中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (3): 431-433.doi: 10.3969/j.issn.1673-8225.2012.03.011

• 组织工程骨及软骨材料 tissue-engineered bone and cartilage materials • 上一篇    下一篇

纳米羟基磷灰石/聚磷酸钙纤维/聚乳酸骨组织工程复合支架的特性*★

朱凌云，王彦平，石宗利，张红梅   

  1. 兰州交通大学机电工程学院材料系，甘肃省兰州市  730070
  • 收稿日期:2011-07-03 修回日期:2011-08-30 出版日期:2012-01-15 发布日期:2012-01-15
  • 作者简介:朱凌云★，女，1975年生，甘肃省镇原县人，汉族，2005年兰州交通大学毕业，硕士，讲师，主要从事生物医用材料的研究。 zhuly@ mail.lzjtu.cn
  • 基金资助:

    甘肃省自然科学基金资助项目(096RJZA085)。

Fabrication and properties of nanometer hydroxyapatite/calcium polyphosphate/poly(L-lactic acid) composite scaffold for bone tissue engineering

Zhu Ling-yun, Wang Yan-ping, Shi Zong-li, Zhang Hong-mei   

  1. School of Mechatronic Engineering, Lanzhou Jiaotong University, Lanzhou  730070, Gansu Province, China
  • Received:2011-07-03 Revised:2011-08-30 Online:2012-01-15 Published:2012-01-15
  • About author:Zhu Ling-yun★, Master, Lecturer, School of Mechatronic Engineering, Lanzhou Jiaotong University, Lanzhou 730070, Gansu Province, China zhuly@mail.lzjtu.cn
  • Supported by:

    the Natural Science Foundation of Gansu Province, No. 096RJZA085*

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摘要：

背景：近年来国内外在骨与软骨组织支架复合材料方面进行了广泛的研究，取得了积极的成果，但仍存在许多问题。
目的：观察纳米羟基磷灰石/聚磷酸钙纤维/聚乳酸(HAP/CPP/PLLA)骨组织工程支架复合材料的特性。
方法：采用溶媒浇铸、粒子滤取技术与气体发泡相结合的方法制备出纳米HAP/CPP/PLLA骨组织工程支架复合材料，测试该支架复合材料的物理力学性能，并用扫描电子显微镜对其微观结构进行观察。
结果与结论：结果表明，纳米HAP/CPP/PLLA支架复合材料具有三维、连通、微孔网状结构，并具有较高的孔隙率和较好的压缩模量，是理想的骨组织工程支架材料。

关键词: 聚磷酸钙纤维, 纳米羟基磷灰石, 聚乳酸, 组织工程, 支架, 骨, 复合材料

Abstract:

BACKGROUND: Studies have achieved great progresses in compound materials for bone and cartilage tissue scaffolds. However, there are still some problems.
OBJECTIVE: To observe the fabrication and properties of nanometer hydroxyapatite/calcium polyphosphate/poly(L-lactic acid) (nanometer HAP/CPP/PLLA) composite scaffold for bone tissue engineering.
METHODS: Nanometer HAP/CPP/PLLA composite scaffold was prepared by solvent casting, particulate leaching combined with gas foaming. The properties of physical mechanics were tested.
RESULTS AND CONCLUSION: The experimental results showed that the composite scaffold had high porosity and compressive modulus as well as the three-dimensional, connectivity network microstructures. Therefore, this composite may be one of scaffold materials for bone tissue engineering with potentially broad applicability.

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