中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (44): 8346-8349.doi: 10.3969/j.issn.1673-8225.2011.44.045

• 器官移植综述 organ transplantation review • 上一篇    下一篇

中国胰岛移植治疗1型糖尿病临床与研究现状

刘宝林，刘世庆，陈  洋，尚  宾，陈爱山，戴显伟   

  1. 中国医科大学附属盛京医院外科，辽宁省沈阳市  110004
  • 收稿日期:2011-06-01 修回日期:2011-08-25 出版日期:2011-10-29 发布日期:2011-10-29
  • 作者简介:刘宝林☆，男，1966年生，吉林省梨树县人，汉族，博士，教授，主任医师，主要从事普外科，微创外科，移植与移植免疫耐受方面的研究。 并列第一作者：刘世庆★，男，1983年生，辽宁省瓦房店市人，汉族，2009年中国医科大学毕业，硕士，助教，主要从事器官移植及麻醉方面的研究。
  • 基金资助:

    国家自然科学基金(30972908)；沈阳市科委自然科学基金(F10-205-1-36)。

Clinical and research status of islet transplantation for type 1 diabetes in China

Liu Bao-lin, Liu Shi-qing, Chen Yang, Shang Bin, Chen Ai-shan, Dai Xian-wei   

  1. Department of Surgery, Shengjing Hospital, China Medical University, Shenyang  110004, Liaoning Province, China
  • Received:2011-06-01 Revised:2011-08-25 Online:2011-10-29 Published:2011-10-29
  • About author:Liu Bao-lin☆, Doctor, Professor, Chief physician, Department of Surgery, Shengjing Hospital, China Medical University, Shenyang 110004, Liaoning Province, China liubl55@hotmail.com Liu Bao-lin and Liu Shi-qing equally contributed to this work.
  • Supported by:

    the National Natural Science Foundation of China, No. 30972908*; the Natural Science Foundation of Science and Technology Committee of Shenyang, No. F10-205-1-36*

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摘要：

背景：胰岛移植是治疗胰岛素敏感的1型糖尿病患者的有效方法。
目的：调查与评估中国胰岛移植治疗1型糖尿病的现状及面临的困境。
方法：从中国当代医学期刊目录数据库中检索并分析1980-01/2008-12发表的有关胰岛移植的文章，解析国家自然科学基金数据库中2002/2008有关胰岛移植的课题资助数据，评估国内胰岛移植的临床及基础研究现状。
结果与结论：共检索到有关胰岛移植的文章340篇，包括基础研究165篇(48.5%)，临床研究45篇(13.2%)，综述性文献130篇(38.2%)。绝大多数研究是经济发达地区完成的，爱得蒙顿方案对中国胰岛移植的发展产生巨大影响，近年来越来越多的胰岛移植课题得到国家自然科学基金的资助。然而，中国胰岛移植的发展依然面临供体缺乏、器官捐献系统尚未完善、资金短缺等困难。

关键词: 胰岛移植, 1型糖尿病, 研究, 临床, 调查分析

Abstract:

BACKGROUND: Islet transplantation is an effective therapy for type I diabetic patients sensitive to insulin.
OBJECTIVE: To investigate and evaluate the status and obstacles of islet transplantation in type I diabetes in China.
METHODS: Published articles reported from January 1980 to December 2008 on Chinese Medical Current Contents database, the national funds from 2002 to 2008 in the database of National Natural Science Foundation of China on islet transplantation were searched to analyze the status of islet transplant research and clinical practice in China.
RESULTS AND CONCLUSION: 340 articles were reported from 1980 to 2008 related to islet transplantation in China, including 165 (48.5%) basic research, 45 (13.2%) clinical research and 130 (38.2%) reviews. Most of researches were conducted in the developed regions in the east of China. The Edmonton protocol had a great impact on the islet transplant research in China, and many projects of islet transplant have been supported by the National Natural Science Foundation. However, there remains obstacles in this field, such as organ and capital shortage and incomplete organ donation system.

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