中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (1): 158-162.doi: 10.3969/j.issn.1673-8225.2012.01.034

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

脐带间充质干细胞在骨组织工程中的应用进展★

哈承志，王大伟   

  1. 聊城市人民医院关节外科，山东省聊城市  252000
  • 收稿日期:2011-06-08 修回日期:2011-07-20 出版日期:2012-01-01 发布日期:2012-01-01
  • 通讯作者: 王大伟，硕士生导师，主任医师，聊城市人民医院关节外科，山东省聊城市 252000
  • 作者简介:哈承志★，男，山东省聊城市人，汉族，泰山医学院在读硕士，主要从事骨组织工程研究。hcz19851013@163.com

Development of umbilical cord mesenchymal stem cells applied in bone tissue engineering

Ha Cheng-zhi, Wang Da-wei   

  1. Department of Joint Surgery, Liaocheng People’s Hospital, Liaocheng  252000, Shandong Province, China
  • Received:2011-06-08 Revised:2011-07-20 Online:2012-01-01 Published:2012-01-01
  • Contact: Wang Da-wei, Master’s supervisor, Chief physician, Department of Joint Surgery, Liaocheng People’s Hospital, Liaocheng 252000, Shandong Province, China
  • About author:Ha Cheng-zhi★, Studying for master’s degree, Taishan Medical University, Taian 271016, Shandong Province, China hcz19851013@163.com

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摘要：

背景：在骨组织工程领域，对新型种子细胞脐带间充质干细胞的研究逐渐增多。
目的：针对脐带间充质干细胞的分离培养、生物学特征及其在骨组织中所用载体进行综述。
方法：由第一作者应用计算机检索1999-01/2011-03 PubMed数据库及中国期刊全文数据库中有关脐带间充质干细胞分离培养、生物学特征、载体方面的文章。英文检索词为“umbilical cord stem cell，tissue engineering”，中文检索词为“脐带间充质干细胞，骨组织工程”。排除重复性研究及无关研究，共保留46篇文章进行综述。
结果与结论：脐带间充质干细胞具备胚胎和成体干细胞的多重特点，并且符合国际细胞疗法协会制定的间充质干细胞标准，但是脐带间充质干细胞的分离培养、诱导分化方法等尚不完善，应进一步深入分析。在脐带干细胞的载体方面，单一的材料支架目前研究已很多，对于复合材料载体与可注射性载体的研究可能是今后的热点。

关键词: 脐带间充质干细胞, 异体移植, 载体, 骨组织工程, 综述文献

Abstract:

BACKGROUND: In bone tissue engineering, the studies about umbilical cord mesenchymal stem cells (UC-MSCs) as the new seed cells are gradually increased.
OBJECTIVE: To review the isolation, culture, biology characteristics and the carrier used in bone tissue engineering of UC-MSCs.
METHODS: A computer-based online search of literatures published between January 1999 to March 2011 related to the isolation, culture, biology characteristics and the carrier of UC-MSCs was performed in PubMed database and CNKI database using the key words of “umbilical cord stem cell, bone tissue engineering” in English and in Chinese. Finally, 46 articles were included according to inclusion criteria.
RESULTS AND CONCLUSION: UC-MSCs possess multiple properties of embryon and adult stem cells. UC-MSCs have been proved to meet the criteria of MSCs published by the international society for cellular therapy. However, the isolation, culture, and differentiation of UC-MSCs are still unclear. There are many studies on single scaffolds as carrier, the research about composite carrier and injectable carrier may be the hotspot in the future.

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