中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (44): 8350-8354.doi: 10.3969/j.issn.1673-8225.2011.44.046

• 器官移植学术探讨 academic discussion of organ transplantation • 上一篇    下一篇

细胞因子Th1/Th2偏移与运动及衰老的关系

杨德洪1，魏  勇2   

  1. 1上海应用技术学院体育教育部，上海市  201418
    2上海体育学院运动科学学院，上海市   200438
  • 收稿日期:2011-07-07 修回日期:2011-08-19 出版日期:2011-10-29 发布日期:2011-10-29
  • 作者简介:杨德洪★，男，1975年生，山东省临沂市人，汉族，2002年上海体育学院运动人体科学专业毕业，硕士，讲师，主要从事体育教学和运动医学的研究。 dehongy@126.com
  • 基金资助:

    上海市教委青年教师基金项目资助(03LQ05)；上海市重点学科建设项目(S30802)。

Relationship between exercise, senescence and Th1/Th2 cytokine shift

Yang De-hong1, Wei Yong2   

  1. 1Department of Physical Education, Shanghai Institute of Technology, Shanghai  201418, China
    2College of Sport Science, Shanghai University of Sport, Shanghai   200438, China
  • Received:2011-07-07 Revised:2011-08-19 Online:2011-10-29 Published:2011-10-29
  • About author:Yang De-hong★, Master, Lecturer, Department of Physical Education, Shanghai Institute of Technology, Shanghai 201418, China dehongy@126.com
  • Supported by:

    the Young Teacher Foundation of Shanghai Educational Committee, No. 03LQ05*; the Key Discipline Construction Program of Shanghai City, No. S30802*

PDF

670

被引次数

5

摘要：

背景：很多研究都提示机体衰老和疾病过程中均伴有Thl和Th2细胞因子平衡发生偏离的现象。
目的：就运动、衰老和免疫领域的细胞因子与Thl/Th2分化、衰老与Th1/Th2型细胞因子、Th1/Th2型细胞因子平衡在运动延缓衰老中的可能作用方面的研究进行归纳分析。
方法：检索1990/2011PubMed数据及万方数据库有关运动、免疫和衰老等方面的文献，英文检索词为“exercise，immune senescence”，中文检索词为“运动，衰老，免疫”。排除与研究目的无关和内容重复者。保留42篇文献做进一步分析。
结果与结论：随着增龄，老年人易出现T淋巴细胞克隆向Th1亚群分化，进而出现Th1型细胞因子分泌增多，抑制Th2型细胞因子的分泌，破坏了Thl/Th2平衡在机体免疫防御反应的调节中所具有关键性作用，导致糖尿病、肿瘤和自身免疫性疾病等发病率增加。大量研究也证实，运动可以延缓衰老，减少老年性疾病的发生率。是否可以通过Thl/Th2偏移及其偏移的逆转来解释呢？还有待科学实验来予以验证。

关键词: 细胞因子, Th1/Th2, 运动, 衰老, 免疫

Abstract:

BACKGROUND: Several studies have shown that Th1/Th2 cytokine shift exists during the process of aging and disease.
OBJECTIVE: To review and analyze the research about aging and immune cytokines and Th1/Th2 differentiation, aging and Th1/Th2 type cytokines, the possible role of Th1/Th2 cytokines balance in anti-aging.
METHODS: A computer-based retrieval was performed in PubMed (http://www.ncbi.nlm.nih.gov/PubMed) and Wanfang database (http://www.wanfangdata.com.cn) to search papers published between 1990-2011 using the key words “exercise, immune senescence” in Chinese and English. The papers with objective-independent and repetitive contents were excluded, and finally 42 papers were included for final analysis.
RESULTS AND CONCLUSION: Many studies have been done about the hot issue of’ exercise, immunity and aging” including Th1/Th2 balance, and the results also show that exercise can improve some aspects while inhibit anothers of immunity. However, the exact biological significance about the changes in the immune system after exercise is not clear. Wether exercise also has a positive effect on the prevention and treatment of the elderly prone diseases, and the specific mechanism of this positive effect need to be further studied.

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