中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (38): 7177-7180.doi: 10.3969/j.issn.1673-8225.2011.38.035

• 生物材料综述 biomaterial review • 上一篇    下一篇

乳酸-羟基乙酸共聚物多肽蛋白类药物微球控释系统的突释与控制

赵先英1，高继宁2，粟永萍2，刘毅敏1，肖  湘1   

  1. 1解放军第三军医大学药学院化学教研室，重庆市  400038
    2解放军第三军医大学全军复合伤研究所，重庆市纳米医药工程技术研究中心，重庆市  400038
  • 收稿日期:2011-03-04 修回日期:2011-04-29 出版日期:2011-09-17 发布日期:2011-09-17
  • 通讯作者: 高继宁，博士，解放军第三军医大学全军复合伤研究所，重庆市纳米医药工程技术研究中心，重庆市 400038
  • 作者简介:赵先英★，女，1966年生，河南省郸城县人，汉族，1991年四川大学毕业，硕士，教授，主要从事纳米材料方面的研究。 xianyingzhao@yahoo.com.cn

Burst release and control of the delivery system of protein/peptide drug loaded poly(lactic-co-glycolic acid) microspheres

Zhao Xian-ying1, Gao Ji-ning2, Su Yong-ping2, Liu Yi-min1, Xiao Xiang1   

  1. 1Department of Chemistry, College of Laboratory Medicine and Pharmacy, Third Military Medical University, Chongqing  400038, China
    2Institute of Combined Injury, State Key Laboratory of Trauma, Burns and Combined Injury, Chongqing Engineering Research Center for Nanomedicine, Third Military Medical University, Chongqing  400038, China
  • Received:2011-03-04 Revised:2011-04-29 Online:2011-09-17 Published:2011-09-17
  • Contact: Gao Ji-ning, Doctor, Institute of Combined Injury, State Key Laboratory of Trauma, Burns and Combined Injury, Chongqing Engineering Research Center for Nanomedicine, Third Military Medical University, Chongqing 400038, China
  • About author:Zhao Xian-ying★, Master, Professor, Department of Chemistry, College of Laboratory Medicine and Pharmacy, Third Military Medical University, Chongqing 400038, China xianyingzhao@yahoo.com.cn

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摘要：

背景：突释问题是限制多肽蛋白类微球广泛应用的一个关键技术问题，已经成为PLGA微球控释系统面临的一个亟待解决的问题。
目的：分析近年来国内外对乳酸-羟基乙酸共聚物多肽蛋白类药物微球的突释与控制的研究，对突释的原因、影响突释的因素以及减少突释的方法与措施进行了详细的介绍。
方法：应用计算机检索CNKI和PubMed数据库中1999-01/2010-12关于乳酸-羟基乙酸共聚物多肽蛋白类药物微球控释系统研究的文章，在标题和摘要中以“聚乳酸-羟基乙酸；多肽；蛋白；微球；突释；控制”或“PLGA; peptide; protein ; microspheres; burst release; control”为检索词进行检索。通过阅读标题和摘要进行初选，排出较陈旧和重复研究文献，保留符合纳入标准的文献24篇。
结果与结论：对乳酸-羟基乙酸共聚物多肽蛋白类药物微球突释机制的理解，可以更好地实现对微球突释的控制，以扩大多肽蛋白类药物在临床上的应用。PLGA的性质、微球的制备方法、微球的制备参数都在不同程度上影响微球的突释，并且可能是多因素协同作用。通过对上述各种因素加以适当控制，可在一定程度上减少微球的突释率。通过该方面的机制研究对指导新药开发具有重要意义。

关键词: 聚乳酸-羟基乙酸, 多肽蛋白类药物, 微球, 突释, 控制

Abstract:

BACKGROUND: Burst release is key technology that limits the wide application of protein/peptide microspheres. It should be a problem to be solved.
OBJECTIVE: To make a detailed introduction about burst release reason, influence factors and reduction methods after analyzing recent progress of burst release and control of protein/peptide drug loaded poly(lactic-co-glycolic acid) (PLGA).  
METHODS: Relevant articles in PubMed and CNKI published 1999-01/2010-12 were searched by computer with the key words of “PLGA, peptide, protein, microspheres, burst release, control” in Chinese and English. Articles addressing originally identification, reliability, general analysis, and high correlation were included. Exclusive criteria: repetitive and obsolescent articles. A total of 24 articles were reserved for review.
RESULTS AND CONCLUSION: We need to comprehend mechanism of burst release of protein/peptide microspheres to realize enlargement application. Burst release was influenced by multifactors, such as characters of PLGA, preparation methods and preparation parameters. Burst release could be reduced some degree by the control of the above mentioned. It is very important to research of new drugs.

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