中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (6): 1099-1102.doi: 10.3969/j.issn.1673-8225.2012.06.032

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

干细胞移植联合免疫抑制治疗1型糖尿病的应用前景

李  芳，陈  慧   

  1. 兰州大学第二医院，甘肃省兰州市    730000
  • 收稿日期:2011-08-01 修回日期:2011-11-27 出版日期:2012-02-05 发布日期:2012-02-05
  • 通讯作者: 陈慧，博士，教授，主任医师，兰州大学第二医院，甘肃省兰州市 730000 chenhui02@sohu.com
  • 作者简介:李芳，女，河南省林州市人，汉族，兰州大学在读学士。lifang199093@163.com

Prospects of immunologic intervention combined with stem cells transplantation for the treatment of type 1 diabetes

Li Fang, Chen Hui   

  1. Second Hospital of Lanzhou University, Lanzhou  730000, Gansu Province, China
  • Received:2011-08-01 Revised:2011-11-27 Online:2012-02-05 Published:2012-02-05
  • Contact: author: Chen Hui, Doctor, Professor, Chief physician, Second Hospital of Lanzhou University, Lanzhou 730000, Gansu Province, China chenhui02@sohu.com
  • About author:Li Fang, Lanzhou University, Lanzhou 730000, Gansu Province, China lifang199093@163.com

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摘要：

背景：最近许多研究报道，干细胞细胞移植联合免疫干预可维持较长的胰岛素非依赖时间并减少糖尿病并发症的发生，但其机制尚不清楚。
目的：探讨应用干细胞移植联合免疫抑制治疗1型糖尿病的前景。
方法：应用计算机检索了Pubmed数据库(http://www.ncbi.nlm.nih.gov/pubmed/)、CNKI数据库(http://www.cnki.net)、维普数据库(http://www.cqvip.com/index.shtml)、万方数据库(http://g.wanfangdata.com.cn/)，检索范围为各数据库中的全部文章，英文检索词为“stem cells，diabetes mellitus，immunosuppression”，中文检索词为“干细胞，糖尿病”。从检索出的1 676篇文章中选择出文章内容与干细胞移植、免疫抑制治疗1型糖尿病密切相关、较为权威的文章，排除较陈旧文献及重复研究，共纳入中英文文章共29篇进一步分析。
结果与结论：就目前干细胞移植联合免疫抑制治疗1型糖尿病的研究现状，对国内外29篇相关文献和报道进行研究总结。结果显示干细胞移植联合免疫抑制治疗1型糖尿病可提高治疗效果，减少并发症的出现，具有良好的应用前景。

关键词: 免疫抑制, 1型糖尿病, 干细胞移植, 并发症, 综述文献

Abstract:

BACKGROUND: Recent studies show that the combination of immunological intervention and stem cells transplantation can maintain a comparatively long time of insulin—independent period and ease the occurrence of diabetic complications, but the mechanisms are still unknown．
OBJECTIVE: To comprehensively analyze the prospects of immunologic intervention combined with stem cells transplantation for the treatment of type 1 diabetes.
METHODS: The articles were retrieved in PubMed database (http://www.ncbi.nlm.nih.gov/pubmed/), CNKI database (http://www.cnki.net), Weipu database (http://www.cqvip.com/index.shtml) and Wanfang database (http://g.wanfangdata.com.cn/) with the key words of “Stem Cells, Diabetes Mellitus, Immunosuppression” in English or “Stem Cells, Diabetes Mellitus” in Chinese. Among 1676 related literatures, articles closely related with stem cells or immunologic intervention in the treatment of diabetes mellitus and doctorial articles were selected. The older literatures and repetitive researches were excluded, a total of 29 English articles were included for further analysis. 
RESULTS AND CONCLUSION: Based on the present status of the research on stem cells transplantation combined with immunologic intervention in the treatment of type 1 diabetes, 29 related literatures at home or abroad were used to research. 
The results showed that the combination of immunologic intervention and stem cells transplantation for the treatment of type 1 diabetes could increase the efficiency of the therapy, reduce the occurrence of complications, and has a good prospect.

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