中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (6): 1111-1114.doi: 10.3969/j.issn.1673-8225.2012.06.035

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

骨髓间充质干细胞向神经细胞分化的相关信号通路研究现状*★

刘振东，王静成，杨建东   

  1. 江苏省苏北人民医院骨科，江苏省扬州市  225001
  • 收稿日期:2011-06-03 修回日期:2011-08-04 出版日期:2012-02-05 发布日期:2012-02-05
  • 通讯作者: 王静成，教授，硕士生导师，江苏省苏北人民医院骨科，江苏省扬州市 225001 001wjc@sina.com
  • 作者简介:刘振东★，男，1985年生，山东省德州市人，扬州大学医学院在读硕士，主要从事脊髓损伤修复的研究。liu-zhd@163.com
  • 基金资助:

    国家自然科学基金资助项目(81071466)。

Current researches of signal pathways involved in bone marrow mesenchymal stem cells differentiation into nerve cells  

Liu Zhen-dong, Wang Jing-cheng, Yang Jian-dong   

  1. Department of Orthopedics, Northern Jiangsu People’s Hospital, Yangzhou  225001, Jiangsu Province, China
  • Received:2011-06-03 Revised:2011-08-04 Online:2012-02-05 Published:2012-02-05
  • Contact: Wang Jing-cheng, Professor, Master’s supervisor, Department of Orthopedics, Northern Jiangsu People’s Hospital, Yangzhou 225001, Jiangsu Province, China 001wjc@sina.com
  • About author:Liu Zhen-dong★, Studying for master's degree, Department of Orthopedics, Northern Jiangsu People’s Hospital, Yangzhou 225001, Jiangsu Province, China liu-zhd@163.com
  • Supported by:

    the National Natural Science Foundation of China, No. 81071466*

PDF

338

被引次数

13

摘要：

背景：研究表明骨髓间充质干细胞被诱导分化成为神经细胞涉及的信号通路复杂多样。
目的：总结分析骨髓间充质干细胞向神经细胞分化过程中涉及的信号通路研究进展。
方法：应用计算机检索 CNKI 和Web of Science数据库中 2001-01/2010-12关于骨髓间充质干细胞分化为神经细胞的文章，以“骨髓间充质干细胞，神经细胞，信号”或“bone marrow mesenchymal stem cells，neural cells，signal”为检索词进行检索，重点对19篇文献进行分析。
结果与结论：细胞信号通路之间的关系错综复杂，相互之间或协调促进，或拮抗抑制，从而使得调节细胞的特异性应答更加精确。多条信号转导通路参与调控骨髓间充质干细胞向神经细胞分化，BMSCs向神经细胞的诱导分化过程中，所涉及的信号通路也并非独立存在，包括Ca2+信号通路、蛋白激酶 A信号通路、MEK-ERK通路、PI3K/AKt信号通路、MAPK信号通路等，信号通路之间关系复杂，彼此相互关联存在。
关键词：信号通路；骨髓间充质干细胞；神经细胞；分化；综述文献
doi:10.3969/j.issn.1673-8225.2012.06.035

关键词: 信号通路, 骨髓间充质干细胞, 神经细胞, 分化, 综述文献

Abstract:

BACKGROUND: Bone marrow mesenchymal stem cells (BMSCs) can be induced to differentiate into nerve cells in appropriate culture conditions.
OBJECTIVE: To review various signal pathways referred to the process of BMSCs differentiation into nerve cells.
METHODS: The databases of CNKI and Web of Science were searched for the articles about BMSCs differentiation into nerve cells published from January 2001 to December 2010. The key words were “bone marrow mesenchymal stem cells, neural cells, signal” in Chinese and English. Finally, 19 articles were included in result analysis.
RESULTS AND CONCLUSION: The relationship between cell signaling pathways is complex, and thus it is more accurate for the regulation of cell-specific responses. A series of signal transduction pathways involved in the regulation of bone marrow mesenchymal stem cells differentiate into nerve cells, including Ca2+ signaling pathway, protein kinase A signaling pathway, MEK-ERK pathway, PI3K/AKt signaling pathway, MAPK signaling pathway, which are interrelated with each other.

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