中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (41): 7747-7750.doi: 10.3969/j.issn.1673-8225.2011.41.037

• 组织构建学术探讨 tissue construction academic discussion • 上一篇    下一篇

组织工程化软骨修复关节软骨缺损

许荣耀，张  寿   

  1. 中南大学湘雅医学院附属海口医院骨科中心，海南省海口市 570208
  • 收稿日期:2011-04-24 修回日期:2011-07-18 出版日期:2011-10-08 发布日期:2011-10-08
  • 作者简介:许荣耀★，男，1983生，中南大学在读硕士，汉族，主要从事关节外科的诊治工作。 xry8888@ yeah.net
  • 基金资助:

    课题受海口市重点基金项目(2010-168)资助。

Tissue-engineered cartilage for treatment of articular cartilage defects

Xu Rong-yao, Zhang Shou   

  1. Department of Orthopedics, Haikou Hospital Affiliated to Xiangya School of Medicine, Central South University, Haikou  570208, Hainan Province, China
  • Received:2011-04-24 Revised:2011-07-18 Online:2011-10-08 Published:2011-10-08
  • About author:Xu Rong-yao★, Studying for master’s degree, Department of Orthopedics, Haikou Hospital Affiliated to Xiangya School of Medicine, Central South University, Haikou 570208, Hainan Province, China xry8888@yeah.net
  • Supported by:

    Key Foundation Program of Haikou City, No. 2010-168*

PDF

365

被引次数

3

摘要：

背景：目前治疗软骨缺损的方法均有明显缺陷，组织工程软骨修复关节软骨缺损为微创治疗软骨缺损提供了新方法。
目的：总结组织工程软骨应用于修复关节软骨缺损的新进展。
方法：由第一作者用计算机检索万方数据库(2000/2010)和PubMed数据库(2000/2010)，检索词分别为“软骨缺损，组织工程软骨”和“articular cartilage defects, tissue-engineered cartilage”，语言分别设定为中文和英文。从组织工程软骨及其新进展2方面进行总结，对组织工程软骨的发展及构建等方面进行介绍。共检索到666篇文献，按纳入和排除标准对文献进行筛选，共纳入23篇文章。
结果与结论：近年来随着细胞支架材料的不断发展和组织构建技术的日趋成熟，结合活性细胞和支架的组织工程软骨为微创修复关节软骨缺损提供了良好的治疗手段及方法，组织工程软骨修复软骨缺损是完全可行的，C-GP凝胶与种子细胞相容性好，可做为组织工程软骨的理想支架，但细胞支架的制备及选择仍然是组织工程软骨的热点和难点。

关键词: 组织工程软骨, 关节软骨, 缺损, 支架, 软组织构建

Abstract:

BACKGROUND: At present, the methods for treatment of articular cartilage defects have obvious shortcomings. Tissue-engineered cartilage for repair of articular cartilage defects provides a novel method to treat cartilage defects with minimal invasion.
OBJECTIVE: To summarize the research progress in tissue-engineered cartilage for repair of articular cartilage degects.
METHODS: A computer-based retrieval was performed by the first author in the Wanfang data (2000/2010)and Pubmed database (2000/2010) using the key words “articular cartilage defects, tissue-engineered cartilage” in English and Chinese. The development and construction of tissue-engineered cartilage were summarized. A total of 666 manuscripts were searched. According to inclusion and exclusion criteria, 23 manuscripts were included in the final analysis.
RESULTS AND CONCLUSION: With increasing development of cell scaffold material and tissue construction technique, tissue-engineered cartilage of active cells and scaffold material provides a novel therapeutic method for treatment of articular cartilage defects with minimal invasion, so tissue-engineered cartilage for treatment of cartilage defects is completely feasible, and C-GP gel has good compatibility with seeded cells and can be used as the ideal scaffold for tissue-engineered cartilage. But preparation and selection of cell scaffold remains a difficult problem for tissue-engineered cartilage.

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