中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (46): 8635-8638.doi: 10.3969/j.issn.1673-8225.2011.46.020

• 组织构建与生物活性因子 tissue construction and bioactive factors • 上一篇    下一篇

低强度脉冲超声波促进大鼠胫骨骨折愈合中血小板衍生生长因子和胰岛素样生长因子1的表达

李燕如，张长杰，刘汉良   

  1. 长沙市第三医院，湖南省长沙市410015
  • 收稿日期:2011-06-03 修回日期:2011-09-20 出版日期:2011-11-12 发布日期:2011-11-12
  • 通讯作者: 李燕如★，女，1981年生，汉族，湖南省益阳市人， 2008年中南大学湘雅医学院毕业，硕士，医师，主要从事骨关节损伤、神经系统损伤及慢性疼痛康复治疗。 liyangru2002@163.com
  • 作者简介:李燕如★，女，1981年生，汉族，湖南省益阳市人， 2008年中南大学湘雅医学院毕业，硕士，医师，主要从事骨关节损伤、神经系统损伤及慢性疼痛康复治疗。 liyangru2002@163.com

Low-intensity pulsed ultrasound promotes platelet derived growth factor and insulin-like growth factor 1 expression during tibial fracture healing in rats

Li Yan-ru, Zhang Chang-jie, Liu Han-liang   

  1. Third Hospital of Changsha, Changsha   410015, Hunan Province, China
  • Received:2011-06-03 Revised:2011-09-20 Online:2011-11-12 Published:2011-11-12
  • Contact: Li Yan-ru, Third Hospital of Changsha, Changsha 410015, Hunan Province, China liyangru2002@163.com
  • About author:Li Yan-ru★, Master, Physician, Third Hospital of Changsha, Changsha 410015, Hunan Province, China liyangru2002@163.com

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320

被引次数

8

摘要：

背景：有研究表明低强度脉冲超声波可以促进骨折愈合。
目的：观察低强度脉冲超声波对胫骨骨折大鼠血小板衍生生长因子及胰岛素样生长因子1表达的影响。
方法：实验采用单侧大鼠胫骨制作闭合骨折大鼠模型，建模后每日进行低强度脉冲超声波治疗。
结果与结论：建模后14，21 d，低强度脉冲超声波治疗的胫骨骨折模型大鼠骨痂量及厚度明显增高(P < 0.05)，建模后7，14 d，其骨痂血小板衍生生长因子和胰岛素样生长因子1表达也明显增高(P < 0.05)。说明低强度脉冲超声波促进大鼠胫骨骨折愈合中血小板衍生生长因子和胰岛素样生长因子1的表达，促进早期软骨细胞成熟和软骨内成骨，从而促进骨折的愈合。

关键词: 低强度脉冲超声波, 骨折愈合, 胫骨, 血小板衍生生长因子, 胰岛素样生长因子1, 骨组织工程

Abstract:

BACKGROUND: Low-intensity pulsed ultrasound has been demonstrated to promote fracture healing.
OBJECTIVE: To investigate the effects of low-intensity pulsed ultrasound on platelet derived growth factor and insulin-like growth factor 1 expression during tibial fracture healing in rats.
METHODS: Rat models of closed fracture in unilateral tibia were established and then low-intensity pulsed ultrasound treatment was daily performed.
RESULTS AND CONCLUSION: At 14 and 21 days after model preparation, bone calcus amount and thickness in rat tibial fracture models treated with low-intensity pulsed ultrasound were significantly increased (P < 0.05) and at 7 and 14 days after model preparation, platelet derived growth factor and insulin-like growth factor 1 expression in bone callus was significantly increased (P  < 0.05). These findings suggest that low-intensity pulsed ultrasound increases platelet derived growth factor and insulin-like growth factor 1 expression during tibial fracture healing in rats, accelerate chondrocytes maturation and endochondral ossification, and thereby promote fracture healing.

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