中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (1): 179-182.doi: 10.3969/j.issn.1673-8225.2012.01.039

• 干细胞临床实践 clinical practice of stem cells • 上一篇    下一篇

慢性肾脏病患者外周血干细胞因子水平的测定**★

仇方忻，张  伟，梁耀先，刘雪梅   

  1. Department of Nephrology, the Affiliated Hospital of Medical College, Qingdao University, Qingdao  266003, Shandong Province, China
  • 收稿日期:2011-06-21 修回日期:2011-09-07 出版日期:2012-01-01 发布日期:2012-01-01
  • 通讯作者: 刘雪梅，博士，副主任医师，青岛大学医学院附属医院肾内科，山东省青岛市 266003 liuxm2004@sina.com
  • 作者简介:仇方忻★，男，1984年生，山东省青岛市人，汉族，青岛大学医学院在读硕士，主要从事肾小管-间质疾病方面的研究。 qiufangxin@126.com
  • 基金资助:

    山东省医药卫生科技发展计划项目(2009HW031)；山东省2010年科技攻关项目(2010G0020222)

Levels of peripheral blood stem cell factors in patients with chronic kidney diseases

Qiu Fang-xin, Zhang Wei, Liang Yao-xian, Liu Xue-mei   

  1. 青岛大学医学院附属医院肾内科，山东省青岛市 266003
  • Received:2011-06-21 Revised:2011-09-07 Online:2012-01-01 Published:2012-01-01
  • Contact: Liu Xue-mei, Doctor, Associate chief physician, Department of Nephrology, the Affiliated Hospital of Medical College, Qingdao University, Qingdao 266003, Shandong Province, China liuxm2004@sina.com
  • About author:Qiu Fang-xin★, Studying for master’s degree, Department of Nephrology, the Affiliated Hospital of Medical College, Qingdao University, Qingdao 266003, Shandong Province, China
  • Supported by:

     the Medical and Health Development Project of Shandong Province, No. 2009HW031*; Shandong Province Scientific and Technological Projects 2010, No. 2010G0020222*

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摘要：

背景：干细胞因子是一种多功能细胞因子，在肾间质纤维化过程中起至关重要的作用。
目的：观察慢性肾脏病患者外周血干细胞因子水平的变化及其临床意义。
方法：采用ELISA法检测22例健康对照者和116例慢性肾脏病患者外周血干细胞因子水平，分析其与肾损害程度、贫血、脂质代谢紊乱、心血管病变、尿毒症皮肤瘙痒等的相关性。
结果与结论：慢性肾脏病患者外周血干细胞因子水平明显高于对照组(P < 0.01)；随着肾功能减退，外周血干细胞因子水平逐渐升高，各组间相比差异有显著性意义(P < 0.05)，且其水平与慢性肾脏病分期、血肌酐、尿素氮、C-反应蛋白、血酯、甲状旁腺激素呈正相关，与血红蛋白呈负相关，提示外周血干细胞因子的升高可能与慢性肾脏病进展、并发贫血等并发症的发生发展有重要关系。

关键词: 慢性肾脏病, 干细胞因子, 慢性肾小球肾炎, 糖尿病肾病, 良性小动脉性肾硬化症

Abstract:

BACKGROUND: Stem cell factor (SCF) is a multifunctional cytokine, which plays a crucial role in the process of renal interstitial fibrosis.
OBJECTIVE: To investigate the changes and clinical significance of serum SCF in patients with chronic kidney disease (CKD).
METHODS: Serum levels of SCF in 22 healthy controls and 116 patients with CKD were detected by enzyme-linked immunosorbent assay. The correlation between serum levels of SCF and renal damage degree, anemia, lipid metabolism disorders, cardiovascular disease, uremic pruritusda was analyzed.
RESULTS AND CONCLUSION: Serum levels of SCF in different CKD groups were significantly higher than that in control group (P < 0.01). Serum SCFs increased with the progression of renal dysfunction (P < 0.05), which were positively related to staging of CKD, serum creatinine, blood urea nitrogen, blood high C-reactive protein, lipids and parathormone, while negatively related to hemoglobin. The results suggested that serum SCF may play an importaut role in progression and medical camplications of CKD.

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