, 自体移植, 下肢, 干细胞移植

Abstract:

BACKGROUND: Studies have shown that autologous bone marrow mononuclear cells transplantation can treat the diabetic peripheral neuropathy (DPN) of lower limb. It can improve the clinical symptom by promoting the angiogenesis and increasing vascular endothelial growth factor and neurotrophic factor.
OBJECTIVE: To evaluate the clinical efficacy of autologous bone marrow mononuclear cells transplantation for the treatment of DPN of lower limb.
METHODS: 60 lower limbs of 30 patients with DPN were divided into two groups by treatment method, 30 lower limbs received autologous stem cells transplantation (treatment group), 30 lower limbs did not receive autologous stem cells transplantation as control group (control group).
RESULTS AND CONCLUSION: At 4 weeks after transplantations, the total efficiency rate in treatment group was higher than that in control group (P < 0.05). After treatment, the TSS in two groups was significantly decreased, and the TSS in treatment group was lower than that in the control group (P < 0.01). The sensory nerve conduction velocity (SCV) and motor nerve conduction velocity (MCV) of tibial nerve and common peroneal nerve in treatment group were faster than that in the control group (P < 0.01), no related complication or adverse effects were observed in all patients. Autologous bone marrow stem cells transplantation has a good clinical efficacy on the treatment of lower limb DPN.

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